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PITX3 Antibody (710212) in ICC/IF
Immunofluorescent analysis of PITX3 in HeLa cells using a PITX3 Recombinant Rabbit Polyclonal Antibody (Product # 710212) followed by detection using an Alexa Fluor 488-conjugated Goat anti-Rabbit secondary antibody (green) (Image A). Nuclei were stained using DAPI (Image B) and actin stained with Alexa Fluor 594 phalloidin (red) (image C). Image D is a composite image showing localization of PiTX3.
产品信息
710212
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
Expression System
Expi293
分类
Recombinant Superclonal
类型
Antibody
克隆号
7M5HCLC
抗原
Recombinant protein corresponding to amino acids 1-65 of human PiTX3
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2532628
产品详细信息
Recombinant rabbit polyclonal antibodies are unique offerings from Thermo Fisher Scientific. They are comprised of a selection of multiple different recombinant monoclonal antibodies, providing the best of both worlds - the sensitivity of polyclonal antibodies with the specificity of monoclonal antibodies - all delivered with the consistency only found in a recombinant antibody. While functionally the same as a polyclonal antibody - recognizing multiple epitope sites on the target and producing higher detection sensitivity for low abundance targets - a recombinant rabbit polyclonal antibody has a known mixture of light and heavy chains. The exact population can be produced in every lot, circumventing the biological variability typically associated with polyclonal antibody production.
靶标信息
This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. Members of this family act as transcription factors. This protein is involved in lens formation during eye development. Mutations of this gene have been associated with anterior segment mesenchymal dysgenesis and congenital cataracts.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: aphakia; Homeobox protein PITX3; MGC12766; paired-like homeodomain 3; Paired-like homeodomain transcription factor 3; Pituitary homeobox 3; Pituitary homeobox 3 (Homeobox protein PITX3)
基因别名: ak; ASMD; ASOD; CTPP4; CTRCT11; PITX3; PTX3
UniProt ID: (Human) O75364, (Mouse) O35160
Entrez Gene ID: (Human) 5309, (Mouse) 18742
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
sequence-specific DNA binding
homeodomain transcription factor
lens development in camera-type eye
lens morphogenesis in camera-type eye
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
locomotory behavior
organ morphogenesis
midbrain development
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
neuron development
lens fiber cell differentiation
dopaminergic neuron differentiation
transcription, DNA-templated
multicellular organism development
regulation of gene expression
