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Proteintech
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Immunogen sequence: MEEKRRKYS ISSDNSDTTD SHATSTSASR CSKLPSSTKS GWPRQNEKKP SEVFRTDLIT AMKIPDSYQL SPDDYYILAD PWRQEWEKGV QVPAGAEAIP EPVVRILPPL EGPPAQASPS STMLGEGSQP DWPGGSRYDL DEIDAYWLEL INSELKEMER PELDELTLER VLEELETLCH QNMARAIETQ EGLGIEYDED VVCDVCRSPE GEDGNEMVFC DKCNVCVHQA CYGILKVPTG SWLCRTCALG VQPKCLLCPK RGGALKPTRS GTKWVHVSCA LWIPEVSIGC PEKMEPITKI S (1-300 aa encoded by BC021962)
Scaffold subunit of some HBO1 complexes, which have a histone H4 acetyltransferase activity (PubMed:16387653). Acts as a E3 ubiquitin-protein ligase mediating the ubiquitination and subsequent proteasomal degradation of target protein histone demethylase KDM1A (PubMed:25018020). Also acts as a ubiquitin ligase E3 toward itself. Positive regulator of neurogenesis. [UniProt]
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: E3 ubiquitin-protein ligase Jade-2; Jade family PHD finger protein 2; PHD finger protein 15
基因别名: JADE-2; JADE2; KIAA0239; PHF15
UniProt ID: (Human) Q9NQC1
Entrez Gene ID: (Dog) 481508, (Human) 23338