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Invitrogen

PI3 Kinase p85 alpha/beta Recombinant Rabbit Monoclonal Antibody (5P8A8)

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说明书
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产品信息

MA575443

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:500-1:2,000
-

免疫组化（石蜡） (IHC (P))

1:200-1:800
-

酶联免疫吸附实验 (ELISA)

1 µg/mL
-
产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

Expression System

HEK293 cells

分类

Recombinant Monoclonal

类型

Antibody

克隆号

5P8A8

抗原

Synthetic peptide. This information is considered to be commercially sensitive.

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1.5 mg/mL

规格

150 µg

纯化类型

Affinity chromatography

保存液

PBS, pH 7.4, with 0.05% BSA, 50% glycerol

内含物

0.05% ProClin 300

保存条件

-20°C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

靶标信息

The p85 alpha and p85 beta proteins are regulatory subunits of class IA phosphoinositide 3-kinases (PI3Ks), which control cell growth, survival, metabolism, and migration. They stabilize and inhibit the catalytic p110 subunits under basal conditions and help recruit PI3K to activated receptor signaling complexes, making them key regulators of the PI3K/AKT pathway frequently altered in cancer.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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Cite this product

生物信息学

蛋白别名: growth factor receptor bound 1; p85-alpha; GRB1; phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha; phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta; phosphatidylinositol 3-kinase p85 alpha; phosphatidylinositol 3-kinase, regulartory subunit, polypeptide 2; phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha); phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 2 (p85 beta); phosphatidylinositol 3-kinase-associated p-85 alpha; Phosphoinositide 3-kinase p85 (other splicing variants: p55 and p50); Phosphoinositide 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha); phosphoinositide-3-kinase regulatory subunit alpha; phosphoinositide-3-kinase regulatory subunit beta; phosphoinositide-3-kinase, regulatory subunit 1 (alpha); phosphoinositide-3-kinase, regulatory subunit 2 (beta); PI3 kinase-associated p85; PI3-kinase p85 subunit alpha; PI3-kinase p85 subunit beta; PI3-kinase regulatory subunit alpha; PI3-kinase regulatory subunit beta; PI3-kinase subunit p85-alpha; PI3-kinase subunit p85-beta; PI3K regulatory subunit alpha; PI3K regulatory subunit beta; PI3K-p46; ptdIns-3-kinase p85-alpha; ptdIns-3-kinase p85-beta; ptdIns-3-kinase regulatory subunit alpha; ptdIns-3-kinase regulatory subunit beta; ptdIns-3-kinase regulatory subunit p85-alpha; ptdIns-3-kinase regulatory subunit p85-beta; unnamed protein product

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基因别名: AGM7; GRB1; IMD36; MPPH; MPPH1; p50alpha; p55alpha; p85; p85-ALPHA; p85-BETA; p85alpha; P85B; p85beta; PI3K; PI3KA

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UniProt ID: (Human) P27986, (Human) O00459, (Mouse) P26450, (Rat) Q63787, (Mouse) O08908

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Entrez Gene ID: (Human) 5295, (Human) 5296, (Mouse) 18708, (Rat) 25513, (Mouse) 18709, (Rat) 29741

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功能
phosphotyrosine binding transmembrane receptor protein tyrosine kinase adaptor activity insulin receptor binding insulin-like growth factor receptor binding neurotrophin TRKA receptor binding protein binding kinase regulator activity kinase activator activity protein phosphatase binding phosphatidylinositol 3-kinase regulator activity phosphatidylinositol 3-kinase regulatory subunit binding ErbB-3 class receptor binding phosphatidylinositol 3-kinase binding insulin binding insulin receptor substrate binding 1-phosphatidylinositol-3-kinase regulator activity protein heterodimerization activity phosphatidylinositol kinase activity enzyme-substrate adaptor activity phosphatidylinositol 3-kinase activator activity receptor tyrosine kinase binding receptor binding platelet-derived growth factor receptor binding calmodulin binding 1-phosphatidylinositol-3-kinase activity protein kinase binding protein domain specific binding estrogen receptor binding ubiquitin protein ligase binding ATPase binding phosphoprotein binding
参与通路
cellular glucose homeostasis positive regulation of protein phosphorylation negative regulation of cell-matrix adhesion glucose metabolic process protein phosphorylation protein import into nucleus negative regulation of cell adhesion signal transduction insulin receptor signaling pathway extrinsic apoptotic signaling pathway via death domain receptors intrinsic apoptotic signaling pathway in response to DNA damage negative regulation of heart rate positive regulation of lamellipodium assembly positive regulation of gene expression negative regulation of muscle cell apoptotic process cytokine-mediated signaling pathway negative regulation of cell-cell adhesion B cell differentiation positive regulation of cell migration positive regulation of tumor necrosis factor production response to insulin cellular response to insulin stimulus positive regulation of RNA splicing regulation of toll-like receptor 4 signaling pathway cellular response to UV response to endoplasmic reticulum stress interleukin-18-mediated signaling pathway phosphatidylinositol-3-phosphate biosynthetic process natural killer cell mediated cytotoxicity positive regulation of protein import into nucleus negative regulation of apoptotic process protein kinase B signaling positive regulation of cellular component biogenesis positive regulation of myoblast differentiation negative regulation of osteoclast differentiation negative regulation of blood pressure negative regulation of proteolysis positive regulation of transcription from RNA polymerase II promoter phosphatidylinositol metabolic process phosphatidylinositol phosphorylation insulin-like growth factor receptor signaling pathway positive regulation of smooth muscle cell proliferation negative regulation of smooth muscle cell proliferation protein stabilization positive regulation of cellular component organization negative regulation of multicellular organismal process response to glucocorticoid positive regulation of filopodium assembly regulation of stress fiber assembly negative regulation of stress fiber assembly response to cAMP positive regulation of synapse assembly growth hormone receptor signaling pathway T follicular helper cell differentiation positive regulation of focal adhesion disassembly positive regulation of endoplasmic reticulum unfolded protein response regulation of protein localization to plasma membrane protein polyubiquitination immune response T cell differentiation substrate adhesion-dependent cell spreading positive regulation of glucose import positive regulation of protein localization to plasma membrane regulation of autophagy negative regulation of MAPK cascade regulation of actin filament polymerization positive regulation of cell adhesion negative regulation of cell migration involved in sprouting angiogenesis response to yeast response to nutrient response to xenobiotic stimulus response to fructose response to iron(II) ion response to estradiol response to progesterone response to testosterone response to amino acid response to ethanol response to fatty acid response to growth factor cellular response to fatty acid response to dexamethasone regulation of locomotion
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