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Immunogen sequence: MDEMATTQIS KDELDELKEA FAKVDLNSNG FICDYELHEL FKEANMPLPG YKVREIIQKL MLDGDRNKDG KISFDEFVYI FQEVKSSDIA KTFRKAINRK EGICALGGTS ELSSEGTQHS YSEEEKYAFV NWINKALEND PDCRHVIPMN PNTDDLFKAV GDGIVLCKMI NLSVPDTIDE RAINKKKLTP FIIQENLNLA LNSASAIGCH VVNIGAEDLR AGKPHLVLGL LWQIIKIGLF; Positive Samples: HeLa, MCF-7, BT-474, A-431, HepG2; Cellular Location: Cytoplasm
Phospholipid scramblases (PLS) translocate phospholipids bidirectionally between inner and outer leaflets of the plasma membrane and are implicated in apoptosis (1,2). Members of this family, PLS1 and PLS3 are both substrates of Protein kinase C (PKC) delta and are phosphorylated by PKC-delta during apoptosis. PKC-delta translocates to mitochondria during apoptosis and phosphorylates PLS3. Overexpression of PLS3 in the HEK293 cells enhanced apoptosis induced by UV-irradiation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: plastin 3 (T-isoform); plastin 3, T; Plastin-3; T fimbrin; T plastin; T-plastin
基因别名: AI115446; AL024105; BMND18; PLS3; T-fimbrin; T-plastin
UniProt ID: (Human) P13797, (Mouse) B1AX56
Entrez Gene ID: (Human) 5358, (Rat) 81748, (Mouse) 102866
分子生物学功能: non-motor actin binding protein