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Invitrogen
PPARGC1B Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-85594
产品规格
种属反应
Human,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein encompassing a sequence within the center region of human PGC1 beta. The exact sequence is proprietary.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7, with 20% glycerol
内含物
0.025% ProClin 300
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Keep as concentrated solution.
Predicted reactivity: Mouse (82%), Rat (83%).
Positive Control: rat heart.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
PGC-1 beta is a tissue specific co-activator that enhances the activity of estrogen receptor alpha. The co-activation function relies on a bipartite transcriptional activation domain and two LXXLL motifs that interact with the AR2 domain of ER-alpha in an estrogen-dependent manner. Ectopic expression of this protein has been shown to lead to increased mitochondrial number and basal oxygen consumption.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: peroxisome proliferative activated receptor, gamma, coactivator 1 beta; Peroxisome proliferator-activated receptor gamma coactivator 1-beta; peroxisome proliferator-activated receptor gamma coactivator 1beta-2a; pgc-1 beta; PGC-1-beta; PGC-1-related estrogen receptor alpha coactivator; PPAR-gamma coactivator 1-beta; PPARGC-1-beta
基因别名: PERC; PGC1; PGC1B; PGC1beta; PPARGC1; PPARGC1B
UniProt ID: (Rat) Q811R2
Entrez Gene ID: (Rat) 291567
nucleotide binding
RNA polymerase II transcription cofactor activity
molecular_function
nucleic acid binding
RNA binding
transcription factor binding
estrogen receptor binding
ligand-dependent nuclear receptor transcription coactivator activity
receptor activator activity
AF-2 domain binding
transcription cofactor
ossification
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
transcription from mitochondrial promoter
actin filament organization
positive regulation of alkaline phosphatase activity
intracellular estrogen receptor signaling pathway
cellular response to reactive oxygen species
positive regulation of phosphorylation
positive regulation of osteoclast differentiation
positive regulation of bone resorption
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of sequence-specific DNA binding transcription factor activity
response to glucocorticoid
response to cAMP
bone trabecula formation
positive regulation of receptor activity
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Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
