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Invitrogen
PHOX2A Polyclonal Antibody
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产品信息
PA1-28070
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
synthetic peptide FPEPSGLHEKRKQRRIR conjugated to BSA, corresponding to amino acids 78-94 of Human PHOX2A.
偶联物
形式
Liquid
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
产品详细信息
PA1-28070 detects PHOX2A from rat, mouse, human samples.
PA1-28070 has been successfully used in immunohistochemistry, immunoprecipitation, Western blot applications.
The PA1-28070 immunogen is a synthetic peptide: FPEPSGLHEKRKQRRIR conjugated to BSA, corresponding to amino acids 78-94 of Human PHOX2A.
靶标信息
PHOX2A and PHOX2B (Paired mesoderm homeobox protein) are closely related, paired-homeodomain transcription factors that function as determinants of the noradrenergic phenotype during embryogenesis. PHOX2 proteins are crucial for the regulation of endogenous hydroxylases in neural crest cells and promote sympathetic neuron generation. Human PHOX2B contains one DNA binding homeobox domain and is required for the differentiation of all central and nonperipheral noradrenergic centers in the brain. In contrast, PHOX2A controls only the differentiation of the main noradrenergic center of the brain. Regulation of PHOX2 may have therapeutic utility in aging or disorders involving degeneration of noradrenergic neurons.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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