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Invitrogen
PILRA Polyclonal Antibody
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PILRA Antibody (PA5-116743) in WB
Western blot analysis of PILRA in extracts of various cell lines. Samples were incubated with PILRA Polyclonal antibody (Product # PA5-116743) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.
产品信息
PA5-116743
产品规格
种属反应
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 20-180 of human PILRA (NP_8400561)
偶联物
形式
Liquid
浓度
0.74 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.01% thimerosal
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Positive Samples: Mouse liver, Rat liver
Immunogen sequence: QPSGSTGSGP SYLYGVTQPK HLSASMGGSV EIPFSFYYPW ELATAPDVRI SWRRGHFHRQ SFYSTRPPSI HKDYVNRLFL NWTEGQKSGF LRISNLQKQD QSVYFCRVEL DTRSSGRQQW QSIEGTKLSI TQGQQRTKAT TPAREPFQNT EEPYENIRNE G
靶标信息
SHP-1-mediated dephosphorylation of protein tyrosine residues is central to the regulation of several cell signaling pathways. Two types of inhibitory receptor superfamily members are immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing receptors and their non-ITIM-bearing, activating counterparts. Control of cell signaling via SHP-1 is thought to occur through a balance between PILRalpha-mediated inhibition and PILR beta-mediated activation. This particular gene encodes the ITIM-bearing member of the receptor pair, which functions in the inhibitory role.Cell signaling pathways rely on a dynamic interaction between activating and inhibiting processes. SHP-1-mediated dephosphorylation of protein tyrosine residues is central to the regulation of several cell signaling pathways. Two types of inhibitory receptor superfamily members are immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing receptors and their non-ITIM-bearing, activating counterparts. Control of cell signaling via SHP-1 is thought to occur through a balance between PILR alpha-mediated inhibition and PILRbeta-mediated activation. These paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This particular gene encodes the ITIM-bearing member of the receptor pair, which functions in the inhibitory role.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Cell surface receptor FDF03; Inhibitory receptor PILR-alpha; Paired immunoglobulin-like type 2 receptor alpha
基因别名: AV021745; FDF03; Pilra
UniProt ID: (Mouse) Q2YFS3
Entrez Gene ID: (Mouse) 231805
