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Invitrogen
PDE6A Polyclonal Antibody
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产品信息
PA1-721
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to residues M(16) P Q F A K E Y F D R K L R(29) C of human PDE6 alpha'.
偶联物
形式
Liquid
浓度
Conc. Not Determined
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
PA1-721 detects phosphodiesterase 6 alpha' (PDE6 alpha') from sheep, human and bovine retinal extract.
PA1-721 has been successfully used in Western blot procedures. By Western blot, this antibody detects an ~90 kDa protein representing PDE6 alpha' from sheep and bovine retinal extract.
The PA1-721 immunogen is a synthetic peptide corresponding to residues M(16) P Q F A K E Y F D R K L R(29) C of human PDE6 alpha'. This sequence is completely conserved between human, chicken and frog. PA1-721 immunizing peptide (Cat. # PEP-149) is available for use in neutralization and control experiments.
靶标信息
This gene encodes the cyclic-GMP (cGMP)-specific phosphodiesterase 6A alpha subunit, expressed in cells of the retinal rod outer segment. The phosphodiesterase 6 holoenzyme is a heterotrimer composed of an alpha, beta, and two gamma subunits. cGMP is an important regulator of rod cell membrane current, and its dynamic concentration is established by phosphodiesterase 6A cGMP hydrolysis and guanylate cyclase cGMP synthesis. The protein is a subunit of a key phototransduction enzyme and participates in processes of transmission and amplification of the visual signal. Mutations in this gene have been identified as one cause of autosomal recessive retinitis pigmentosa.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
