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Proteintech
PI4K2A Polyclonal Antibody
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产品信息
15318-1-AP
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
PI4K2A Fusion Protein Ag7564 (131-479 aa encoded by BC003167)
偶联物
形式
Liquid
浓度
0.13 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: YQGSSGSYF VKDPQGRIIA VFKPKNEEPY GHLNPKWTKW LQKLCCPCCF GRDCLVLNQG YLSEAGASLV DQKLELNIVP RTKVVYLASE TFNYSAIDRV KSRGKRLALE KVPKVGQRFN RIGLPPKVGS FQLFVEGYKD ADYWLRRFEA EPLPENTNRQ LLLQFERLVV LDYIIRNTDR GNDNWLIKYD CPMDSSSSRD TDWVVVKEPV IKVAAIDNGL AFPLKHPDSW RAYPFYWAWL PQAKVPFSQE IKDLILPKIS DPNFVKDLEE DLYELFKKDP GFDRGQFHKQ IAVMRGQILN LTQALKDNKS PLHLVQMPPV IVETARSHQR SSSESYTQSF QSRKPFFSWW (131-479 aa encoded by BC003167)
靶标信息
PI4K2A (PI4K2 alpha) lipid kinase or phosphatidylinositol 4-kinase type 2 alpha is involved in the formation of phosphatidylinositolpolyphosphates (PtdInsPs) which are centrally involved in many biologic processes ranging from cell growth and organization of the actin cytoskeleton to endo- and exocytosis. PI4K2A phosphorylates PtdIns at the D-4 position which is an essential step in the biosynthesis of PtdInsPs. PI4K2A is a novel regulator of tumor growth by its action on angiogenesis and HIF-1alpha regulation. PI4K2A generates PtdIns4P-rich domains within the Golgi which regulate targeting of clathrin adaptor AP-1 complexes. PI4K2A is also required for Wnt to regulate LRP6 phosphorylation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: 55 kDa type II phosphatidylinositol 4-kinase; null; phosphatidylinositol 4-kinase; Phosphatidylinositol 4-kinase type 2-alpha; phosphatidylinositol 4-kinase type II; phosphatidylinositol 4-kinase type II (PI4KII); Phosphatidylinositol 4-kinase type II-alpha
基因别名: Pi4k2; PI4K2A; PI4KII; PIK42A
UniProt ID: (Human) Q9BTU6, (Mouse) Q2TBE6, (Rat) Q99M64
Entrez Gene ID: (Human) 55361, (Mouse) 84095, (Rat) 114554
