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Invitrogen
PDCD10 Polyclonal Antibody
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PDCD10 Antibody (PA5-90441) in WB
Western blot analysis of PDCD10 in extracts from normal (control) and PDCD10 knockout (KO) HeLa cells. Samples were incubated with PDCD10 Polyclonal antibody (Product # PA5-90441) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 15s.
产品信息
PA5-90441
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 1-212 of human PDCD10 (NP_0091482)
偶联物
形式
Liquid
浓度
0.53 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.01% thimerosal
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: MRMTMEEMKN EAETTSMVSM PLYAVMYPVF NELERVNLSA AQTLRAAFIK AEKENPGLTQ DIIMKILEKK SVEVNFTESL LRMAADDVEE YMIERPEPEF QDLNEKARAL KQILSKIPDE INDRVRFLQT IKDIASAIKE LLDTVNNVFK KYQYQNRRAL EHQKKEFVKY SKSFSDTLKT YFKDGKAINV FVSANRLIHQ TNLILQTFKT VA; Positive Samples: A-431, HepG2, Jurkat, MCF7, Mouse thymus, Mouse brain; Cellular Location: Cell membrane, Cytoplasm, Cytoplasmic side, Golgi apparatus membrane, Peripheral membrane protein
靶标信息
This gene encodes an evolutionarily conserved protein associated with cell apoptosis. The protein interacts with the serine/threonine protein kinase MST4 to modulate the extracellular signal-regulated kinase (ERK) pathway. It also interacts with and is phosphoryated by serine/threonine kinase 25, and is thought to function in a signaling pathway essential for vascular developent. Mutations in this gene are one cause of cerebral cavernous malformations, which are vascular malformations that cause seizures and cerebral hemorrhages. Multiple alternatively spliced variants, encoding the same protein, have been identified.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: apoptosis-related protein 15; Cerebral cavernous malformations 3 protein; MGC1212; MGC24477; PDCD 10; Programmed cell death protein 10; TF-1 cell apoptosis-related protein 15
基因别名: 2410003B13Rik; CCM3; PDCD10; Tfa15; TFAR15
UniProt ID: (Human) Q9BUL8, (Rat) Q6NX65, (Mouse) Q8VE70
Entrez Gene ID: (Human) 11235, (Rat) 494345, (Mouse) 56426
angiogenesis
apoptotic process
positive regulation of cell proliferation
positive regulation of gene expression
negative regulation of gene expression
positive regulation of cell migration
positive regulation of stress-activated MAPK cascade
positive regulation of peptidyl-serine phosphorylation
regulation of Rho protein signal transduction
intrinsic apoptotic signaling pathway in response to hydrogen peroxide
response to hydrogen peroxide
negative regulation of apoptotic process
stress fiber assembly
positive regulation of MAP kinase activity
wound healing, spreading of cells
positive regulation of Notch signaling pathway
protein stabilization
establishment of Golgi localization
positive regulation of protein serine/threonine kinase activity
negative regulation of cell migration involved in sprouting angiogenesis
Golgi reassembly
negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
