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产品信息
PA5-66151
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant Human PLEKHG6. Recombinant protein control fragment (Product #RP-106834).
偶联物
形式
Liquid
浓度
0.3 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2663434
产品详细信息
Immunogen sequence: KAFGPPHEGPL QGLVASRIET YGGRHRASAQ STTGRLYPRG YPVLDPSRRR LQQYVPFARG SGQARGLSPM RLRDPEPEKR
Highest antigen sequence identity to the following orthologs - mouse 77%, rat 73%.
靶标信息
PLEKHG6 functions as a guanine nucleotide exchange factor activating the small GTPase RHOA, which, in turn, induces myosin filament formation. It activates RHOG but not activate RAC1, or to a much lower extent than RHOA and RHOG. Part of a functional unit, involving MyoGEF, MYH10 and RHOA, at the cleavage furrow to advance furrow ingression during cytokinesis. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with EZR, required for normal macropinocytosis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: MyoGEF; myosin II interacting GEF; myosin interacting guanine nucleotide exchange factor; Myosin-interacting guanine nucleotide exchange factor; PH domain-containing family G member 6; pleckstrin homology domain containing, family G (with RhoGef domain) member 6; Pleckstrin homology domain-containing family G member 6
基因别名: MyoGEF; PLEKHG6
UniProt ID: (Human) Q3KR16
Entrez Gene ID: (Human) 55200
