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Invitrogen
PPARGC1A Polyclonal Antibody
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产品信息
PA5-66559
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant Human PGC1 alpha
偶联物
形式
Liquid
浓度
0.1 mg/mL
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
产品详细信息
Immunogen sequence: FGHPSQAVFDD EADKTGELRD SDFSNEQFSK LPMFINSGLA MDGLFDDSED ESDKLSYPWD GTQSYSLFNV SPSCSSFNSP CRDSVSRPKS L
Highest antigen sequence identity to the following orthologs - mouse 90%, rat 90%.
靶标信息
PGC1 alpha is a transcriptional coactivator that regulates the genes involved in energy metabolism. It interacts with PPARgamma, which permits it's interaction with multiple transcription factors. PGC-1 Alpha can interact with, and regulate the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. It may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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