Immunogen sequence: VAINRLLSMG QLDLLRSNTG LLYRIKDSQN AGKMKGSDNQ EKLVYQIIED AGNKGIWSRD IRYKSNLPLT EINK
Highest antigen sequence identity to the following orthologs: Mouse - 100%, Rat - 100%.
The human POLR3F is a component of RNA III polymerase. RNA polymerase III transcribes many essential, small, noncoding RNAs, including the 5S rRNAs and tRNAs. While most pol III-transcribed genes are found scattered throughout the linear chromosome maps or in multiple linear clusters, there is increasing evidence that many of these genes prefer to be spatially clustered, often at or near the nucleolus. This association could create an environment that fosters the coregulation of transcription by pol III with transcription of the large ribosomal RNA repeats by RNA polymerase I (pol I) within the nucleolus. Given the high number of pol III-transcribed genes in all eukaryotic genomes, the spatial organization of these genes is likely to affect a large portion of the other genes in a genome. POLR3F has also been recently identified as an HIV dependency factor (HDF), suggesting that POLR3F may be an important drug target in HIV treatment. At least two isoforms of POLR3F are known to exist.
蛋白别名: DNA-directed RNA polymerase III subunit F; DNA-directed RNA polymerase III subunit RPC6; polymerase (RNA) III (DNA directed) polypeptide F, 39 kDa; polymerase (RNA) III subunit F; RNA polymerase III 39 kDa subunit; RNA polymerase III C39 subunit; RNA polymerase III subunit C6; RPC39
基因别名: POLR3F; RPC39; RPC6
UniProt ID: (Human) Q9H1D9
Entrez Gene ID: (Human) 10621
分子生物学功能: DNA-directed RNA polymerase