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Invitrogen
PHLPP1 Polyclonal Antibody
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产品信息
PA5-75679
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to residues in Human PHLPP1.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 50% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
靶标信息
PHLPP1 is a member of the serine/threonine phosphatase family, which are important regulators of Akt serine-threonine kinases (AKT1, AKT2, AKT3) and conventional/novel protein kinase C (PKC) isoforms. PHLPP1 and PHLPP2 have a similar domain structure and have been shown to dephosphorylate and inactivate, distinct Akt isoforms, at one of the two critical phosphorylation sites required for activation: Serine473. PHLPP2 dephosphorylates AKT1 and AKT3, whereas PHLPP1 is specific for AKT2 and AKT3. PHLPP1 promotes apoptosis and may act as a tumor suppressor. Increased expression of PHLPP1 may also play a role in obesity and type 2 diabetes by interfering with Akt-mediated insulin signaling.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Circadian Oscillatory Protein (SCOP); EC 3.1.3.16; hSCOP; PH domain leucine-rich repeat protein phosphatase 1; PH domain leucine-rich repeat-containing protein phosphatase 1; PH domain-containing family E member 1; pleckstrin homology domain containing, family E (with leucine rich repeats) member 1; Pleckstrin homology domain-containing family E member 1; pleckstrin homology domain-containing family E protein 1; protein phosphatase, Mg2+/Mn2+ dependent 3A; SCN circadian oscillatory protein; Suprachiasmatic nucleus circadian oscillatory protein
基因别名: AI836256; KIAA0606; mKIAA0606; PHLPP; PHLPP1; PLEKHE1; PPM3A; SCOP
UniProt ID: (Human) O60346, (Mouse) Q8CHE4, (Rat) Q9WTR8
Entrez Gene ID: (Human) 23239, (Mouse) 98432, (Rat) 59265
regulation of T cell anergy
protein dephosphorylation
apoptotic process
entrainment of circadian clock
regulation of apoptotic process
regulation of MAPK cascade
regulation of JNK cascade
negative regulation of protein kinase B signaling
regulation of p38MAPK cascade
regulation of protein phosphorylation
negative regulation of protein kinase C signaling
circadian rhythm
metabolic process
hippocampus development
