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Invitrogen
PLK4 Polyclonal Antibody
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产品信息
PA5-18012
应用
建议稀释比
已发表文章
产品规格
宿主/亚型
Goat
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide sequence (ATCIGEKIEDFKVGN) corresponding to the N-terminus amino acids of PLK4
偶联物
形式
Liquid
浓度
0.5 mg/mL
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
产品详细信息
This antibody is predicted to react with bovine and canine based on sequence homology.
靶标信息
PLK4 or polo-like kinase 4 is a member of the polo family of serine/threonine protein kinases which localizes to centrioles, complex microtubule-based structures found in centrosomes, and regulates centriole duplication during the cell cycle. The overexpression of PLK4 triggered the simultaneous formation of multiple procentrioles around each preexisting centriole which resulting in centriole amplification and thus, Plk4-induced centriole biogenesis in human cells. The reduced Plk4 gene dosage increases the probability of mitotic errors and cancer development.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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