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Proteintech
PPARGC1B Polyclonal Antibody
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产品信息
22378-1-AP
产品规格
种属反应
Human,
Mouse
已发表种属
Fish,
Goat,
Mouse,
Pig
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
PPARGC1B Fusion Protein Ag17566 (1-350 aa encoded by BC132971)
偶联物
形式
Liquid
浓度
0.31 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: MAGNDCGAL LDEELSSFFL NYLADTQGGG SGEEQLYADF PELDLSQLDA SDFDSATCFG ELQWCPENSE TEPNQYSPDD SELFQIDSEN EALLAELTKT LDDIPEDDVG LAAFPALDGG DALSCTSASP APSSAPPSPA PEKPSAPAPE VDELSLLQKL LLATSYPTSS SDTQKEGTAW RQAGLRSKSQ RPCVKADSTQ DKKAPMMQSQ SRSCTELHKH LTSAQCCLQD RGLQPPCLQS PRLPAKEDKE PGEDCPSPQP APASPRDSLA LGRADPGAPV SQEDMQAMVQ LIRYMHTYCL PQRKLPPQTP EPLPKACSNP SQQVRSRPWS RHHSKASWAE FSILRELLAQ D (1-350 aa encoded by BC132971)
靶标信息
PGC-1 beta is a tissue specific co-activator that enhances the activity of estrogen receptor alpha. The co-activation function relies on a bipartite transcriptional activation domain and two LXXLL motifs that interact with the AR2 domain of ER-alpha in an estrogen-dependent manner. Ectopic expression of this protein has been shown to lead to increased mitochondrial number and basal oxygen consumption.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: ERR ligand 1; peroxisome proliferator-activated receptor gamma coactivator 1 beta; Peroxisome proliferator-activated receptor gamma coactivator 1-beta; peroxisome proliferator-activated receptor gamma, coactivator 1 beta; pgc-1 beta; PGC-1-beta; PGC-1-related estrogen receptor alpha coactivator; PGC-1beta; PGC-1beta/ERRL1; PPAR gamma coactivator-1beta protein; PPAR-gamma coactivator 1-beta; PPARgamma coactivator 1 beta; PPARGC-1-beta
基因别名: 4631412G21Rik; ERRL1; PERC; PGC-1(beta); PGC1; PGC1B; PPARGC1; PPARGC1B
UniProt ID: (Human) Q86YN6, (Mouse) Q8VHJ7
Entrez Gene ID: (Human) 133522, (Mouse) 170826
nucleotide binding
RNA polymerase II transcription cofactor activity
RNA binding
transcription factor binding
estrogen receptor binding
ligand-dependent nuclear receptor transcription coactivator activity
receptor activator activity
AF-2 domain binding
nucleic acid binding
protein binding
transcription cofactor
ossification
regulation of transcription, DNA-templated
transcription from mitochondrial promoter
mitochondrion organization
actin filament organization
positive regulation of alkaline phosphatase activity
intracellular estrogen receptor signaling pathway
cellular response to reactive oxygen species
positive regulation of phosphorylation
positive regulation of osteoclast differentiation
positive regulation of bone resorption
negative regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of sequence-specific DNA binding transcription factor activity
response to glucocorticoid
response to cAMP
bone trabecula formation
positive regulation of receptor activity
transcription, DNA-templated
transcription from RNA polymerase II promoter
positive regulation of transcription, DNA-templated
