Invitrogen

PKC alpha Monoclonal Antibody (MC5), Biotin

查看其他37个PKC alpha抗体

产品信息

MA5-17705

应用

建议稀释比

已发表文章

免疫印迹 (WB)

Assay-dependent

-

酶联免疫吸附实验 (ELISA)

Assay-dependent

-

免疫沉淀 (IP)

Assay-dependent

-

产品规格

种属反应

Bovine, Human, Mouse

宿主/亚型

Mouse / IgG2a

分类

Monoclonal

类型

Antibody

克隆号

MC5

抗原

Mouse monoclonal antibodies raised against purified bovine brain protein kinase C alpha.

查看免疫原

偶联物

Biotin

形式

Liquid

浓度

0.1 mg/mL

纯化类型

Protein G

保存液

PBS with 4-5mg/mL BSA

内含物

0.02% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

RRID

AB_2539095

产品详细信息

MA5-17705 targets PKC alpha in ELISA, IP, and WB applications and shows reactivity with Human samples.

The MA5-17705 immunogen is mouse monoclonal antibodies raised against purified bovine brain protein kinase C alpha.

靶标信息

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca(2+) handling in myocytes.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: aging-associated gene 6; EC 2.7.11.13; FHC; FTH; FTHL6; kinase PKC-alpha; KPCA; MGC104426; PIG15; PKC III; PKC-A; PKC-alpha; PKC-III; PLIF; protein kinase C; Protein kinase C alpha type; protein kinase C, alpha; protein kinase c-alpha

基因别名: AAG6; AI875142; PKC-alpha; PKCA; PKRCA; PRKACA; PRKCA

UniProt ID: (Bovine) P04409, (Human) P17252, (Mouse) P20444

Entrez Gene ID: (Bovine) 282001, (Human) 5578, (Mouse) 18750

分子生物学功能: non-receptor serine/threonine protein kinase

angiogenesis positive regulation of endothelial cell proliferation protein phosphorylation apoptotic process cell adhesion positive regulation of endothelial cell migration positive regulation of cardiac muscle hypertrophy positive regulation of cell migration positive regulation of lipopolysaccharide-mediated signaling pathway negative regulation of glial cell apoptotic process positive regulation of macrophage differentiation positive regulation of angiogenesis positive regulation of cell adhesion positive regulation of mitotic cell cycle positive regulation of ERK1 and ERK2 cascade regulation of platelet aggregation positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway positive regulation of dense core granule biogenesis desmosome assembly mitotic nuclear envelope disassembly activation of adenylate cyclase activity negative regulation of adenylate cyclase activity peptidyl-serine phosphorylation platelet activation histone H3-T6 phosphorylation intracellular signal transduction regulation of mRNA stability positive regulation of blood vessel endothelial cell migration regulation of insulin secretion response to interleukin-1 apoptotic signaling pathway inactivation of MAPK activity response to reactive oxygen species negative regulation of protein phosphorylation positive regulation of protein phosphorylation regulation of the force of heart contraction chondrocyte differentiation negative regulation of protein kinase activity cellular calcium ion homeostasis regulation of muscle contraction learning or memory negative regulation of cell proliferation phosphorylation negative regulation of translation peptidyl-threonine phosphorylation central nervous system neuron axonogenesis neutrophil chemotaxis response to estradiol peptidyl-serine autophosphorylation response to ethanol negative regulation of heart contraction positive regulation of exocytosis negative regulation of glucose import negative regulation of insulin receptor signaling pathway protein autophosphorylation regulation of receptor-mediated endocytosis positive regulation of smooth muscle cell proliferation positive regulation of inflammatory response regulation of peptidyl-tyrosine phosphorylation induction of positive chemotaxis positive regulation of synapse assembly cellular response to carbohydrate stimulus intrinsic apoptotic signaling pathway

参与通路

protein kinase C activity calcium-dependent protein kinase C activity protein binding ATP binding zinc ion binding PDZ domain binding scaffold protein binding protein kinase activity protein serine/threonine kinase activity enzyme binding histone kinase activity (H3-T6 specific) nucleotide binding kinase activity transferase activity transferase activity, transferring phosphorus-containing groups metal ion binding