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Proteintech
PDE1A Polyclonal Antibody
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产品信息
12442-2-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
PDE1A Fusion Protein Ag3157 (185-545 aa encoded by BC022480)
偶联物
形式
Liquid
浓度
0.29 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: TRYDLINRF KIPVSCLITF AEALEVGYSK YKNPYHNLIH AADVTQTVHY IMLHTGIMHW LTELEILAMV FAAAIHDYEH TGTTNNFHIQ TRSDVAILYN DRSVLENHHV SAAYRLMQEE EMNILINLSK DDWRDLRNLV IEMVLSTDMS GHFQQIKNIR NSLQQPEGID RAKTMSLILH AADISHPAKS WKLHYRWTMA LMEEFFLQGD KEAELGLPFS PLCDRKSTMV AQSQIGFIDF IVEPTFSLLT DSTEKIVIPL IEEASKAETS SYVASSSTTI VGLHIADALR RSNTKGSMSD GSYSPDYSLA AVDLKSFKNN LVDIIQQNKE RWKELAAQGE SDLHKNSEDL VNAEEKHDET HS (185-545 aa encoded by BC022480)
靶标信息
Cyclic nucleotide phosphodiesterases (PDEs) play a role in signal transduction by regulating intracellular cyclic nucleotide concentrations through hydrolysis of cAMP and/or cGMP to their respective nucleoside 5-prime monophosphates. Members of the PDE1 family, such as PDE1A, are Ca(2+)/calmodulin (see CALM1)that are activated by calmodulin in the presence of Ca(2+) (Michibata et al., 2001).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: 3'-RACE clone 8 phosphodiesterase 1A; 3-RACE clone 8 phosphodiesterase 1A; 61 kDa Cam-PDE; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A; calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase; Cam-PDE 1A; Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A; hCam-1; HS MGC26303; MGC26303; phosphodiesterase 1A, calmodulin-dependent; phosphodiesterase-1A
基因别名: 3'-RACEclone8phosphodiesterase1A; 3-RACEclone8phosphodiesterase1A; AI987702; AW125737; CAM-PDE-1A; HCAM-1; HCAM1; HSPDE1A; PDE1A
UniProt ID: (Human) P54750, (Mouse) Q61481
Entrez Gene ID: (Human) 5136, (Mouse) 18573, (Rat) 81529
3',5'-cyclic-AMP phosphodiesterase activity
calmodulin-dependent cyclic-nucleotide phosphodiesterase activity
calmodulin binding
metal ion binding
3',5'-cyclic-GMP phosphodiesterase activity
3',5'-cyclic-nucleotide phosphodiesterase activity
phosphoric diester hydrolase activity
hydrolase activity
cGMP binding
calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity
phosphodiesterase
