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Bioss

PKA alpha + beta Polyclonal Antibody

查看其他5个PKA alpha/beta抗体

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说明书
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产品信息

BS-0520R

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:500
-

免疫组化（石蜡） (IHC (P))

1:200
-

免疫组化（冰冻） (IHC (F))

1:100-1:500
-

免疫细胞化学 (ICC/IF)

1:50-1:200
-

酶联免疫吸附实验 (ELISA)

1:500-1:1,000
-
产品规格

种属反应

Bovine, Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

KLH conjugated synthetic peptide derived from bovine PKA.

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein A

保存液

0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA

内含物

0.02% ProClin 300

保存条件

-20°C

运输条件

Ambient (domestic); Wet ice (international)

靶标信息

cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase (AMPK), which transduces the signal through phosphorylation of different target proteins. The inactive holoenzyme of AMPK is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits of AMPK have been identified in humans. PRKACB is a member of the Ser/Thr protein kinase family and is a catalytic subunit of AMPK.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: C-alpha-s; alternatively spliced isoform; cAMP-dependent protein kinase C beta; cAMP-dependent protein kinase catalytic subunit alpha; cAMP-dependent protein kinase catalytic subunit beta; cAMP-dependent protein kinase catalytic subunit C alpha; PKA C-alpha; PKA C-beta; protein kinase A; protein kinase A catalytic subunit; protein kinase A catalytic subunit beta; protein kinase beta-catalytic subunit; protein kinase, cAMP-dependent, alpha catalytic subunit; protein kinase, cAMP-dependent, beta catalytic subunit; protein kinase, cAMP-dependent, catalytic, alpha; protein kinase, cAMP-dependent, catalytic, beta; sperm cAMP-dependent protein kinase catalytic subunit; unnamed protein product

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基因别名: CAFD1; CAFD2; Cs-PKA; PKA C-beta; PKACA; PKACB; PKCA1; PKCD; PPNAD4; PRKACA; PRKACB

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UniProt ID: (Bovine) P00517, (Human) P17612, (Human) P22694, (Bovine) P05131, (Mouse) P05132, (Rat) P68182, (Mouse) P68181

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Entrez Gene ID: (Bovine) 282322, (Human) 5566, (Human) 5567, (Bovine) 282323, (Rat) 25636, (Mouse) 18747, (Rat) 293508, (Mouse) 18749

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功能
magnesium ion binding protein kinase activity protein serine/threonine kinase activity AMP-activated protein kinase activity cAMP-dependent protein kinase activity protein serine/threonine/tyrosine kinase activity protein binding ATP binding protein kinase binding protein domain specific binding manganese ion binding ubiquitin protein ligase binding nucleotide binding kinase activity transferase activity protein kinase A regulatory subunit binding channel activator activity protein serine kinase activity Rab GTPase binding protein complex binding transferase activity, transferring phosphorus-containing groups non-receptor serine/threonine protein kinase
参与通路
mesoderm formation neural tube closure mRNA processing protein phosphorylation peptidyl-serine phosphorylation peptidyl-threonine phosphorylation cellular response to heat regulation of osteoblast differentiation protein autophosphorylation positive regulation of protein export from nucleus sperm capacitation modulation of synaptic transmission regulation of proteasomal protein catabolic process regulation of protein processing positive regulation of cell cycle arrest cellular response to glucose stimulus cellular response to parathyroid hormone stimulus negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning regulation of bicellular tight junction assembly regulation of heart rate renal water homeostasis protein export from nucleus adenylate cyclase-activating G-protein coupled receptor signaling pathway adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion regulation of macroautophagy cytokine-mediated signaling pathway cellular potassium ion homeostasis cellular response to nutrient levels positive regulation of insulin secretion negative regulation of interleukin-2 production high-density lipoprotein particle assembly mitochondrial protein catabolic process interleukin-2-mediated signaling pathway TORC1 signaling proteasome-mediated ubiquitin-dependent protein catabolic process positive regulation of cholesterol biosynthetic process positive regulation of gluconeogenesis negative regulation of smoothened signaling pathway positive regulation of phagocytosis positive regulation of calcium-mediated signaling regulation of cell cycle regulation of cardiac muscle contraction cellular response to cold cellular response to glucagon stimulus cellular response to epinephrine stimulus cell communication by electrical coupling involved in cardiac conduction vascular endothelial cell response to laminar fluid shear stress postsynaptic modulation of chemical synaptic transmission cAMP/PKA signal transduction regulation of cardiac conduction negative regulation of TORC1 signaling negative regulation of glycolytic process through fructose-6-phosphate protein localization to lipid particle signal transduction adenylate cyclase-modulating G-protein coupled receptor signaling pathway G-protein coupled receptor signaling pathway positive regulation of cell proliferation regulation of cellular respiration negative regulation of meiotic cell cycle regulation of synaptic transmission, glutamatergic phosphorylation response to clozapine
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