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The PRH1 gene encodes a member of the heterogeneous family of proline-rich salivary glycoproteins. The encoded preproprotein undergoes proteolytic processing to generate one or more mature isoforms before secretion from the parotid and submandibular/sublingual glands. In western population this locus is commonly biallelic and encodes proline-rich protein (PRP) isoforms, PRP-1 and PRP-2. The reference genome encodes the PRP-1 allele. Certain alleles of this gene are associated with susceptibility to dental caries. This gene is located in a cluster of closely related salivary proline-rich proteins on chromosome 12.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: acidic salivary proline-rich protein, HaeIII type, 2; Db-s; Pa; Parotid acidic protein; Parotid double-band protein; Parotid isoelectric focusing variant protein; Parotid proline-rich protein 1/2; PIF-S; Pr1/Pr2; proline-rich protein HaeIII subfamily 2; Protein C; PRP-1/PRP-2; Salivary acidic proline-rich phosphoprotein 1/2
基因别名: Pr; pr1/Pr2; PRH1; PRH2; PRP-1/PRP-2
UniProt ID: (Human) P02810
Entrez Gene ID: (Human) 5555