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Invitrogen
PHD4 Polyclonal Antibody
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产品信息
PA1-32331
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to a portion of the C-terminus
of the human prolyl hydroxylase domain-containing 4
encoded within exon 4. [LocusLink 54681]
of the human prolyl hydroxylase domain-containing 4
encoded within exon 4. [LocusLink 54681]
偶联物
形式
Liquid
浓度
1 mg/mL
保存条件
4°C, do not freeze
运输条件
Wet ice
产品详细信息
PA1-32331 detects PHD4 from human samples.
PA1-32331 has been successfully used in Western blot applications.
The PA1-32331 immunogen is: Synthetic peptide corresponding to a portion of the C-terminus of the human prolyl hydroxylase domain-containing 4 encoded within exon 4. [LocusLink 54681].
靶标信息
Prolyl hydroxylase 4 is a prolyl hydroxylase that modifies HIF-alpha. Classic prolyl hydroxylases are found in the endoplasmic reticulum and modify collagen, whereas HIF is an intracellular protein and the prolyl hydroxylase sites do not resemble those modifying collagen. HIF is a transcriptional complex that plays a critical role in oxygen homeostasis. Prolyl hydroxylase is an essential component of the pathway through which cells sense oxygen. In the presence of oxygen, prolyl hydroxylases convert specific prolyl residues in HIF-alpha to hydroxyproline, leading to HIF-alpha destruction. Low oxygen levels, sensed at the cellular level, cause the HIF conversion to be reduced so that HIF is stable and there is increased angiogenesis. Prolyl hydroxylase 4, specifically, catalyzes the posttranslational formation of 4-hydroxyproline in HIF alpha proteins. It may function as a cellular oxygen sensor and, under normoxic conditions, may targets HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitylation complex.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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