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Invitrogen
PCP4 Monoclonal Antibody (CL5306)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
MA5-35027
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
CL5306
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.70 mg/mL
规格
70 µg
纯化类型
Protein A
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: GAGATNGKDK TSGENDGQKK VQEEFDIDMD APETERAAVA IQSQFRKFQK KK
Highest antigen sequence indentity to the following orthologs: Rat - 96%, Mouse - 96%.
靶标信息
PCP-4 (Purkinje cell protein 4), also known as PCP4, is a calmodulin (CaM) regulatory protein that is highly expressed in neuronal cells. Through its IQ motif, PCP-4 mediates both the calcium-dependent binding properties of CaM and the rates of association and dissociation of calcium from the C-terminal domain of CaM. The IQ motif contains a serine residue which can be phosphorylated by all isoforms of protein kinase C (PKC). PCP-4 is implicated in uterine leiomyomas, as well as in neurodegenerative disorders such as Alzheimer's disease and Huntington's disease. Additionally, overexpression of PCP-4 is thought to play a role in cerebellar hypoplasia, a key feature of Down syndrome.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: brain specific polypeptide PEP19; brain-specific antigen PCP-4; brain-specific polypeptide PEP-19; Neuron specific protein PEP-19 (Purkinje cell protein 4); neuron-specific protein PEP-19; PCP4; unnamed protein product
基因别名: P16Rimb19; Pcp-4; PEP-19; Pep19; PEPZ19
UniProt ID: (Human) P48539, (Mouse) P63054, (Rat) P63055
Entrez Gene ID: (Human) 5121, (Mouse) 18546, (Rat) 25510
negative regulation of protein kinase activity
positive regulation of neuron projection development
positive regulation of dopamine secretion
negative regulation of neuron apoptotic process
positive regulation of neuron differentiation
positive regulation of CAMKK-AMPK signaling cascade
osteoblast differentiation
cellular response to L-glutamate
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
