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Invitrogen
POLB Polyclonal Antibody
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产品信息
PA5-78112
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein encompassing a sequence within the center region of human DNA polymerase beta. The exact sequence is proprietary.
偶联物
形式
Liquid
浓度
1 mg/mL
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
产品详细信息
Positive Control: unboiled hPOLB-transfected 293T cells, MCF7, MDA-MB-231, MDA-MB-361, MDA-MB-453, T47D, ZR-75-1, 293T, HeLa, HT29, U2OS
Predicted Reactivity: Rat (94%), Zebrafish (83%), Xenopus laevis (83%), Rhesus Monkey (99%), Bovine (97%)
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
DNA polymerase beta comprises an amino-terminal 8- kDa domain and a carboxy-terminal 31- kDa domain. The N-terminal ssDNA binding domain has a deoxyribose phosphodiesterase activity while the C-terminal domain has a nucleotidyltransferase activity. Mammalian DNA polymerase beta, a DNA repair polymerase, is constitutively expressed in cultured cells, but treatment of cells with the DNA-alkylating agents such as N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) or methyl methanesulfonate up-regulates beta-pol level. DNA polymerase beta fills single nucleotide gaps in DNA produced by the base excision repair pathway of mammalian cells.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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