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Invitrogen
PD-L1/VEGF Biosimilar Recombinant Human Monoclonal Antibody
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产品信息
MA5-60151
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Human
/ IgG1
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
偶联物
形式
Lyophilized
浓度
1 mg/mL
纯化类型
Protein A
保存液
25mM histidine, pH 6.2, with 8% sucrose, 0.01% Tween 80
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Dry ice (international)
RRID
产品详细信息
For reconstitution, add sterile, distilled water to achieve a final antibody concentration of 1 mg/mL. Gently shake to solubilize the protein completely. Do not vortex. Reconstituted products should be stored at -80 °.
This antibody can also be cross referenced by the term Pm8002.
靶标信息
The PD-L1 (Programmed Death-Ligand 1) gene, located on chromosome 9p24.1, is essential for immune response modulation and evasion by cancer cells. It encodes a protein comprising extracellular IgV and IgC domains, a transmembrane domain, and a short cytoplasmic tail. PD-L1 binds to the PD-1 receptor on T cells, inhibiting their activity to allow tumor cells to evade immune detection. PD-L1 expression is regulated at multiple levels: genetic, epigenetic, transcriptional, and post-transcriptional. Similarly, VEGF (Vascular Endothelial Growth Factor) is a critical regulator of angiogenesis and vasculogenesis, located on chromosome 6p21.1. VEGF-A, the most studied isoform, promotes endothelial cell proliferation, migration, and survival, primarily through binding to VEGFR1 and VEGFR2 receptors. VEGF is pivotal in both physiological processes like wound healing and pathological conditions such as cancer, where it facilitates tumor growth by enhancing blood supply.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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