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Immunogen sequence: IALGITVLYQ LALDFTSLKR LILYGTDGSG TRVGLLNANR EGIISTLGYV
For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Predicted homology: Cow: 100%; Dog: 93%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 93%; Rat: 93%
Phosphatidylinositol-glycans (PIGs) are multi-pass transmembrane proteins that localize to the endoplasmic reticulum. PIGs exhibit various functions, but all are crucial for the biosynthesis of the glycosylphosphatidylinositol (GPI)-anchor. Some PIG proteins are components of the GPI transamidase complex and play a role in the recognition of either the GPI attachment signal or the lipid portion of GPI. Other PIGs belong to the glycosyltransferase complex and function in the transfer of N-acetylglucosamine (GlcNAc) to phosphatidylinositol (PI). A variety of other PIGs play distinct roles in GPI synthesis including mannosylation of the GPI-anchor. PIG-W (Phosphatidylinositol-glycan biosynthesis class W protein) is a 504 amino acid multi-pass membrane protein that functions in the third step of GPI biosynthesis and acylates the inositol ring of phosphatidylinositol.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: phosphatidylinositol glycan anchor biosynthesis, class W; phosphatidylinositol glycan, class W; Phosphatidylinositol-glycan biosynthesis class W protein; PIG-W
基因别名: Gwt1; HPMRS5; PIGW
UniProt ID: (Human) Q7Z7B1
Entrez Gene ID: (Human) 284098
分子生物学功能: acyltransferase transferase metabolite interconversion enzyme