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产品信息
PA5-50637
| 应用 | 建议稀释比 | 已发表文章 |
|---|---|---|
免疫组化（石蜡） (IHC (P)) |
1:15-1:50 | - |
| 产品规格 | |
|---|---|
种属反应 |
Human, Mouse, Rat |
宿主/亚型 |
Rabbit / IgG |
分类 |
Polyclonal |
类型 |
Antibody |
抗原 |
Synthetic peptide corresponding to a region derived from internal residues of human phospholipase A2, group VI (cytosolic, calcium-independent) |
偶联物 |
Unconjugated |
形式 |
Liquid |
浓度 |
1.3 mg/mL |
纯化类型 |
Antigen affinity chromatography |
保存液 |
PBS, pH 7.4, with 40% glycerol |
内含物 |
0.05% sodium azide |
保存条件 |
-20°C |
RRID |
AB_2636090 |
产品详细信息
The antibody detects endogenous levels of total PLA2G6 protein.
靶标信息
The protein encoded by this gene is an A2 phospholipase, a class of enzyme that catalyzes the release of fatty acids from phospholipids. The encoded protein may play a role in phospholipid remodelling, arachidonic acid release, leukotriene and prostaglandin synthesis, fas-mediated apoptosis, and transmembrane ion flux in glucose-stimulated B-cells. Several transcript variants encoding multiple isoforms have been described, but the full-length nature of only two of them have been determined to date.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 2-lysophosphatidylcholine acylhydrolase; 85 kDa calcium-independent phospholipase A2; 85/88 kDa calcium-independent phospholipase A2; CaI-PLA2; Group VI phospholipase A2; GVI PLA2; Intracellular membrane-associated calcium-independent phospholipase A2 beta; iPLA2-beta; neurodegeneration with brain iron accumulation 2; Palmitoyl-CoA hydrolase; Patatin-like phospholipase domain-containing protein 9; phospholipase A2, group VI (cytosolic, calcium-independent); PNPLA9
基因别名: BB112799; CaI-PLA2; GVI; INAD1; iPLA(2)beta; iPLA2; IPLA2-VIA; iPLA2beta; NBIA2; NBIA2A; NBIA2B; PARK14; PLA2; PLA2G6; PLPLA9; PNPLA9
UniProt ID: (Human) Q9Y671, (Rat) P97570, (Mouse) P97819
Entrez Gene ID: (Human) 8398, (Rat) 360426, (Mouse) 53357
分子生物学功能:
phospholipase
positive regulation of protein phosphorylation
chemotaxis
positive regulation of cytosolic calcium ion concentration
memory
urinary bladder smooth muscle contraction
lipid catabolic process
antibacterial humoral response
cardiolipin biosynthetic process
response to endoplasmic reticulum stress
positive regulation of insulin secretion involved in cellular response to glucose stimulus
phosphatidylcholine acyl-chain remodeling
phosphatidylethanolamine acyl-chain remodeling
Fc-gamma receptor signaling pathway involved in phagocytosis
positive regulation of vasodilation
positive regulation of exocytosis
negative regulation of synaptic transmission, glutamatergic
maternal process involved in female pregnancy
positive regulation of protein kinase C signaling
positive regulation of release of cytochrome c from mitochondria
positive regulation of arachidonic acid secretion
regulation of store-operated calcium channel activity
positive regulation of ceramide biosynthetic process
lipid metabolic process
metabolic process
