Invitrogen

PP1 alpha/beta/gamma Recombinant Rabbit Monoclonal Antibody (HL1677)

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说明书
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问题与答案
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产品信息

MA5-47138

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:500-1:3,000
-
产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

Expression System

HEK293 cells

分类

Recombinant Monoclonal

类型

Antibody

克隆号

HL1677

抗原

Recombinant fragment of human PP1

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein A

保存液

PBS

内含物

no preservative

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2938210

产品详细信息

Store as concentrated solution.

Centrifuge briefly prior to opening vial.

靶标信息

PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription|Increased PP1 activity has been observed in the end stage of heart failure|Studies suggest that PP1 is an important regulator of cardiac function and that PP1 deregulation is implicated in diabetes and multiple types of cancer|PP1 alpha is one of the three catalytic subunits of protein phosphatase 1 (PP1)|This broadly expressed gene encodes the alpha subunit of the PP1 complex that associates with over 200 regulatory proteins to form holoenzymes which dephosphorylate their biological targets with high specificity|PP1 beta encodes the beta isozyme and PP1 gamma encodes the gamma isozyme

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: casein kinase 1, alpha 1; casein kinase 1, alpha 1-like; casein kinase I alpha S-like; Casein kinase I isoform alpha; Casein kinase I isoform alpha-like; CASP-1; CASP1 nirs variant 1; caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase); Caspase-1; CK1; CKI-alpha; CKI-alpha-like; clock regulator kinase; down-regulated in lung cancer; epididymis secretory sperm binding protein Li 77p; HEL-S-80p; ICE; IL-1 beta-converting enzyme; IL-1BC; IL1B-convertase; interleukin 1, beta, convertase; interleukin 1-B converting enzyme; Interleukin-1 beta convertase; Interleukin-1 beta-converting enzyme; NSLH2; p45; PP-1A; PP-1B; PP-1G; PP1A; PP1alpha; PP1B; PP1beta; PP1C; PPP1A; PPP1CD; PPP1G; protein phosphatase 1 catalytic subunit alpha; protein phosphatase 1 catalytic subunit beta; protein phosphatase 1 catalytic subunit gamma

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基因别名: CASP1; CK1; CK1a; CKIa; CSNK1A1; CSNK1A1L; HEL-S-77p; HLCDGP1; ICE; IL1BC; IL1BCE; P45; PRO2975

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UniProt ID: (Human) P29466, (Human) P48729, (Human) Q8N752

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Entrez Gene ID: (Human) 834, (Human) 1452, (Human) 122011

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功能
endopeptidase activity cysteine-type endopeptidase activity protein binding cysteine-type endopeptidase activator activity involved in apoptotic process cysteine-type endopeptidase activity involved in apoptotic process protein kinase activity protein serine/threonine kinase activity ATP binding kinase activity protease non-receptor serine/threonine protein kinase
参与通路
response to hypoxia proteolysis apoptotic process activation of cysteine-type endopeptidase activity involved in apoptotic process signal transduction regulation of autophagy protein processing response to lipopolysaccharide interleukin-1 beta production response to ATP regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of interleukin-1 alpha secretion positive regulation of interleukin-1 beta secretion regulation of inflammatory response mitochondrial depolarization membrane hyperpolarization pyroptosis cellular response to mechanical stimulus cellular response to organic substance programmed necrotic cell death toxin transport protein phosphorylation phagocytosis Golgi organization mitotic nuclear division cell surface receptor signaling pathway regulation of cell shape Wnt signaling pathway peptidyl-serine phosphorylation positive regulation of proteasomal ubiquitin-dependent protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process intermediate filament cytoskeleton organization cell division negative regulation of canonical Wnt signaling pathway regulation of GTP binding beta-catenin destruction complex assembly beta-catenin destruction complex disassembly cell morphogenesis
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