AbboMax

PKC Polyclonal Antibody

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说明书
实验方案
问题与答案
技术支持
说明书
实验方案
问题与答案
技术支持
说明书
实验方案
问题与答案
技术支持
PKC Polyclonal Antibody

产品信息

500-9234

应用
建议稀释比
已发表文章

免疫印迹 (WB)

0.1-1 µg/mL
-

免疫组化（石蜡） (IHC (P))

2-10 µg/mL
-
产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

A synthetic peptide corresponding to C-term of human PKC beta
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.5 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS with proprietary stabilizer

内含物

0.01% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

Positive control: SKBR-3 cells

Cellular location: Cytoplasmic.

靶标信息

Protein Kinase C (PKC) is a multifunctional protein kinase that plays a critical regulatory role in a wide variety of cellular signaling processes. It is an ubiquitous calcium and phospholipid-dependent protein kinase. At least 10 PKC isoforms are reported to exist which are classified as conventional, novel, and a typical isoforms (Ohno and Nishizuka, 2002). PKC is one of the three major protein kinases (including CaM Kinase II and PKA) that mediate cellular responses to second messengers. PKC regulates a number of cellular functions including neurotransmitter synthesis and release, gene expression, ion channel function and synaptic plasticity (Lu et al., 1999; Grosshans et al., 2002; Nishizuka, 1995). The catalytic fragment of PKC (PKC-M) does not require Ca2+ or phosphatidylserine for its activity.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: 14 - 3 - 3 - zeta isoform; atypical protein kinase C; nPKC-zeta; protein kinase C zeta subspecies; Protein kinase C zeta type; protein kinase C, zeta

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基因别名: 14-3-3-zetaisoform; AI098070; aPKCzeta; C80388; nPKC-zeta; PKC-ZETA; PKC2; Pkcz; PRKCZ; r14-3-3; R74924; zetaPKC

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UniProt ID: (Human) Q05513, (Rat) P09217, (Mouse) Q02956

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Entrez Gene ID: (Human) 5590, (Rat) 25522, (Mouse) 18762

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功能
protein kinase activity protein serine/threonine kinase activity protein kinase C activity protein binding ATP binding potassium channel regulator activity protein kinase binding protein domain specific binding phospholipase binding insulin receptor substrate binding metal ion binding 14-3-3 protein binding nucleotide binding kinase activity transferase activity transferase activity, transferring phosphorus-containing groups non-receptor serine/threonine protein kinase
参与通路
microtubule cytoskeleton organization positive regulation of cell-matrix adhesion protein phosphorylation inflammatory response signal transduction transforming growth factor beta receptor signaling pathway long-term memory positive regulation of cell proliferation insulin receptor signaling pathway cell migration peptidyl-serine phosphorylation establishment of cell polarity negative regulation of protein complex assembly actin cytoskeleton reorganization activation of phospholipase D activity activation of protein kinase B activity positive regulation of interleukin-4 production negative regulation of apoptotic process positive regulation of T-helper 2 cell differentiation positive regulation of glucose import negative regulation of insulin receptor signaling pathway positive regulation of insulin receptor signaling pathway vesicle transport along microtubule negative regulation of peptidyl-tyrosine phosphorylation positive regulation of NF-kappaB transcription factor activity protein heterooligomerization negative regulation of hydrolase activity membrane depolarization membrane hyperpolarization long-term synaptic potentiation positive regulation of ERK1 and ERK2 cascade protein kinase C signaling protein localization to plasma membrane neuron projection extension positive regulation of excitatory postsynaptic potential positive regulation of T-helper 2 cell cytokine production positive regulation of interleukin-5 secretion positive regulation of interleukin-13 secretion positive regulation of interleukin-10 secretion cell surface receptor signaling pathway cellular response to insulin stimulus cellular protein localization intracellular signal transduction positive regulation of synaptic transmission positive regulation of protein transport phosphorylation
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