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Proteintech
PDGF-D Polyclonal Antibody, CoraLite® Plus 488
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产品信息
CL488-14075
产品规格
种属反应
Human,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
PDGF-D fusion protein Ag5154
偶联物
激发/发射光谱
493/522 nm
形式
Liquid
浓度
1000 µg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol, 0.5% BSA
内含物
0.05% ProClin 300
保存条件
-20°C, store in dark
运输条件
Wet ice
产品详细信息
Sequence of this protein is as follows: MHRLIFVYTL ICANFCSCRD TSATPQSASI KALRNANLRR DDLYRRDETI QVKGNGYVQS PRFPNSYPRN LLLTWRLHSQ ENTRIQLVFD NQFGLEEAEN DICRYDFVEV EDISETSTII RGRWCGHKEV PPRIKSRTNQ IKITFKSDDY FVAKPGFKIY YSLLEDFQPA AASETNWESV TSSISGVSYN SPSVTDPTLI ADALDKKIAE FDTVEDLLKY FNPESWQEDL ENMYLDTPRY RGRSYHDRKS KVDLDRLNDD AKRYSCTPRN YSVNIREELK LANVVFFPRC LLVQRCGGNC GCGTVNWRSC TCNSGKTVKK YHEVLQFEPG HIKRRGRAKT MALVDIQLDH HERCDCICSS RPPR
靶标信息
The platelet-derived growth factor (PDGF) family consists of four members; PDGF-A, PDGF-B, PDGF-C and PDGF-D (spinal cord-derived growth factor-B or iris-expressed growth factor). PDGF members form disulphide-bonded dimeric isoforms, which are important for growth, survival and function in several types of connective tissue cells. Their biological effects are mediated via two tyrosine kinase receptors, PDGFR-a and PDGFR-b, and PDGF-mediated signaling is critical for development of many organ systems. PDGF-D has a two-domain structure similar to PDGF-C and is secreted as a disulphide-linked homodimer, PDGF-DD. PDGF-D induces cellular transformation and promotes tumor growth by accelerating the proliferation rate of tumor cells and by stimulation of tumor neovascularization. PDGF-D may play a role in the development of brain tumors. The potential oncogenic activity of PDGF-DD may be important for the development and/or progression of prostate cancer. PDGF-D is expressed in fibroblastic adventitial cells, cultured endothelial cells and in a variety of tumor cell lines including those derived from ovarian, renal and lung cancers, as well as from astrocytomas and medulloblastomas. PDGF-D is expressed in the human kidney.
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生物信息学
蛋白别名: Iris-expressed growth factor; PDGF-D; Platelet-derived growth factor D; platelet-derived growth factor, D polypeptide; SCDGF-B; spinal cord derived growth factor B; Spinal cord-derived growth factor B; spinal cord-derived growth factor-B; spinal-cord derived growth factor-B protein
基因别名: IEGF; MSTP036; PDGFD; rSCDGF-B; SCDGF-B; SCDGFB; UNQ1899/PRO4345
UniProt ID: (Human) Q9GZP0, (Rat) Q9EQT1
Entrez Gene ID: (Human) 80310, (Rat) 66018
multicellular organism development
blood coagulation
positive regulation of cell proliferation
positive regulation of phosphatidylinositol 3-kinase signaling
positive regulation of cell migration
positive regulation of protein autophosphorylation
cellular response to platelet-derived growth factor stimulus
positive regulation of MAP kinase activity
platelet-derived growth factor receptor signaling pathway
positive regulation of fibroblast proliferation
positive regulation of smooth muscle cell proliferation
regulation of peptidyl-tyrosine phosphorylation
positive regulation of cell division
cellular response to hydrogen peroxide
positive regulation of ERK1 and ERK2 cascade
cellular response to amino acid stimulus
cellular response to transforming growth factor beta stimulus
positive regulation of smooth muscle cell chemotaxis
positive regulation of glomerular mesangial cell proliferation
positive regulation of monocyte extravasation
