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Immunogen sequence: GPNLKAWLRV FSRNGVTSIW EN
Highest antigen sequence identity to the following orthologs: Mouse - 100%, Rat - 95%.
Phosphatidylinositol-glycans(PIGs) aremulti-passtransmembrane proteins that localize to the endoplasmicreticulum. PIGs exhibitvariousfunctions but all are crucial for the biosynthesis of the glycosylphosphatidylinositol (GPI) anchor. Some PIG proteins are components of the GPI transamidase complex and play a role in the recognition of either the GPI attachmentsignal or the lipid portion of GPI. Other PIGs belong to the glycosyltransferase complex and function in the transfer of N-acetylglucosamine (GlcNAc) to phosphatidyli nositol (PI). A variety of other PIGs play distinct rolesin GPIsynthesis. PIG-F functions as an auxiliary subunit of ethanolamine phosphate (EtNP) transferases. It associates with PIG-O and isrequired for its expression and stability. Together these two PIGs function as an EtNP transferase and catalyze the transfer of EtNP to the third mannose (Man-3) of GPI. Amutation in the gene encoding PIG-F may result in a block of EtNP addition to Man-3 and lead to an absence of GPI-anchored proteins.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: GPI11 homolog; phosphatidylinositol glycan anchor biosynthesis, class F; Phosphatidylinositol-glycan biosynthesis class F protein; PIG-F
基因别名: PIGF
UniProt ID: (Human) Q07326
Entrez Gene ID: (Human) 5281
分子生物学功能: glycosyltransferase