Plexin-B2 is a member of the Semaphorin receptor family. The semaphorin family consists of membrane and secreted proteins involved in attraction and repulsion of neuronal guidance cues. Plexin-B1 is a transmembrane protein that can be cleaved converting the single chain precursor into a heterodimeric receptor. It has been shown to bind Sema4D/CD100 and is involved in axon development in mouse embryos. Sema4D also plays a role in the immune system interacting with CD72. Plexin-B2's possible role in the immune system has not been characterized.
蛋白别名: differentially expressed in brain tumors; MM1; MM1KIAA0315dJ402G11.3; Plexin-B2
基因别名: Debt; dJ402G11.3; KIAA0315; MM1; Nbla00445; PLEXB2; plexin-B2; PLXNB2