Proteintech

PDE4D Polyclonal Antibody

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说明书
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说明书
实验方案
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说明书
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问题与答案
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PDE4D Polyclonal Antibody

产品信息

12918-1-AP

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:500-1:3,000
查看18篇已发表文章 18篇已发表文章

免疫组化 (IHC)

-
查看3篇已发表文章 3篇已发表文章

免疫组化（石蜡） (IHC (P))

1:50-1:500
-

免疫细胞化学 (ICC/IF)

1:100
查看2篇已发表文章 2篇已发表文章
产品规格

种属反应

Human, Mouse, Rat

已发表种属

Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

PDE4D Fusion Protein Ag3588 (170-518 aa encoded by BC036319)
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.14 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice (domestic); Dry ice (international)

产品详细信息

Immunogen sequence: YHNNIHAAD VVQSTHVLLS TPALEAVFTD LEILAAIFAS AIHDVDHPGV FNQFLINTNS ELALMYNDSS VLENHHLAVG FKLLQEENCD IFQNLTKKQR QSLRKMVIDI VLATDMSKHM NLLADLKTMV ETKKVTSSGV LLLDNYSDRI QVLQNMVHCA DLSNPTKPLQ LYRQWTDRIM EEFFRQGDRE RERGMEISPM CDKHNASVEK SQVGFIDYIV HPLWETWADL VHPDAQDILD TLEDNREWYQ STIPQSPSPA PDDPEEGRQG QTEKFQFELT LEEDGESDTE KDSGSQVEED TSCSDSKTLC TQDSESTEIP LDEQVEEEAV GEEEESQPEA CVIDDRSPDT (170-518 aa encoded by BC036319)

靶标信息

This gene encodes one of four mammalian counterparts to the fruit fly 'dunce' gene. The encoded protein has 3',5'-cyclic-AMP phosphodiesterase activity and degrades cAMP, which acts as a signal transduction molecule in multiple cell types. This gene uses different promoters to generate multiple alternatively spliced transcript variants that encode functional proteins.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

生物信息学

蛋白别名: 3',5'-cyclic-AMP phosphodiesterase 4D; cAMP-specific 3',5'-cyclic phosphodiesterase 4D; cAMP-specific phosphodiesterase 4D; cAMP-specific phosphodiesterase PDE4D; cAMP-specific phosphodiesterase PDE4D6; cAMP-specific phosphodiesterase splice variant PDE4D8; cyclic AMP specific phosphodiesterase PDE4D5A; DKFZp686M11213; DPDE3; dunce; FLJ97311; HGNC:8783; HS PDE4DN2; PDE43; PDE4D3; PDE4D7; Phosphodiesterase 4D cAMP-specific (dunce; phosphodiesterase 4D, cAMP specific; Phosphodiesterase 4D, cAMP-specific (dunce; phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila); testicular tissue protein Li 136

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基因别名: 9630011N22Rik; ACRDYS2; DPDE3; HSPDE4D; PDE43; PDE4D; PDE4DN2; STRK1

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UniProt ID: (Human) Q08499, (Rat) P14270, (Mouse) Q01063

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Entrez Gene ID: (Human) 5144, (Rat) 24627, (Mouse) 238871

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功能
3',5'-cyclic-nucleotide phosphodiesterase activity 3',5'-cyclic-AMP phosphodiesterase activity protein binding drug binding enzyme binding cAMP binding beta-2 adrenergic receptor binding ion channel binding metal ion binding ATPase binding scaffold protein binding cyclic-nucleotide phosphodiesterase activity SH3 domain binding protein domain specific binding ubiquitin protein ligase binding phosphoric diester hydrolase activity hydrolase activity phosphodiesterase
参与通路
regulation of heart rate cAMP catabolic process smooth muscle contraction aging regulation of receptor activity regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum cAMP-mediated signaling neutrophil chemotaxis regulation of cAMP metabolic process positive regulation of interferon-gamma production positive regulation of interleukin-2 production positive regulation of interleukin-5 production negative regulation of peptidyl-serine phosphorylation multicellular organism growth negative regulation of heart contraction T cell receptor signaling pathway regulation of ryanodine-sensitive calcium-release channel activity establishment of endothelial barrier cellular response to lipopolysaccharide cellular response to epinephrine stimulus adrenergic receptor signaling pathway regulation of cardiac muscle cell contraction adrenergic receptor signaling pathway involved in positive regulation of heart rate regulation of cell communication by electrical coupling involved in cardiac conduction negative regulation of relaxation of cardiac muscle memory regulation of G-protein coupled receptor protein signaling pathway regulation of protein kinase A signaling positive regulation of smooth muscle cell migration lung development cellular protein complex assembly positive regulation of smooth muscle cell proliferation leukocyte migration cellular response to cAMP signal transduction
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