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Proteintech
POLI Polyclonal Antibody
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产品信息
13635-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
POLI Fusion Protein Ag4563 (1-340 aa encoded by BC032662)
偶联物
形式
Liquid
浓度
0.18 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: MELADVGAA ASSQGVHDQV LPTPNASSRV IVHVDLDCFY AQVEMISNPE LKDKPLGVQQ KYLVVTCNYE ARKLGVKKLM NVRDAKEKCP QLVLVNGEDL TRYREMSYKV TELLEEFSPV VERLGFDENF VDLTEMVEKR LQQLQSDELS AVTVSGHVYN NQSINLLDVL HIRLLVGSQI AAEMREAMYN QLGLTGCAGV ASNKLLAKLV SGVFKPNQQT VLLPESCQHL IHSLNHIKEI PGIGYKTAKC LEALGINSVR DLQTFSPKIL EKELGISVAQ RIQKLSFGED NSPVILSGPP QSFSEEDSFK KCSSEVEAKN KIEELLASLL NRVCQDGRKP H (1-340 aa encoded by BC032662)
靶标信息
Error-prone DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Favors Hoogsteen base-pairing in the active site. Inserts the correct base with high-fidelity opposite an adenosine template. Exhibits low fidelity and efficiency opposite a thymidine template, where it will preferentially insert guanosine. May play a role in hypermutation of immunoglobulin genes. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but may not have lyase activity.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: DNA polymerase iota; Eta2; polymerase (DNA directed) iota; polymerase (DNA) iota; polymerase (DNA-directed), iota; RAD 30B; RAD30; RAD30 homolog B
基因别名: POLI; RAD30B; RAD3OB
UniProt ID: (Human) Q9UNA4, (Mouse) Q6R3M4
Entrez Gene ID: (Human) 11201, (Mouse) 26447, (Rat) 291526
