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Abnova
PLEKHA1 Polyclonal Antibody, MaxPab™
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产品信息
H00059338-D01P
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
PLEKHA1 (NP_001001974.1, 1 a.a. approximately 404 a.a) full-length human protein.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MPYVDRQNRI CGFLDIEENE NSGKFLRRYF ILDTREDSFV WYMDNPQNLP SGSSRVGAIK LTYISKVSDA TKLRPKAEFC FVMNAGMRKY FLQANDQQDL VEWVNVLNKA IKITVPKQSD SQPNSDNLSR HGECGKKQVS YRTDIVGGVP IITPTQKEEV NECGESIDRN NLKRSQSHLP YFTPKPPQDS AVIKAGYCVK QGAVMKNWKR RYFQLDENTI GYFKSELEKE PLRVIPLKEV HKVQECKQSD IMMRDNLFEI VTTSRTFYVQ ADSPEEMHSW IKAVSGAIVA QRGPGRSASS EHPPGPSESK HAFRPTNAAT ATSHSTASRS NSLVSTFTME KRGFYESLAK VKPGNFKVQT VSPREPASKV TEQALLRPQS KNGPQEKDCD LVDLDDASLP VSDV
靶标信息
Phosphatidylinositol-4,5-bisphosphate 3-phosphatase adapter protein 1 (TAPP1) is a gene located on chromosome 1q25.2, encoding a protein involved in intracellular signaling pathways that regulate cellular processes such as proliferation, survival, and migration. TAPP1 is characterized by containing pleckstrin homology (PH) domains, which allow it to bind specifically to phosphoinositide lipids, particularly phosphatidylinositol (3,4) bisphosphate. This interaction is crucial for the localization of TAPP1 to cell membranes where it can act as an adaptor protein, modulating the activity of downstream signaling molecules and pathways. TAPP1 is expressed in various tissues and plays a role in immune cell function, influencing processes like cell motility and cytoskeletal dynamics. Research into TAPP1 focuses on its role in immune regulation and signaling, with implications for understanding its function in disease contexts such as cancer and autoimmune disorders where phosphoinositide signaling is disrupted.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: PH domain-containing family A member 1; pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1; Pleckstrin homology domain-containing family A member 1; Tandem PH domain-containing protein 1; TAPP-1
基因别名: AA960558; C920009D07Rik; PLEKHA1; TAPP1
UniProt ID: (Human) Q9HB21, (Mouse) Q8BUL6
Entrez Gene ID: (Human) 59338, (Mouse) 101476
luteinization
spermatogenesis
androgen metabolic process
estrogen metabolic process
female gonad development
post-embryonic development
phosphatidylinositol 3-kinase signaling
ruffle organization
Leydig cell differentiation
multicellular organism growth
establishment of protein localization
platelet-derived growth factor receptor signaling pathway
skeletal system morphogenesis
B cell receptor signaling pathway
negative regulation of protein kinase B signaling
palate development
face morphogenesis
cellular response to hydrogen peroxide
