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Agrisera
PDR8/ABC transporter G family member 36 Polyclonal Antibody
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PDR8/ABC transporter G family member 36 Antibody (AS22-4846) in WB
Total protein (T) or microsomal protein fraction (M/P 100) were extracted from 8-day-old Arabidopsis thaliana seedlings according to (1). Seedling genotypes include Col-0 (wild-type) and PEN 3-GFP/pen 3-1, withpen 3-1 being a knock-down mutant (2). Note that PEN 3 is also referred to as PDR 8 or ABCG 36; and the expected apparent MW of PDR 8/PEN 3/ABCG 36 is 165 k D and that of PDR 8/PEN 3-GFP is 192 k D. 3... View More
产品信息
AS22-4846
产品规格
种属反应
Plant
宿主/亚型
Rabbit
分类
Polyclonal
类型
Antibody
抗原
KLH-conjugated synthetic peptide derived from Arabidopsis thaliana PDR8.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Lyophilized
保存液
whole serum
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Store lyophilized/reconstituted at -20°C; once reconstituted make aliquots to avoid repeated freeze-thaw cycles. Please remember to spin the tubes briefly prior to opening them to avoid any losses that might occur from material adhering to the cap or sides of the tube.
For reconstitution add 50 µL of sterile water.
Specific Species Reactivity: Arabidopsis thaliana
靶标信息
PDR8 encodes a eukaryotic transcriptional regulator that localizes to the nucleus and functions as a zinc-cluster (Zn2Cys6) DNA-binding protein typical of fungal C6 transcription factors, with an N-terminal binuclear zinc-cluster DNA-binding domain and a larger C-terminal regulatory region that supports promoter binding and transcriptional activation. In Saccharomyces cerevisiae, Pdr8 modulates pleiotropic drug resistance by regulating expression of multiple detoxification and stress-response genes, including transporters from the ATP-binding cassette and major facilitator superfamily, thereby influencing cellular tolerance to xenobiotics and contributing to broader physiological traits such as growth on nonfermentable carbon sources and aspects of cell wall integrity; altered PDR8 dosage correspondingly changes resistance to specific compounds (e.g., increased resistance upon overexpression). In plants, PDR8 refers to an ATP-binding cassette transporter of the ABCG/PDR class that localizes to the plasma membrane and acts as an ATP-dependent efflux pump affecting the export of small molecules, with demonstrated roles in cadmium tolerance via extrusion of Cd species and in innate immunity by modulating the extent of pathogen-induced cell death, consistent with a broad substrate profile for defense- and stress-associated metabolites.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ABCG36; PEN3; PLEIOTROPIC DRUG RESISTANCE8
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