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Abnova
PIP5K1C Polyclonal Antibody, MaxPab™
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
H00023396-B01P
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG
分类
Polyclonal
类型
Antibody
抗原
PIP5K1C (AAH11138.1, 1 a.a. approximately 206 a.a) full-length human protein.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.5-1 mg/mL
规格
50 µg
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MTPRHPLFTS RRPPAQPTRC ARKAPAVEKP DPSPRSPART HTPREQPLHS AQERGRPSSG TGQPRGSQHP SGQAHVGSSL RAQRVCPALG SDLGLSSQPG AHLLAPGIHP SAPALSLRRT PSRHPPGRQG QRSEGVSGTW MASRDRGIVI SKAQPPEATP VLPGSPRVAL PRALAPETPR ACGVTRSSRC GPGRAAPRPG QPPSAE
靶标信息
PIP5K1C lipid kinase or phosphatidylinositol-4-phosphate 5-kinase 1 gamma phosphorylates phosphatidylinositol-4-phosphate to form phosphatidylinositol 4,5-bisphosphate. PIP5K1C is found at synapses and has been found to play roles in endocytosis and cell migration. PIP5K1C directly associates with -beta-catenin and increases -beta-catenin activity downstream of growth factor stimulation. PIP5K1C expression and kinase activity enhance -beta-catenin phosphorylation on residues that promote nuclear importation and transcriptional activity. PIP5K1C deficiency impairs neutrophil recruitment as a result of defect in adhesion. PIP5K1C regulated the adhesion through facilitation of RhoA GTPase and integrin activation by chemo attractants.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: diphosphoinositide kinase; phosphatidylinositol-4-phosphate 5-kinase; phosphatidylinositol-4-phosphate 5-kinase, type I, gamma; phosphoinositide 5-kinase; PIP5K1gamma; PIP5KI gamma; PIP5KI-gamma; PIPKIg_v4; ptdIns(4)P-5-kinase 1 gamma; type I phosphatidylinositol 4-phosphate 5-kinase gamma; type I PIP kinase; unnamed protein product
基因别名: LCCS3; PIP5K-GAMMA; PIP5K1-gamma; PIP5Kgamma
UniProt ID: (Human) O60331
Entrez Gene ID: (Human) 23396
phosphatidylinositol biosynthetic process
phagocytosis
synaptic vesicle exocytosis
actin cytoskeleton organization
neutrophil chemotaxis
adherens junction assembly
phosphatidylinositol metabolic process
phosphatidylinositol phosphorylation
synaptic vesicle endocytosis
regulation of protein kinase B signaling
membrane organization
clathrin-mediated endocytosis
cell-cell adhesion
regulation of postsynaptic neurotransmitter receptor internalization
regulation of synaptic vesicle endocytosis
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Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
