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PIWIL2 Antibody (PA5-102687) in IHC (P)
Immunohistochemistry analysis of PIWIL2 in mouse testis tissue. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with PIWIL2 polyclonal antibody (Product # PA5-102687) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
产品信息
PA5-102687
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human PIWIL2(Accession Q8TC59), corresponding to amino acid residues C791-E841.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2852082
产品详细信息
Antibody detects endogenous levels of total PIWIL2.
靶标信息
The piwi gene of Drosophila belongs to a novel class of evolutionarily conserved genes (the piwi or Argonaute family). The Piwi family is required for germ and stem cell development in invertebrates, and two Piwi members, MIWI and MILI (Miwi like, Piwil2, Piwi-like protein 2), are essential for spermatogenesis in mouse. MIWI and MILI partner with Piwi-interacting RNAs (piRNAs) which are 26-31 nucleotides in length clearly distinct from the 21-23 nucleotides of microRNAs (miRNAs) or short interfering RNAs (siRNAs). A search for murine small RNAs that might program Piwi proteins for transposon suppression revealed developmentally regulated piRNA loci, some of which resemble transposon master control loci of Drosophila. MILI might be programmed by distinct piRNA populations at different stages of germ cell development, suggesting MILI plays an important role in meiotic prophase progression.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 80kDa PIWIL2 short isoform; Cancer/testis antigen 80; CT80; Miwi like; Miwi likw; piwi like homolog 2; PIWI-L2; piwi-like 2; piwi-like homolog 2; Piwi-like protein 2; piwi-like RNA-mediated gene silencing 2; piwil2-like protein; testicular tissue protein Li 141
基因别名: CT80; HILI; Mili; PIWIL1L; PIWIL2
UniProt ID: (Human) Q8TC59, (Mouse) Q8CDG1
Entrez Gene ID: (Human) 55124, (Rat) 306011, (Mouse) 57746
RNA 5'-end processing
multicellular organism development
spermatogenesis
germ-line stem cell population maintenance
gene silencing by RNA
piRNA metabolic process
DNA methylation involved in gamete generation
positive regulation of translation
oogenesis
meiotic cell cycle
positive regulation of meiosis I
positive regulation of histone H3-K14 acetylation
positive regulation of histone H3-K9 acetylation
pachytene
regulation of translation
cell differentiation
