Product References
Neuronal loss of NCLX-dependent mitochondrial calcium efflux mediates age-associated cognitive decline.
iScience
Jadiya P,Cohen HM,Kolmetzky DW,Kadam AA,Tomar D,Elrod JW
MA1-045 was used in Western Blotting to demonstrate that loss of NCLX-dependent mCa2+ efflux alone is sufficient to induce an Alzheimer's disease-like pathology and highlights the promise of therapies targeting mCa2+ exchange.
Fri Mar 17 00:00:00 UTC 2023
Neurexin-3 subsynaptic densities are spatially distinct from Neurexin-1 and essential for excitatory synapse nanoscale organization in the hippocampus.
Nature communications
Lloyd BA,Han Y,Roth R,Zhang B,Aoto J
MA1-045 was used in Immunocytochemistry-immunofluorescence to identify neurexin-3 as a critical presynaptic adhesion molecule that regulates excitatory synapse nano-organization in hippocampus.
Sat Aug 05 00:00:00 UTC 2023
SorCS1 inhibits amyloid-β binding to neurexin and rescues amyloid-β-induced synaptic pathology.
Life science alliance
Lee AK,Yi N,Khaled H,Feller B,Takahashi H
MA1-045 was used in Immunocytochemistry-immunofluorescence to suggest a role for SorCS1 in the rescue of AβO-induced NRX dysfunction and synaptic pathology, providing the basis for a novel potential therapeutic strategy for Alzheimer's disease.
Sat Apr 01 00:00:00 UTC 2023
Excitation-inhibition imbalance disrupts visual familiarity in amyloid and non-pathology conditions.
Cell reports
Niraula S,Doderer JJ,Indulkar S,Berry KP,Hauser WL,L'Esperance OJ,Deng JZ,Keeter G,Rouse AG,Subramanian J
MA1-045 was used in Immunohistochemistry to show that disrupted familiarity occurs when the fraction of high-responsive neurons and the persistence of neural representation of a memory-associated stimulus are not constrained.
Tue Jan 31 00:00:00 UTC 2023
A Neuroligin-1 mutation associated with Alzheimer's disease produces memory and age-dependent impairments in hippocampal plasticity.
iScience
Arias-Aragón F,Tristán-Clavijo E,Martínez-Gallego I,Robles-Lanuza E,Coatl-Cuaya H,Martín-Cuevas C,Sánchez-Hidalgo AC,Rodríguez-Moreno A,Martinez-Mir A,Scholl FG
MA1-045 was used in Western Blot to suggest that decreased Nlgn1 may contribute to the synaptic and memory deficits in AD.
Fri Jun 16 00:00:00 UTC 2023
Neuron-derived extracellular vesicles contain synaptic proteins, promote spine formation, activate TrkB-mediated signalling and preserve neuronal complexity.
Journal of extracellular vesicles
Solana-Balaguer J,Campoy-Campos G,Martín-Flores N,Pérez-Sisqués L,Sitjà-Roqueta L,Kucukerden M,Gámez-Valero A,Coll-Manzano A,Martí E,Pérez-Navarro E,Alberch J,Soriano J,Masana M,Malagelada C
MA1-045 was used in Immunocytochemistry to provide evidence that primary neurons uptake neuron-derived EVs in the soma, dendrites, and even in the dendritic spines, and carry synaptic proteins.
Fri Sep 01 00:00:00 UTC 2023
Neuron-derived extracellular vesicles contain synaptic proteins, promote spine formation, activate TrkB-mediated signalling and preserve neuronal complexity.
Journal of extracellular vesicles
Solana-Balaguer J,Campoy-Campos G,Martín-Flores N,Pérez-Sisqués L,Sitjà-Roqueta L,Kucukerden M,Gámez-Valero A,Coll-Manzano A,Martí E,Pérez-Navarro E,Alberch J,Soriano J,Masana M,Malagelada C
MA1-045 was used in Immunocytochemistry to provide evidence that primary neurons uptake neuron-derived EVs in the soma, dendrites, and even in the dendritic spines, and carry synaptic proteins.
Fri Sep 01 00:00:00 UTC 2023
Interhemispheric cortical long-term potentiation in the auditory cortex requires heterosynaptic activation of entorhinal projection.
iScience
Li X,He L,Hu X,Huang F,Wang X,Chen M,Yoon EG,Bello ST,Chen T,Chen X,Tang P,Chen C,Qu J,He J
MA1-045 was used in Immunohistochemistry to reveal the fundamental corticocortical connection properties.
Fri Apr 21 00:00:00 UTC 2023
Dendritic spine formation and synapse maturation in transcription factor-induced human iPSC-derived neurons.
iScience
Lin W,Shiomoto S,Yamada S,Watanabe H,Kawashima Y,Eguchi Y,Muramatsu K,Sekino Y
MA1-045 was used in Immunocytochemistry-immunofluorescence to determine the transcriptional and morphological sequences of key developmental events associated with spinogenesis, including the conversion of drebrin to its brain-specific isoform A and the N-methyl-D-aspartate (NMDA) receptor subunit switch.
Fri Apr 21 00:00:00 UTC 2023
Prepubescent female rodents have enhanced hippocampal LTP and learning relative to males, reversing in adulthood as inhibition increases.
Nature neuroscience
Le AA,Lauterborn JC,Jia Y,Wang W,Cox CD,Gall CM,Lynch G
MA1-045 was used in Antibody array to conclude that puberty has opposite consequences for plasticity in the two sexes, albeit through different routes.
Tue Feb 01 00:00:00 UTC 2022
Neurodegeneration and astrogliosis in the entorhinal cortex in Alzheimer's disease: Stereological layer-specific assessment and proteomic analysis.
Alzheimer's & dementia : the journal of the Alzheimer's Association
Astillero-Lopez V,Gonzalez-Rodriguez M,Villar-Conde S,Flores-Cuadrado A,Martinez-Marcos A,Ubeda-Banon I,Saiz-Sanchez D
Thu Dec 01 00:00:00 UTC 2022
Neurodegeneration and astrogliosis in the entorhinal cortex in Alzheimer's disease: Stereological layer-specific assessment and proteomic analysis.
Alzheimer's & dementia : the journal of the Alzheimer's Association
Astillero-Lopez V,Gonzalez-Rodriguez M,Villar-Conde S,Flores-Cuadrado A,Martinez-Marcos A,Ubeda-Banon I,Saiz-Sanchez D
Thu Dec 01 00:00:00 UTC 2022
A novel bio-inspired strategy to prevent amyloidogenesis and synaptic damage in Alzheimer's disease.
Molecular psychiatry
Catania M,Colombo L,Sorrentino S,Cagnotto A,Lucchetti J,Barbagallo MC,Vannetiello I,Vecchi ER,Favagrossa M,Costanza M,Giaccone G,Salmona M,Tagliavini F,Di Fede G
MA1-045 was used in Antibody array to open the way to an unprecedented and promising approach for the prevention of the disease in humans.
Thu Dec 01 00:00:00 UTC 2022
Suppression of exaggerated NMDAR activity by memantine treatment ameliorates neurological and behavioral deficits in aminopeptidase P1-deficient mice.
Experimental & molecular medicine
Bae YS,Yoon SH,Kim YS,Oh SP,Song WS,Cha JH,Kim MH
MA1-045 was used in Western Blotting to investigate the synaptic mechanisms of and pharmacological interventions for the neurological complications of most Inborn errors of metabolism.
Mon Aug 01 00:00:00 UTC 2022
Topologically controlled circuits of human iPSC-derived neurons for electrophysiology recordings.
Lab on a chip
Girardin S,Clément B,Ihle SJ,Weaver S,Petr JB,Mateus JC,Duru J,Krubner M,Forró C,Ruff T,Fruh I,Müller M,Vörös J
MA1-045 was used in Immunohistochemistry to build arrays of topologically controlled circuits of human induced pluripotent stem cell-derived neurons.
Tue Mar 29 00:00:00 UTC 2022
High throughput 3D gel-based neural organotypic model for cellular assays using fluorescence biosensors.
Communications biology
Kundu S,Boutin ME,Strong CE,Voss T,Ferrer M
MA1-045 was used in Flow Cytometry, Immunocytochemistry, Immunoprecipitation, Western Blot, Immunohistochemistry to demonstrate that the drug responses of 3D gel-based neural models are like those expected from in-vivo data, and in some cases, in contrast to those observed in the equivalent 2D neural models.
Sat Nov 12 00:00:00 UTC 2022
ATase inhibition rescues age-associated proteotoxicity of the secretory pathway.
Communications biology
Murie M,Peng Y,Rigby MJ,Dieterich IA,Farrugia MA,Endresen A,Bhattacharyya A,Puglielli L
MA1-045 was used in Immunohistochemistry to propose that ATase-targeting approaches might offer a translational pathway for many age-associated proteopathies affecting the ER/secretory pathway.
Fri Feb 25 00:00:00 UTC 2022
R1441C and G2019S LRRK2 knockin mice have distinct striatal molecular, physiological, and behavioral alterations.
Communications biology
Xenias HS,Chen C,Kang S,Cherian S,Situ X,Shanmugasundaram B,Liu G,Scesa G,Savio Chan C,Parisiadou L
MA1-045 was used in Western Blotting to show that increased synaptic PKA activities in the R1441C and not G2019S mice underlie the specific alterations in motor learning deficits.
Thu Nov 10 00:00:00 UTC 2022
Extracellular Cardiolipin Modulates Select Immune Functions of Astrocytes in Toll-Like Receptor (TLR) 4-Dependent Manner.
Mediators of inflammation
Murray TE,Wenzel TJ,Simtchouk S,Greuel BK,Gibon J,Klegeris A
MA1-045 was used in Western Blotting to extend the list of cell type functions of which CL modulates and provides evidence that CL, or liposomes containing this phospholipid can be used to modulate specific neuroimmune functions of astrocytes.
Tue Apr 05 00:00:00 UTC 2022
Dysfunction of cerebellar microglia in Ataxia-telangiectasia.
Glia
Levi H,Bar E,Cohen-Adiv S,Sweitat S,Kanner S,Galron R,Mitiagin Y,Barzilai A
MA1-045 was used in Western Blotting to validate the roles of glial cells in cerebellar attrition in Ataxia-telangiectasia.
Tue Mar 01 00:00:00 UTC 2022
Decreased synapse-associated proteins are associated with the onset of epileptic memory impairment in endothelial CDK5-deficient mice.
MedComm
Li ZM,Liu XX,Li C,Wei ZC,Shi Y,Song HY,Chen X,Zhang Y,Li JW,Zhu RF,Hu BH,Ye WF,Huo D,Jiang GJ,Sasaki T,Zhang L,Han F,Lu YM
MA1-045 was used in Immunohistochemistry to elucidate a potential mechanism of memory deficits in epilepsy, and pharmacological reversal of synaptic pathology targeting might provide a new therapeutic intervention for epileptic memory deficits.
Thu Sep 01 00:00:00 UTC 2022
Decreased synapse-associated proteins are associated with the onset of epileptic memory impairment in endothelial CDK5-deficient mice.
MedComm
Li ZM,Liu XX,Li C,Wei ZC,Shi Y,Song HY,Chen X,Zhang Y,Li JW,Zhu RF,Hu BH,Ye WF,Huo D,Jiang GJ,Sasaki T,Zhang L,Han F,Lu YM
MA1-045 was used in Immunohistochemistry to elucidate a potential mechanism of memory deficits in epilepsy, and pharmacological reversal of synaptic pathology targeting might provide a new therapeutic intervention for epileptic memory deficits.
Thu Sep 01 00:00:00 UTC 2022
α2δ-4 and Cachd1 Proteins Are Regulators of Presynaptic Functions.
International journal of molecular sciences
Ablinger C,Eibl C,Geisler SM,Campiglio M,Stephens GJ,Missler M,Obermair GJ
MA1-045 was used in Immunocytochemistry-immunofluorescence to investigate the presynaptic functions of α2δ-4 and Cachd1 by expressing individual proteins in cultured hippocampal neurons.
Wed Aug 31 00:00:00 UTC 2022
Lack of UBE3A-Mediated Regulation of Synaptic SK2 Channels Contributes to Learning and Memory Impairment in the Female Mouse Model of Angelman Syndrome.
Neural plasticity
Sun J,Liu Y,Hao X,Baudry M,Bi X
MA1-045 was used in Immunohistochemistry (Frozen) to indicate that like male Angelman syndrome mice, female Angelman syndrome mice showed significant impairment in both synaptic plasticity and fear-conditioning memory due to increased levels of synaptic SK2 channels.
Mon Oct 17 00:00:00 UTC 2022
Gestational high fat diet protects 3xTg offspring from memory impairments, synaptic dysfunction, and brain pathology.
Molecular psychiatry
Di Meco A,Jelinek J,Lauretti E,Curtis ME,Issa JJ,Praticò D
MA1-045 was used in Immunohistochemistry to investigate if gestational high fat diet protects offspring against the development of the Alzheimer''s disease phenotype.
Mon Nov 01 00:00:00 UTC 2021
Soluble β-amyloid impaired the GABA inhibition by mediating KCC2 in early APP/PS1 mice.
Bioscience trends
Zhou Y,Cheng Y,Li Y,Ma J,Wu Z,Chen Y,Mei J,Chen M
MA1-045 was used in Western Blot to explore the relation of GABAergic transmission and soluble Aβ in early APP/PS1 mice.
Sun Nov 21 00:00:00 UTC 2021
Biallelic variants in TMEM222 cause a new autosomal recessive neurodevelopmental disorder.
Genetics in medicine : official journal of the American College of Medical Genetics
Polla DL,Farazi Fard MA,Tabatabaei Z,Habibzadeh P,Levchenko OA,Nikuei P,Makrythanasis P,Hussain M,von Hardenberg S,Zeinali S,Fallah MS,Schuurs-Hoeijmakers JHM,Shahzad M,Fatima F,Fatima N,Kaat LD,Bruggenwirth HT,Fleming LR,Condie J,Ploski R,Pollak A,Pilch J,Demina NA,Chukhrova AL,Sergeeva VS,Venselaar H,Masri AT,Hamamy H,Santoni FA,Linda K,Ahmed ZM,Nadif Kasri N,de Brouwer APM,Bergmann AK,Hethey S,Yavarian M,Ansar M,Riazuddin S,Riazuddin S,Silawi M,Ruggeri G,Pirozzi F,Eftekhar E,Taghipour Sheshdeh A,Bahramjahan S,Mirzaa GM,Lavrov AV,Antonarakis SE,Faghihi MA,van Bokhoven H
MA1-045 was used in Immunocytochemistry-immunoflourescence to elucidate the novel molecular cause in families with a new autosomal recessive neurodevelopmental disorder.
Thu Jul 01 00:00:00 UTC 2021
Rapid Aging in the Perforant Path Projections to the Rodent Dentate Gyrus.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Amani M,Lauterborn JC,Le AA,Cox BM,Wang W,Quintanilla J,Cox CD,Gall CM,Lynch G
MA1-045 was used in Immunohistochemistry to suggest that the loss of plasticity and related trophic signaling predispose the entorhinal neurons to functional decline in relatively young adulthood.
Wed Mar 10 00:00:00 UTC 2021
Impaired Learning and Memory Ability Induced by a Bilaterally Hippocampal Injection of Streptozotocin in Mice: Involved With the Adaptive Changes of Synaptic Plasticity.
Frontiers in aging neuroscience
Qi CC,Chen XX,Gao XR,Xu JX,Liu S,Ge JF
MA1-045 was used in Western Blot to establish an AD-like mice model, investigate the behavioral performance, and explore the potential mechanism.
Sat Mar 20 00:00:00 UTC 2021
The 4-(Phenylsulfanyl) butan-2-one Improves Impaired Fear Memory Retrieval and Reduces Excessive Inflammatory Response in Triple Transgenic Alzheimer's Disease Mice.
Frontiers in aging neuroscience
Varinthra P,Ganesan K,Huang SP,Chompoopong S,Eurtivong C,Suresh P,Wen ZH,Liu IY
MA1-045 was used in Western Blotting to demonstrate that the compound 4-(phenylsulfanyl) butan-2-one (4-PSB-2) is effective in enhancing fear memory retrieval of wild-type and 3xTg-AD mice by reducing the expression of TNF-α, COX-2, and iNOS. It also found that 4-PSB-2 helps increase dendritic spine density, postsynaptic density protein-95 (PSD-95) expression, and long-term potentiation (LTP) in the hippocampus of 3xTg-AD mice.
Tue Feb 23 00:00:00 UTC 2021
ADAM10 hyperactivation acts on piccolo to deplete synaptic vesicle stores in Huntington's disease.
Human molecular genetics
Cozzolino F,Vezzoli E,Cheroni C,Besusso D,Conforti P,Valenza M,Iacobucci I,Monaco V,Birolini G,Bombaci M,Falqui A,Saftig P,Rossi RL,Monti M,Cattaneo E,Zuccato C
MA1-045 was used in Western Blot to indicate that presynaptic ADAM10 and PCLO are a relevant component of HD pathogenesis.
Thu Jun 17 00:00:00 UTC 2021
Increased excitatory to inhibitory synaptic ratio in parietal cortex samples from individuals with Alzheimer's disease.
Nature communications
Lauterborn JC,Scaduto P,Cox CD,Schulmann A,Lynch G,Gall CM,Keene CD,Limon A
MA1-045 was used in Immunohistochemistry to investigate excitatory to inhibitory synaptic ratios in the pathogenesis of Azlheimer's disease.
Mon May 10 00:00:00 UTC 2021
Adulthood systemic inflammation accelerates the trajectory of age-related cognitive decline.
Aging
Barter J,Kumar A,Bean L,Ciesla M,Foster TC
MA1-045 was used in Western Blotting to suggest that the history of systemic inflammation is one component of environmental factors that contribute to the resilience or susceptibility to age-related brain changes and associated trajectory of cognitive decline.
Wed Sep 29 00:00:00 UTC 2021
Non-microtubule tubulin-based backbone and subordinate components of postsynaptic density lattices.
Life science alliance
Suzuki T,Terada N,Higashiyama S,Kametani K,Shirai Y,Honda M,Kai T,Li W,Tabuchi K
MA1-045 was used in Immunohistochemistry to suggest that tubulin is a key component constructing the backbone and that the associated components are essential for the versatile functions of the PSD.
Thu Jul 01 00:00:00 UTC 2021
Neuronal control of maternal provisioning in response to social cues.
Science advances
Wasson JA,Harris G,Keppler-Ross S,Brock TJ,Dar AR,Butcher RA,Fischer SEJ,Kagias K,Clardy J,Zhang Y,Mango SE
MA1-045 was used in Immunohistochemistry to suggest that loss of social cues in the parental environment represents an adverse environment that stimulates stress responses across generations.
Sun Aug 01 00:00:00 UTC 2021
The ephrin receptor EphB2 regulates the connectivity and activity of enteric neurons.
The Journal of biological chemistry
Bodin R,Paillé V,Oullier T,Durand T,Aubert P,Le Berre-Scoul C,Hulin P,Neunlist M,Cissé M
MA1-045 was used in Flow Cytometry, Immunocytochemistry, Immunoprecipitation, Western Blot, Immunohistochemistry to identify a critical role for EphB2 in the ENS and reveal a unique EphB2-mediated molecular program of synapse regulation in enteric neurons.
Mon Nov 01 00:00:00 UTC 2021
Cellular expression and subcellular localization of diacylglycerol kinase γ in rat brain.
Biomedical research (Tokyo, Japan)
Hozumi Y,Nakano T,Goto K
MA1-045 was used in Western Blot to investigate the cellular expression and subcellular localization of diacylglycerol kinase in rat brain.
Mon Nov 01 00:00:00 UTC 2021
Prediction and verification of the AD-FTLD common pathomechanism based on dynamic molecular network analysis.
Communications biology
Jin M,Jin X,Homma H,Fujita K,Tanaka H,Murayama S,Akatsu H,Tagawa K,Okazawa H
MA1-045 was used in Immunohistochemistry to reveal the common core pathological network across FTLD and AD, which is shared by mouse models and human postmortem brains.
Thu Aug 12 00:00:00 UTC 2021
Molecular motor protein KIF5C mediates structural plasticity and long-term memory by constraining local translation.
Cell reports
Swarnkar S,Avchalumov Y,Espadas I,Grinman E,Liu XA,Raveendra BL,Zucca A,Mediouni S,Sadhu A,Valente S,Page D,Miller K,Puthanveettil SV
MA1-045 was used in Flow Cytometry, Immunocytochemistry, Immunoprecipitation, Western Blot to explore the roles of KIF5C and KIF3A, two members of kinesin superfamily of molecular motors (Kifs), and find that loss of function of either kinesin decreases dendritic arborization and spine density whereas gain of function of KIF5C enhances it.
Tue Jul 13 00:00:00 UTC 2021
Endoplasmic reticulum acetyltransferases Atase1 and Atase2 differentially regulate reticulophagy, macroautophagy and cellular acetyl-CoA metabolism.
Communications biology
Rigby MJ,Lawton AJ,Kaur G,Banduseela VC,Kamm WE,Lakkaraju A,Denu JM,Puglielli L
MA1-045 was used in Immunohistochemistry to support a divergent role of Atase1 and Atase2 in cellular biology, emphasizing ATase1 as a valid translational target for diseases characterized by toxic protein aggregation in the secretory pathway.
Mon Apr 12 00:00:00 UTC 2021
Hippocampal neurons isolated from rats subjected to the valproic acid model mimic in vivo synaptic pattern: evidence of neuronal priming during early development in autism spectrum disorders.
Molecular autism
Traetta ME,Codagnone MG,Uccelli NA,Ramos AJ,Zárate S,Reinés A
MA1-045 was used in Western Blotting to suggest microglial role is not determinant for developing neuronal alterations or counteracting neuronal outcome in the hippocampus and highlights the crucial role of hippocampal neurons and structural plasticity in the establishment of the synaptic alterations in the VPA rat model.
Sat Mar 06 00:00:00 UTC 2021
Acyl-CoA synthetase 6 is required for brain docosahexaenoic acid retention and neuroprotection during aging.
JCI insight
Fernandez RF,Pereyra AS,Diaz V,Wilson ES,Litwa KA,Martínez-Gardeazabal J,Jackson SN,Brenna JT,Hermann BP,Eells JB,Ellis JM
MA1-045 was used in Western Blot to suggest that ACSL6 promotes membrane DHA enrichment in neurons, but not in astrocytes, and is important for neuronal DHA levels across the life span.
Tue Jun 08 00:00:00 UTC 2021
Development of Peptide-Based PDZ Domain Inhibitors.
Methods in molecular biology (Clifton, N.J.)
Essig DJ,Balboa JR,Strømgaard K
MA1-045 was used in Pull-Down Assay to ocus on the discovery of peptide-based drugs targeting PSD-95, using AVLX-144 as an example, from the synthesis, over binding assays to its target, to further in vitro experiments based on the development of AVLX-144, a potential stroke treatment, which is planned to enter clinical trials in 2020.
Thu Jun 17 00:00:00 UTC 2021
Endosomal traffic and glutamate synapse activity are increased in VPS35 D620N mutant knock-in mouse neurons, and resistant to LRRK2 kinase inhibition.
Molecular brain
Kadgien CA,Kamesh A,Milnerwood AJ
MA1-045 was used in Immunocytochemistry to demonstrate the VPS35 mutation has effects that are independent of ongoing LRRK2 kinase activity, and that LRRK2 kinase inhibition alters basal physiology of glutamate synapses in vitro.
Thu Sep 16 00:00:00 UTC 2021
Up-regulation of the p75 neurotrophin receptor is an essential mechanism for HIV-gp120 mediated synaptic loss in the striatum.
Brain, behavior, and immunity
Speidell A,Asuni GP,Wakulski R,Mocchetti I
MA1-045 was used in Western Blot to indicate that p75NTR could be a key player in HIV-mediated synaptic simplification in the striatum.
Thu Oct 01 00:00:00 UTC 2020
Rescuing Over-activated Microglia Restores Cognitive Performance in Juvenile Animals of the Dp(16) Mouse Model of Down Syndrome.
Neuron
Pinto B,Morelli G,Rastogi M,Savardi A,Fumagalli A,Petretto A,Bartolucci M,Varea E,Catelani T,Contestabile A,Perlini LE,Cancedda L
MA1-045 was used in Immunohistochemistry to study the roles of microglia in cognitive deficits in Dp(16)-mouse.
Wed Dec 09 00:00:00 UTC 2020
Full recovery of the Alzheimer's disease phenotype by gain of function of vacuolar protein sorting 35.
Molecular psychiatry
Li JG,Chiu J,Praticò D
MA1-045 was used in Western Blotting to demonstrate that VPS35 is directly involved in the development of Alzheimer's disease-like phenotype.
Thu Oct 01 00:00:00 UTC 2020
The green tea polyphenol epigallocatechin-3-gallate (EGCG) restores CDKL5-dependent synaptic defects in vitro and in vivo.
Neurobiology of disease
Trovò L,Fuchs C,De Rosa R,Barbiero I,Tramarin M,Ciani E,Rusconi L,Kilstrup-Nielsen C
MA1-045 was used in Immunohistochemistry-immunofluorescence to demonstrate that EGCG treatment efficiently restores defects in dendritic and synaptic development of Cdkl5-KO hippocampal neurons.
Fri May 01 00:00:00 UTC 2020
The green tea polyphenol epigallocatechin-3-gallate (EGCG) restores CDKL5-dependent synaptic defects in vitro and in vivo.
Neurobiology of disease
Trovò L,Fuchs C,De Rosa R,Barbiero I,Tramarin M,Ciani E,Rusconi L,Kilstrup-Nielsen C
MA1-045 was used in Immunohistochemistry-immunofluorescence to demonstrate that EGCG treatment efficiently restores defects in dendritic and synaptic development of Cdkl5-KO hippocampal neurons.
Fri May 01 00:00:00 UTC 2020
Astrocytic Ephrin-B1 Controls Excitatory-Inhibitory Balance in Developing Hippocampus.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Nguyen AQ,Sutley S,Koeppen J,Mina K,Woodruff S,Hanna S,Vengala A,Hickmott PW,Obenaus A,Ethell IM
MA1-045 was used in Immunohistochemistry to examine whether the loss or overexpression of the membrane-bound ephrin-B1 in astrocytes during postnatal day 14-28 period would affect synapse formation and maturation in the developing hippocampus.
Wed Sep 02 00:00:00 UTC 2020
Depression-like behaviors induced by defective PTPRT activity through dysregulated synaptic functions and neurogenesis.
Journal of cell science
Lim SH,Shin S,Kim MH,Kim EC,Lee DY,Moon J,Park HY,Ryu YK,Kang YM,Kang YJ,Kim TH,Lee NY,Kim NS,Yu DY,Shim I,Gondo Y,Satake M,Kim E,Kim KS,Min SS,Lee JR
MA1-045 was used in Immunocytochemistry to show that the physiological roles of PTPRT in hippocampal neurogenesis, as well as synaptic functions, are involved in the pathogenesis of depressive disorder.
Wed Oct 21 00:00:00 UTC 2020
Astrocytic Ephrin-B1 Controls Synapse Formation in the Hippocampus During Learning and Memory.
Frontiers in synaptic neuroscience
Nguyen AQ,Koeppen J,Woodruff S,Mina K,Figueroa Z,Ethell IM
MA1-045 was used in Immunohistochemistry to understand the mechanism by which astrocytic ephrin-B1 influences learning; specifically, learning-induced remodeling of synapses and dendritic spines in CA1 hippocampus using fear-conditioning paradigm.
Mon Sep 28 00:00:00 UTC 2020
Cyfip1 Regulates SynGAP1 at Hippocampal Synapses.
Frontiers in synaptic neuroscience
Sahasrabudhe A,Begum F,Guevara CA,Morrison C,Hsiao K,Kezunovic N,Bozdagi-Gunal O,Benson DL
MA1-045 was used in Western Blotting to examine how Cyfip1 haploinsufficiency impacts SynGAP1 levels and localization, as well as potential sites for mechanistic interaction in mouse hippocampus.
Wed Feb 24 00:00:00 UTC 2021
Elevated protein synthesis in microglia causes autism-like synaptic and behavioral aberrations.
Nature communications
Xu ZX,Kim GH,Tan JW,Riso AE,Sun Y,Xu EY,Liao GY,Xu H,Lee SH,Do NY,Lee CH,Clipperton-Allen AE,Kwon S,Page DT,Lee KJ,Xu B
MA1-045 was used in Western Blotting to propose that functional perturbation of male microglia is an important cause for sex-biased autism spectrum disorders (ASD).
Tue Apr 14 00:00:00 UTC 2020
SCH23390 Reduces Methamphetamine Self-Administration and Prevents Methamphetamine-Induced Striatal LTD.
International journal of molecular sciences
Avchalumov Y,Trenet W,Piña-Crespo J,Mandyam C
MA1-045 was used in Western Blotting to study the role of dorsal striatal dopamine D1-like receptors (D1Rs) in the reinforcing properties of methamphetamine under extended-access conditions.
Sat Sep 05 00:00:00 UTC 2020
Neuronal megalin mediates synaptic plasticity-a novel mechanism underlying intellectual disabilities in megalin gene pathologies.
Brain communications
Gomes JR,Lobo A,Nogueira R,Terceiro AF,Costelha S,Lopes IM,Magalhães A,Summavielle T,Saraiva MJ
MA1-045 was used in Western Blot to unveil a complete novel role of megalin in the physiological neuronal activity, mainly in synaptic plasticity with impact in learning and memory.
Tue Nov 24 00:00:00 UTC 2020
Oligodendroglial glycolytic stress triggers inflammasome activation and neuropathology in Alzheimer's disease.
Science advances
Zhang X,Wang R,Hu D,Sun X,Fujioka H,Lundberg K,Chan ER,Wang Q,Xu R,Flanagan ME,Pieper AA,Qi X
MA1-045 was used in Immunocytochemistry-Immunofluorescence to find that mature OLs in both AD patients and an AD mouse model undergo NLR family pyrin domain containing 3 (NLRP3)-dependent Gasdermin D-associated inflammatory injury, concomitant with demyelination and axonal degeneration.
Tue Dec 01 00:00:00 UTC 2020
PKA and Ube3a regulate SK2 channel trafficking to promote synaptic plasticity in hippocampus: Implications for Angelman Syndrome.
Scientific reports
Sun J,Liu Y,Zhu G,Cato C,Hao X,Qian L,Lin W,Adhikari R,Luo Y,Baudry M,Bi X
MA1-045 was used in Immunocytochemistry to report that PKA activation restores theta burst stimulation (TBS)-induced long-term potentiation (LTP) in hippocampal slices from AS mice by enhancing SK2 internalization.
Wed Jun 17 00:00:00 UTC 2020
Opposite Control of Excitatory and Inhibitory Synapse Formation by Slitrk2 and Slitrk5 on Dopamine Neurons Modulates Hyperactivity Behavior.
Cell reports
Salesse C,Charest J,Doucet-Beaupré H,Castonguay AM,Labrecque S,De Koninck P,Lévesque M
MA1-045 was used in Immunocytochemistry to show that alterations in developing dopaminergic circuits strongly impact locomotor activity, shedding light on mechanisms causing hyperactivity behaviors.
Tue Feb 18 00:00:00 UTC 2020
Distinct Pathogenic Genes Causing Intellectual Disability and Autism Exhibit a Common Neuronal Network Hyperactivity Phenotype.
Cell reports
Frega M,Selten M,Mossink B,Keller JM,Linda K,Moerschen R,Qu J,Koerner P,Jansen S,Oudakker A,Kleefstra T,van Bokhoven H,Zhou H,Schubert D,Nadif Kasri N
MA1-045 was used in Immunocytochemistry-immunoflourescence to investigate if Kleefstra syndrome spectrum genes mainly converge at the level of neuronal network communication.
Tue Jan 07 00:00:00 UTC 2020
Synaptic actin stabilization protein loss in Down syndrome and Alzheimer disease.
Brain pathology (Zurich, Switzerland)
Lauterborn JC,Cox CD,Chan SW,Vanderklish PW,Lynch G,Gall CM
MA1-045 was used in Immunohistochemistry to demonstrate marked synaptic disturbances in two actin regulatory proteins in adult DS and AD brains, with greater effects in individuals with AD alone.
Sun Mar 01 00:00:00 UTC 2020
Vangl2 in the Dentate Network Modulates Pattern Separation and Pattern Completion.
Cell reports
Robert BJA,Moreau MM,Dos Santos Carvalho S,Barthet G,Racca C,Bhouri M,Quiedeville A,Garret M,Atchama B,Al Abed AS,Guette C,Henderson DJ,Desmedt A,Mulle C,Marighetto A,Montcouquiol M,Sans N
MA1-045 was used in Immunocytochemistry to show that Vangl2 exerts a bimodal regulation on young and mature GCs, and its disruption leads to an imbalance in hippocampus-dependent pattern completion and separation processes.
Tue Jun 09 00:00:00 UTC 2020
Molecular Motor KIF3B Acts as a Key Regulator of Dendritic Architecture in Cortical Neurons.
Frontiers in cellular neuroscience
Joseph NF,Grinman E,Swarnkar S,Puthanveettil SV
MA1-045 was used in Immunocytochemistry to suggest that KIF3B is a key determinant of cortical neuron morphology and that it functions as an inhibitory constraint on structural plasticity, further illuminating the significance of mitotic KIFs in post-mitotic neurons.
Wed Nov 18 00:00:00 UTC 2020
Ameliorative role of antioxidant supplementation on sodium-arsenite induced adverse effects on the developing rat cerebellum.
Journal of Ayurveda and integrative medicine
Kaushal P,Kumar P,Dhar P
MA1-045 was used in Immunohistochemistry to study the effect of two antioxidants, alpha lipoic acid and curcumin, in developing the cerebellum of rats exposed to arsenic during postnatal period.
Fri Jan 01 00:00:00 UTC 2021
NMDAR Antibodies Alter Dopamine Receptors and Cause Psychotic Behavior in Mice.
Annals of neurology
Carceles-Cordon M,Mannara F,Aguilar E,Castellanos A,Planagumà J,Dalmau J
MA1-045 was used in Immunohistochemistry to determine the effect of NMDAR antibodies on mice.
Tue Sep 01 00:00:00 UTC 2020
A pharmacological chaperone improves memory by reducing Aβ and tau neuropathology in a mouse model with plaques and tangles.
Molecular neurodegeneration
Li JG,Chiu J,Ramanjulu M,Blass BE,Praticò D
MA1-045 was used in Western Blotting to demonstrate that vacuolar protein sorting 35 genetic manipulation modulates the phenotype of mouse models of Alzheimer's disease.
Wed Jan 22 00:00:00 UTC 2020
High-Resolution Three-Dimensional Imaging of Individual Astrocytes Using Confocal Microscopy.
Current protocols in neuroscience
Testen A,Kim R,Reissner KJ
MA1-045 was used in Immunohistochemistry to describe a method utilizing a commercially available and validated, genetically encoded membrane-associated fluorescent marker of astrocytes, AAV5-GfaABC1D-Lck-GFP.
Sun Mar 01 00:00:00 UTC 2020
Synaptic RTP801 contributes to motor-learning dysfunction in Huntington's disease.
Cell death & disease
Martín-Flores N,Pérez-Sisqués L,Creus-Muncunill J,Masana M,Ginés S,Alberch J,Pérez-Navarro E,Malagelada C
MA1-045 was used in Western Blotting to indicate that mhtt-induced RTP801 mediates motor dysfunction in a Huntington's disease murine model.
Thu Jul 30 00:00:00 UTC 2020
Hyperactive and impulsive behaviors of LMTK1 knockout mice.
Scientific reports
Takahashi M,Sugiyama A,Wei R,Kobayashi S,Fukuda K,Nishino H,Takahashi R,Tsutsumi K,Kita I,Ando K,Manabe T,Kamiguchi H,Tomomura M,Hisanaga SI
MA1-045 was used in Immunocytochemistry-immunoflourescence to examine the brain structures and behaviors of Lemur tail kinase 1 knockout (KO) mice.
Tue Sep 22 00:00:00 UTC 2020
Targeting PPARα in the rat valproic acid model of autism: focus on social motivational impairment and sex-related differences.
Molecular autism
Scheggi S,Guzzi F,Braccagni G,De Montis MG,Parenti M,Gambarana C
MA1-045 was used in Western Blotting to highlight sex-related differences in the expression of Austism Spectrum Disorder like symptoms and their differential responses to fenofibrate treatment.
Mon Jul 27 00:00:00 UTC 2020
Preservation of global synaptic excitatory to inhibitory ratio during long postmortem intervals.
Scientific reports
Scaduto P,Sequeira A,Vawter MP,Bunney W,Limon A
MA1-045 was used in Western Blot to demonstrate that near-simultaneous recording of microtransplanted synaptic receptors after simulated morgue conditions allows the determination of the postsynaptic E/I ratio for at least 120 h after death.
Mon May 25 00:00:00 UTC 2020
Preservation of global synaptic excitatory to inhibitory ratio during long postmortem intervals.
Scientific reports
Scaduto P,Sequeira A,Vawter MP,Bunney W,Limon A
MA1-045 was used in Western Blot to demonstrate that near-simultaneous recording of microtransplanted synaptic receptors after simulated morgue conditions allows the determination of the postsynaptic E/I ratio for at least 120 h after death.
Mon May 25 00:00:00 UTC 2020
Microglia Dysfunction Caused by the Loss of Rhoa Disrupts Neuronal Physiology and Leads to Neurodegeneration.
Cell reports
Socodato R,Portugal CC,Canedo T,Rodrigues A,Almeida TO,Henriques JF,Vaz SH,Magalhães J,Silva CM,Baptista FI,Alves RL,Coelho-Santos V,Silva AP,Paes-de-Carvalho R,Magalhães A,Brakebusch C,Sebastião AM,Summavielle T,Ambrósio AF,Relvas JB
MA1-045 was used in Flow Cytometry to demonstrate the role of small GTPase Rhoa in microglia activation.
Tue Jun 23 00:00:00 UTC 2020
Identification of Neuronal Pentraxins as Synaptic Binding Partners of C1q and the Involvement of NP1 in Synaptic Pruning in Adult Mice.
Frontiers in immunology
Kovács RÁ,Vadászi H,Bulyáki É,Török G,Tóth V,Mátyás D,Kun J,Hunyadi-Gulyás É,Fedor FZ,Csincsi Á,Medzihradszky K,Homolya L,Juhász G,Kékesi KA,Józsi M,Györffy BA,Kardos J
MA1-045 was used in Western Blot to indicate that NPs play a regulatory role in the synaptic function of C1q.
Wed Jun 16 00:00:00 UTC 2021
Synaptotagmin-3 drives AMPA receptor endocytosis, depression of synapse strength, and forgetting.
Science (New York, N.Y.)
Awasthi A,Ramachandran B,Ahmed S,Benito E,Shinoda Y,Nitzan N,Heukamp A,Rannio S,Martens H,Barth J,Burk K,Wang YT,Fischer A,Dean C
MA1-045 was used in Western Blotting to discover that synaptotagmin-3 localises to postsynaptic endocytic zones and removes AMPA receptors from synaptic plasma membranes in response to stimulation.
Fri Jan 04 00:00:00 UTC 2019
Synaptotagmin-3 drives AMPA receptor endocytosis, depression of synapse strength, and forgetting.
Science (New York, N.Y.)
Awasthi A,Ramachandran B,Ahmed S,Benito E,Shinoda Y,Nitzan N,Heukamp A,Rannio S,Martens H,Barth J,Burk K,Wang YT,Fischer A,Dean C
MA1-045 was used in Western Blotting to discover that synaptotagmin-3 localises to postsynaptic endocytic zones and removes AMPA receptors from synaptic plasma membranes in response to stimulation.
Fri Jan 04 00:00:00 UTC 2019
Early-life exposure to high-fat diet influences brain health in aging mice.
Aging cell
Di Meco A,Praticò D
MA1-045 was used in Western Blotting to investigate the effect that maternal high-fat diet during gestation has on brain health of the offspring later in life.
Sun Dec 01 00:00:00 UTC 2019
Early-life exposure to high-fat diet influences brain health in aging mice.
Aging cell
Di Meco A,Praticò D
MA1-045 was used in Western Blotting to investigate the effect that maternal high-fat diet during gestation has on brain health of the offspring later in life.
Sun Dec 01 00:00:00 UTC 2019
Presynaptic α2δ-2 Calcium Channel Subunits Regulate Postsynaptic GABAA Receptor Abundance and Axonal Wiring.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Geisler S,Schöpf CL,Stanika R,Kalb M,Campiglio M,Repetto D,Traxler L,Missler M,Obermair GJ
MA1-045 was used in Immunocytochemistry-immunoflourescence to study the specific functions of the individual α2δ Calcium channel isoforms and their role in GABAergic synapses.
Wed Apr 03 00:00:00 UTC 2019
The LMTK1-TBC1D9B-Rab11A Cascade Regulates Dendritic Spine Formation via Endosome Trafficking.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Nishino H,Saito T,Wei R,Takano T,Tsutsumi K,Taniguchi M,Ando K,Tomomura M,Fukuda M,Hisanaga SI
MA1-045 was used in Immunohistochemistry-immunofluorescence to investigate the role of LMTK1 in spine formation.
Wed Nov 27 00:00:00 UTC 2019
Phosphorylated CRMP2 Regulates Spinal Nociceptive Neurotransmission.
Molecular neurobiology
Yu J,Moutal A,Dorame A,Bellampalli SS,Chefdeville A,Kanazawa I,Pham NYN,Park KD,Weimer JM,Khanna R
MA1-045 was used in Western Blot to show collapsin response mediator protein 2 (CRMP2) may play a role in regulating pathological pain by regulating presynaptic excitatory neurotransmission.
Mon Jul 01 00:00:00 UTC 2019
Uncovering the Functional Link Between SHANK3 Deletions and Deficiency in Neurodevelopment Using iPSC-Derived Human Neurons.
Frontiers in neuroanatomy
Huang G,Chen S,Chen X,Zheng J,Xu Z,Doostparast Torshizi A,Gong S,Chen Q,Ma X,Yu J,Zhou L,Qiu S,Wang K,Shi L
MA1-045 was used in Immunocytochemistry-immunoflourescence to study the effects of SHANK3 loss of function mutations on neurodevelopment.
Thu Oct 01 00:00:00 UTC 2020
Long-Term Potentiation of Prelimbic Cortex Ascribed to Heat-Sensitization Responses of Moxibustion.
Evidence-based complementary and alternative medicine : eCAM
Chen R,Lyu Z,Xie D,Huang D,Chen Y,Wu C
MA1-045 was used in Immunocytochemistry to assess the effects of phosphorylation of Cofilin representing long-term potentiation in synapse of prelimbic cortex of medial prefrontal cortex in stroke rats over suspended moxibustion.
Wed Sep 30 00:00:00 UTC 2020
Autophagy protein NRBF2 has reduced expression in Alzheimer's brains and modulates memory and amyloid-beta homeostasis in mice.
Molecular neurodegeneration
Lachance V,Wang Q,Sweet E,Choi I,Cai CZ,Zhuang XX,Zhang Y,Jiang JL,Blitzer RD,Bozdagi-Gunal O,Zhang B,Lu JH,Yue Z
MA1-045 was used in Western Blotting to study NRBF2 as a therapeutic target for Alzheimer's disease for reducing cognitive decline.
Wed Nov 27 00:00:00 UTC 2019
Pannexin 1 Regulates Network Ensembles and Dendritic Spine Development in Cortical Neurons.
eNeuro
Sanchez-Arias JC,Liu M,Choi CSW,Ebert SN,Brown CE,Swayne LA
MA1-045 was used in Western Blotting to study the underlying molecular mechanisms that regulate dendritic spine development in cortical neurons.
Mon Mar 30 00:00:00 UTC 2020
Neuronal network dysfunction in a model for Kleefstra syndrome mediated by enhanced NMDAR signaling.
Nature communications
Frega M,Linda K,Keller JM,Gümüş-Akay G,Mossink B,van Rhijn JR,Negwer M,Klein Gunnewiek T,Foreman K,Kompier N,Schoenmaker C,van den Akker W,van der Werf I,Oudakker A,Zhou H,Kleefstra T,Schubert D,van Bokhoven H,Nadif Kasri N
MA1-045 was used in Immunocytochemistry to provide a direct link between EHMT1 deficiency and NMDAR hyperfunction in human neurons within a model of Kleefstra syndrome.
Wed Oct 30 00:00:00 UTC 2019
Endothelium-Derived Semaphorin 3G Regulates Hippocampal Synaptic Structure and Plasticity via Neuropilin-2/PlexinA4.
Neuron
Tan C,Lu NN,Wang CK,Chen DY,Sun NH,Lyu H,Körbelin J,Shi WX,Fukunaga K,Lu YM,Han F
MA1-045 was used in Immunohistochemistry to highlight the role of vascular endothelial cells in regulating cognitive function through intercellular communication with neurons in the hippocampus.
Wed Mar 06 00:00:00 UTC 2019
Abnormal mGluR-mediated synaptic plasticity and autism-like behaviours in Gprasp2 mutant mice.
Nature communications
Edfawy M,Guedes JR,Pereira MI,Laranjo M,Carvalho MJ,Gao X,Ferreira PA,Caldeira G,Franco LO,Wang D,Cardoso AL,Feng G,Carvalho AL,Peça J
MA1-045 was used in Immunocytochemistry-immunoflourescence to investigate the physiological role of Gprasp2.
Fri Mar 29 00:00:00 UTC 2019
Pharmacological activation of the nuclear receptor REV-ERB reverses cognitive deficits and reduces amyloid-β burden in a mouse model of Alzheimer's disease.
PloS one
Roby DA,Ruiz F,Kermath BA,Voorhees JR,Niehoff M,Zhang J,Morley JE,Musiek ES,Farr SA,Burris TP
MA1-045 was used in Western Blotting to study the effect of enhanced REV-ERB activity on cognitive function in Alzheimer's disease mouse models.
Fri Dec 20 00:00:00 UTC 2019
Region-Specific Differences in Morphometric Features and Synaptic Colocalization of Astrocytes During Development.
Neuroscience
Testen A,Ali M,Sexton HG,Hodges S,Dubester K,Reissner KJ,Swartzwelder HS,Risher ML
MA1-045 was used in Immunohistochemistry (PFA fixed) to determine whether mPFC and dHipp astrocytes have temporally distinct maturation trajectories.
Thu Feb 21 00:00:00 UTC 2019
Caspase-2 promotes AMPA receptor internalization and cognitive flexibility via mTORC2-AKT-GSK3β signaling.
Nature communications
Xu ZX,Tan JW,Xu H,Hill CJ,Ostrovskaya O,Martemyanov KA,Xu B
MA1-045 was used in Western Blotting to determine the critical role of caspase-2 in synaptic plasticity and cognition, and uncover a caspase-2-mTORC2-Akt-GSK3Β signaling cascade in Casp2 KO mice.
Fri Aug 09 00:00:00 UTC 2019
C9ORF72-ALS/FTD-associated poly(GR) binds Atp5a1 and compromises mitochondrial function in vivo.
Nature neuroscience
Choi SY,Lopez-Gonzalez R,Krishnan G,Phillips HL,Li AN,Seeley WW,Yao WD,Almeida S,Gao FB
MA1-045 was used in Western Blot to establish an inducible mouse model of poly(GR) toxicity in which (GR)80 gradually accumulates in cortical excitatory neurons.
Sat Jun 01 00:00:00 UTC 2019
Thrombospondin receptor α2δ-1 promotes synaptogenesis and spinogenesis via postsynaptic Rac1.
The Journal of cell biology
Risher WC,Kim N,Koh S,Choi JE,Mitev P,Spence EF,Pilaz LJ,Wang D,Feng G,Silver DL,Soderling SH,Yin HH,Eroglu C
MA1-045 was used in Immunocytochemistry-immunoflourescence to study the mechanism by which the thrombospondin-α2δ-1 interaction promotes synaptogenesis, and the requirement for α2δ-1 for connectivity of the developing mammalian brain.
Mon Oct 01 00:00:00 UTC 2018
Memory-Related Synaptic Plasticity Is Sexually Dimorphic in Rodent Hippocampus.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Wang W,Le AA,Hou B,Lauterborn JC,Cox CD,Levin ER,Lynch G,Gall CM
MA1-045 was used in Immunohistochemistry-immunofluorescence to study the sexual dimorphism in synaptic mechanisms of memory encoding in hippocampal field CA1.
Wed Sep 12 00:00:00 UTC 2018
Memory-Related Synaptic Plasticity Is Sexually Dimorphic in Rodent Hippocampus.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Wang W,Le AA,Hou B,Lauterborn JC,Cox CD,Levin ER,Lynch G,Gall CM
MA1-045 was used in Immunohistochemistry-immunofluorescence to study the sexual dimorphism in synaptic mechanisms of memory encoding in hippocampal field CA1.
Wed Sep 12 00:00:00 UTC 2018
Deficiency of AMPAR-Palmitoylation Aggravates Seizure Susceptibility.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Itoh M,Yamashita M,Kaneko M,Okuno H,Abe M,Yamazaki M,Natsume R,Yamada D,Kaizuka T,Suwa R,Sakimura K,Sekiguchi M,Wada K,Hoshino M,Mishina M,Hayashi T
MA1-045 was used in Western Blotting to provide insight into how predicted receptors such as AMPARs can effectively preserve network stability in the brain.
Wed Nov 21 00:00:00 UTC 2018
Functional Consequences of Synapse Remodeling Following Astrocyte-Specific Regulation of Ephrin-B1 in the Adult Hippocampus.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Koeppen J,Nguyen AQ,Nikolakopoulou AM,Garcia M,Hanna S,Woodruff S,Figueroa Z,Obenaus A,Ethell IM
MA1-045 was used in Immunohistochemistry to examine the role of astrocytic ephrin-B1 as a regulator of synaptogenesis in the murine adult hippocampus and learning behaviours.
Wed Jun 20 00:00:00 UTC 2018
Silver nanoparticles induce neurotoxicity in a human embryonic stem cell-derived neuron and astrocyte network.
Nanotoxicology
Repar N,Li H,Aguilar JS,Li QQ,Drobne D,Hong Y
MA1-045 was used in Immunocytochemistry-immunoflourescence to study the neurotoxicity that is induced by citrate-coated silver nanoparticles.
Thu Mar 01 00:00:00 UTC 2018
The antidepressant tianeptine reverts synaptic AMPA receptor defects caused by deficiency of CDKL5.
Human molecular genetics
Tramarin M,Rusconi L,Pizzamiglio L,Barbiero I,Peroni D,Scaramuzza L,Guilliams T,Cavalla D,Antonucci F,Kilstrup-Nielsen C
MA1-045 was used in Immunocytochemistry-immunoflourescence to show that Cdkl5 deficiency in primary hippocampal neurons leads to deranged expression of the alpha-amino-3-hydroxy-5-methyl-4-iso-xazole propionic acid receptors.
Fri Jun 15 00:00:00 UTC 2018
Targeting Tyro3 ameliorates a model of PGRN-mutant FTLD-TDP via tau-mediated synaptic pathology.
Nature communications
Fujita K,Chen X,Homma H,Tagawa K,Amano M,Saito A,Imoto S,Akatsu H,Hashizume Y,Kaibuchi K,Miyano S,Okazawa H
MA1-045 was used in Immunohistochemistry to suggest that targeting of early-stage and aggregation-independent tau signalling represents a promising therapeutic strategy for frontotemporal lobar degeneration.
Tue Jan 30 00:00:00 UTC 2018
UBE3A-mediated p18/LAMTOR1 ubiquitination and degradation regulate mTORC1 activity and synaptic plasticity.
eLife
Sun J,Liu Y,Jia Y,Hao X,Lin WJ,Tran J,Lynch G,Baudry M,Bi X
MA1-045 was used in Immunocytochemistry-immunoflourescence to study the effects of ubiquitin E3 ligase, UBE3A, on mechanistic target of rapamycin complex 1 signalling, and the mechanisms responsible.
Wed Jul 18 00:00:00 UTC 2018
Altered dopamine release and monoamine transporters in Vps35 p.D620N knock-in mice.
NPJ Parkinson's disease
Cataldi S,Follett J,Fox JD,Tatarnikov I,Kadgien C,Gustavsson EK,Khinda J,Milnerwood AJ,Farrer MJ
MA1-045 was used in Western Blotting to examine the effects of altered dopamine release and monoamine transporters in Vps35 p.D620N knock-in mice.
Tue Sep 29 00:00:00 UTC 2020
The Nogo Receptor Ligand LGI1 Regulates Synapse Number and Synaptic Activity in Hippocampal and Cortical Neurons.
eNeuro
Thomas RA,Gibon J,Chen CXQ,Chierzi S,Soubannier VG,Baulac S,Séguéla P,Murai K,Barker PA
MA1-045 was used in Western Blotting and ICC/IF to suggest that LGI1 enhances synapse formation in cortical and hippocampal neurons by reducing NgR1 signaling.
Fri Mar 08 00:00:00 UTC 2019
The Nogo Receptor Ligand LGI1 Regulates Synapse Number and Synaptic Activity in Hippocampal and Cortical Neurons.
eNeuro
Thomas RA,Gibon J,Chen CXQ,Chierzi S,Soubannier VG,Baulac S,Séguéla P,Murai K,Barker PA
MA1-045 was used in Western Blotting and ICC/IF to suggest that LGI1 enhances synapse formation in cortical and hippocampal neurons by reducing NgR1 signaling.
Fri Mar 08 00:00:00 UTC 2019
Selective Targeting of Neurons with Inorganic Nanoparticles: Revealing the Crucial Role of Nanoparticle Surface Charge.
ACS nano
Dante S,Petrelli A,Petrini EM,Marotta R,Maccione A,Alabastri A,Quarta A,De Donato F,Ravasenga T,Sathya A,Cingolani R,Proietti Zaccaria R,Berdondini L,Barberis A,Pellegrino T
MA1-045 was used in Immunocytochemistry-immunoflourescence to demonstrate that negatively charged nanoparticles modulate the excitability of neurons, revealing the potential use of nanoparticles for controlling neuron activity.
Tue Jul 25 00:00:00 UTC 2017
APC/CCdh1-Rock2 pathway controls dendritic integrity and memory.
Proceedings of the National Academy of Sciences of the United States of America
Bobo-Jiménez V,Delgado-Esteban M,Angibaud J,Sánchez-Morán I,de la Fuente A,Yajeya J,Nägerl UV,Castillo J,Bolaños JP,Almeida A
MA1045 was used in western blot to report that the anaphase-promoting complex/cyclosome-mediated degradation of Rock2 maintains the dendritic network, memory formation, and neuronal survival
Tue Apr 25 00:00:00 UTC 2017
Phosphoinositide-dependent enrichment of actin monomers in dendritic spines regulates synapse development and plasticity.
The Journal of cell biology
Lei W,Myers KR,Rui Y,Hladyshau S,Tsygankov D,Zheng JQ
MA1-045 was used in Immunocytochemistry-immunoflourescence to elucidate the mechanisms regulating the formation and modification of dendritic spines in the vertebrate brain.
Mon Aug 07 00:00:00 UTC 2017
Hierarchical organization and genetically separable subfamilies of PSD95 postsynaptic supercomplexes.
Journal of neurochemistry
Frank RAW,Zhu F,Komiyama NH,Grant SGN
MA1-045 was used in Immunohistochemistry and Western Blot to gain insight into the mechanisms that govern the constituents of postsynaptic supercomplexes and the diversity of synapse types.
Tue Aug 01 00:00:00 UTC 2017
Hierarchical organization and genetically separable subfamilies of PSD95 postsynaptic supercomplexes.
Journal of neurochemistry
Frank RAW,Zhu F,Komiyama NH,Grant SGN
MA1-045 was used in Immunohistochemistry and Western Blot to gain insight into the mechanisms that govern the constituents of postsynaptic supercomplexes and the diversity of synapse types.
Tue Aug 01 00:00:00 UTC 2017
Impaired GABAergic inhibition in the hippocampus of Fmr1 knockout mice.
Neuropharmacology
Sabanov V,Braat S,D'Andrea L,Willemsen R,Zeidler S,Rooms L,Bagni C,Kooy RF,Balschun D
MA1045 was used in western blot to explore the functional consequences of Fmr1 protein deletion on hippocampal GABAergic inhibition in the CA1-region of the hippocampus
Sat Apr 01 00:00:00 UTC 2017
Genetic absence of ALOX5 protects from homocysteine-induced memory impairment, tau phosphorylation and synaptic pathology.
Human molecular genetics
Li JG,Barrero C,Merali S,Praticò D
MA1-045 was used in Western Blotting to determine the role of the ALOX5 gene in the development of the neuropathological, biochemical and behavioural sequelae of increased homocysteine.
Mon May 15 00:00:00 UTC 2017
Cofilin Activation Is Temporally Associated with the Cessation of Growth in the Developing Hippocampus.
Cerebral cortex (New York, N.Y. : 1991)
Lauterborn JC,Kramár EA,Rice JD,Babayan AH,Cox CD,Karsten CA,Gall CM,Lynch G
MA1-045 was used in immunocytochemistry to investigate the temporally associated cessation of growth in the developing hippocampus by cofilin activation
Sat Apr 01 00:00:00 UTC 2017
Sex-dependent influence of chronic mild stress (CMS) on voluntary alcohol consumption; study of neurobiological consequences.
Pharmacology, biochemistry, and behavior
Marco EM,Ballesta JA,Irala C,Hernández MD,Serrano ME,Mela V,López-Gallardo M,Viveros MP
MA1045 was used in western blot to study voluntary alcohol consumption after chronic mild stress in Wistar rats
Sun Jan 01 00:00:00 UTC 2017
Temporal regulation of epithelium formation mediated by FoxA, MKLP1, MgcRacGAP, and PAR-6.
Molecular biology of the cell
Von Stetina SE,Liang J,Marnellos G,Mango SE
MA1-045 was used in Immunocytochemistry to elucidate the temporal regulators of epithelium formation.
Sat Jul 15 00:00:00 UTC 2017
Dynamic Arc SUMOylation and Selective Interaction with F-Actin-Binding Protein Drebrin A in LTP Consolidation In Vivo.
Frontiers in synaptic neuroscience
Nair RR,Patil S,Tiron A,Kanhema T,Panja D,Schiro L,Parobczak K,Wilczynski G,Bramham CR
MA1-045 was used in Western Blot to study the mechanisms controlling activity-regulatedcytoskeleton-associated protein function.
Tue Sep 29 00:00:00 UTC 2020
Experiential learning in rodents: past experience enables rapid learning and localized encoding in hippocampus.
Learning & memory (Cold Spring Harbor, N.Y.)
Cox CD,Palmer LC,Pham DT,Trieu BH,Gall CM,Lynch G
MA1-045 was used in Immunohistochemistry-immunofluorescence to study how the transfer of experience profoundly affects the manner in which the hippocampus encodes complex information.
Wed Nov 01 00:00:00 UTC 2017
Neuropeptide VGF Promotes Maturation of Hippocampal Dendrites That Is Reduced by Single Nucleotide Polymorphisms.
International journal of molecular sciences
Behnke J,Cheedalla A,Bhatt V,Bhat M,Teng S,Palmieri A,Windon CC,Thakker-Varia S,Alder J
MA1045 was used in immunocytochemistry and western blot to propose that VGF enhances dendritic maturation and examine the effects of different VGF mutations
Sat Mar 11 00:00:00 UTC 2017
Transient oxytocin signaling primes the development and function of excitatory hippocampal neurons.
eLife
Ripamonti S,Ambrozkiewicz MC,Guzzi F,Gravati M,Biella G,Bormuth I,Hammer M,Tuffy LP,Sigler A,Kawabe H,Nishimori K,Toselli M,Brose N,Parenti M,Rhee J
MA1045 was used in immunocytochemistry to demonstrate that oxytocin controls the development and activation of hippocampal excitatory neurons
Thu Feb 23 00:00:00 UTC 2017
Continued 26S proteasome dysfunction in mouse brain cortical neurons impairs autophagy and the Keap1-Nrf2 oxidative defence pathway.
Cell death & disease
Ugun-Klusek A,Tatham MH,Elkharaz J,Constantin-Teodosiu D,Lawler K,Mohamed H,Paine SM,Anderson G,John Mayer R,Lowe J,Ellen Billett E,Bedford L
MA1045 was used in western blot to find that continued 26S proteasome dysfunction in mouse brain cortical neurons causes paranuclear accumulation of fragmented dysfunctional mitochondria, associated with earlier recruitment of Parkin and lysine 48-linked ubiquitination of mitochond
Thu Jan 05 00:00:00 UTC 2017
Impaired Dendritic Development and Memory in Sorbs2 Knock-Out Mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Zhang Q,Gao X,Li C,Feliciano C,Wang D,Zhou D,Mei Y,Monteiro P,Anand M,Itohara S,Dong X,Fu Z,Feng G
MA1-045 was used in immunocytochemistry to assess the impaired memory and dendritic development in Sorbs2 knock-out mice
Wed Feb 17 00:00:00 UTC 2016
Neuronal Dystroglycan Is Necessary for Formation and Maintenance of Functional CCK-Positive Basket Cell Terminals on Pyramidal Cells.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Früh S,Romanos J,Panzanelli P,Bürgisser D,Tyagarajan SK,Campbell KP,Santello M,Fritschy JM
MA1-045 was used in Immunohistochemistry to demonstrate that dystroglycan has a function at postsynaptic sites restricted to a subset of GABAergic interneurons.
Wed Oct 05 00:00:00 UTC 2016
DISC1, astrocytes and neuronal maturation: a possible mechanistic link with implications for mental disorders.
Journal of neurochemistry
Xia M,Zhu S,Shevelkin A,Ross CA,Pletnikov M
MA1-045 was used in immunocytochemistry to determine a link with implications for mental disorders via DISC1 and astrocytes and neuronal maturation
Mon Aug 01 00:00:00 UTC 2016
Ontogenic Profile and Synaptic Distribution of GluN3 Proteins in the Rat Brain and Hippocampal Neurons.
Neurochemical research
Wee KS,Tan FC,Cheong YP,Khanna S,Low CM
MA1-045 was used in immunoprecipitation and western blot to survey rat brain and hippocampal neurons by looking at the ontogenic profile and synaptic distribution of GluN3 proteins
Mon Feb 01 00:00:00 UTC 2016
Silver nanoparticles exhibit coating and dose-dependent neurotoxicity in glutamatergic neurons derived from human embryonic stem cells.
Neurotoxicology
Begum AN,Aguilar JS,Elias L,Hong Y
MA1045 was used in immunocytochemistry to investigate 20nm citrate-coated and polyvinylpyrrolidone-coated silver nanoparticle-induced neurotoxicity
Thu Dec 01 00:00:00 UTC 2016
Monitoring mRNA Translation in Neuronal Processes Using Fluorescent Non-Canonical Amino Acid Tagging.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
Kos A,Wanke KA,Gioio A,Martens GJ,Kaplan BB,Aschrafi A
MA1-045 was used in immunocytochemistry to utilize fluorescent non-canonical amino acid tagging to monitor mRNA translation in neuronal processes
Sun May 01 00:00:00 UTC 2016
A Primary Cortical Input to Hippocampus Expresses a Pathway-Specific and Endocannabinoid-Dependent Form of Long-Term Potentiation.
eNeuro
Wang W,Trieu BH,Palmer LC,Jia Y,Pham DT,Jung KM,Karsten CA,Merrill CB,Mackie K,Gall CM,Piomelli D,Lynch G
MA1-045 was used in Immunofluorescence in immunohistochemistry on frozen tissues to indicate that the encoding of information carried by a principal hippocampal afferent involves an unusual, regionally differentiated form of plasticity.
Wed Oct 25 00:00:00 UTC 2017
NMDA receptors are selectively partitioned into complexes and supercomplexes during synapse maturation.
Nature communications
Frank RA,Komiyama NH,Ryan TJ,Zhu F,O'Dell TJ,Grant SG
MA1-045 was used in western blot to analyze selective partitioning into complexes and supercomplexes during synapse maturation by NMDA receptors
Wed Apr 27 00:00:00 UTC 2016
Transplanted neurons integrate into adult retinas and respond to light.
Nature communications
Venugopalan P,Wang Y,Nguyen T,Huang A,Muller KJ,Goldberg JL
MA1-045 was used in immunohistochemistry - frozen section to learn about the integration into adult retinas and their response to light after neurons are transplanted
Thu Feb 04 00:00:00 UTC 2016
Mutations in NONO lead to syndromic intellectual disability and inhibitory synaptic defects.
Nature neuroscience
Mircsof D,Langouët M,Rio M,Moutton S,Siquier-Pernet K,Bole-Feysot C,Cagnard N,Nitschke P,Gaspar L,Žnidarič M,Alibeu O,Fritz AK,Wolfer DP,Schröter A,Bosshard G,Rudin M,Koester C,Crestani F,Seebeck P,Boddaert N,Prescott K,Hines R,Moss SJ,Fritschy JM,Munnich A,Amiel J,Brown SA,Tyagarajan SK,Colleaux L
MA1-045 was used in western blot to characterize NONO-deficient mice
Tue Dec 01 00:00:00 UTC 2015
Cellular plasticity induced by anti-α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor encephalitis antibodies.
Annals of neurology
Peng X,Hughes EG,Moscato EH,Parsons TD,Dalmau J,Balice-Gordon RJ
MA1-045 was used in immunocytochemistry to study the role of anti-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) in encephalitis
Sun Mar 01 00:00:00 UTC 2015
PSD-Zip70 Deficiency Causes Prefrontal Hypofunction Associated with Glutamatergic Synapse Maturation Defects by Dysregulation of Rap2 Activity.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Mayanagi T,Yasuda H,Sobue K
MA1-045 was used in immunocytochemistry to study the dysregulation of Rap2 activity due to PSD-Zip70 deficiency that causes prefrontal hypofunction associated with glutamatergic synapse maturation defects
Wed Oct 21 00:00:00 UTC 2015
Activity-dependent rapid local RhoA synthesis is required for hippocampal synaptic plasticity.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Briz V,Zhu G,Wang Y,Liu Y,Avetisyan M,Bi X,Baudry M
MA1-045 was used in immunohistochemistry - frozen section to study the temporal and spatial relationship between dendritic protein synthesis and actin cytoskeleton reorganization
Wed Feb 04 00:00:00 UTC 2015
Differential regulation of two isoforms of the glial glutamate transporter EAAT2 by DLG1 and CaMKII.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Underhill SM,Wheeler DS,Amara SG
MA1-045 was used in western blot to investigate the role of the C termini on EAAT2b trafficking and surface localization
Wed Apr 01 00:00:00 UTC 2015
Different patterns of electrical activity lead to long-term potentiation by activating different intracellular pathways.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Zhu G,Liu Y,Wang Y,Bi X,Baudry M
MA1-045 was used in immunohistochemistry - frozen section to report that hippocampal CA1 pyramidal neurons respond to brief bursts of high-frequency stimulation and theta burst stimulation with long-lasting enhanced responses
Wed Jan 14 00:00:00 UTC 2015
Hypothalamic, feeding/arousal-related peptidergic projections to the paraventricular thalamic nucleus in the rat.
Brain research
Lee JS,Lee EY,Lee HS
MA1-045 was used in immunohistochemistry - frozen section to determine projection patterns of neuropeptide Y, cocaine- and amphetamine-regulated transcript, melanin-concentrating hormone, and orexin-ergic fibers in the paraventricular thalamic nucleus.
Thu Feb 19 00:00:00 UTC 2015
PAR-6, but not E-cadherin and β-integrin, is necessary for epithelial polarization in C. elegans.
Developmental biology
Von Stetina SE,Mango SE
MA1-045 was used in immunohistochemistry to test if cadherins and integrins are functionally redundant during epithelium formation.
Wed Jul 01 00:00:00 UTC 2015
GGGGCC microsatellite RNA is neuritically localized, induces branching defects, and perturbs transport granule function.
eLife
Burguete AS,Almeida S,Gao FB,Kalb R,Akins MR,Bonini NM
MA1-045 was used in immunohistochemistry to characterize GGGGCC microsatelline RNA and induction of branching defects, neuritical localization, and perturbing of transport granule function
Wed Dec 09 00:00:00 UTC 2015
Preferential loss of dorsal-hippocampus synapses underlies memory impairments provoked by short, multimodal stress.
Molecular psychiatry
Maras PM,Molet J,Chen Y,Rice C,Ji SG,Solodkin A,Baram TZ
MA1-045 was used in immunohistochemistry to study memory impairment induced by short multi-modal stress and the role of preferential dorsal hippocampal synapse loss
Tue Jul 01 00:00:00 UTC 2014
Chronic blockade of extrasynaptic NMDA receptors ameliorates synaptic dysfunction and pro-death signaling in Huntington disease transgenic mice.
Neurobiology of disease
Dau A,Gladding CM,Sepers MD,Raymond LA
MA1-045 was used in western blot to study the beneficial effects on synaptic dysfunction of chronically blocking extra-synaptic NMDA receptors in a murine transgenic model of Huntington's disease
Sat Feb 01 00:00:00 UTC 2014
Direct association of the unique C-terminal tail of transmembrane AMPA receptor regulatory protein γ-8 with calcineurin.
The FEBS journal
Itakura M,Watanabe I,Sugaya T,Takahashi M
MA1-045 was used in immunocytochemistry to study the interaction between calcineurin and TARP-gamma8
Sat Mar 01 00:00:00 UTC 2014
Coupling of serotonergic input to NMDA receptor-phosphorylation following peripheral nerve injury via rapid, synaptic up-regulation of ND2.
Experimental neurology
Aira Z,Buesa I,Rada D,Gómez-Esteban JC,Azkue JJ
MA1-045 was used in immunohistochemistry to study the role of NADH dehydrogenase subunit 2 in NMDA receptor phosphorylation-serotonergic coupling following peripheral nerve damage
Thu May 01 00:00:00 UTC 2014
Assessment of ZnT3 and PSD95 protein levels in Lewy body dementias and Alzheimer's disease: association with cognitive impairment.
Neurobiology of aging
Whitfield DR,Vallortigara J,Alghamdi A,Howlett D,Hortobágyi T,Johnson M,Attems J,Newhouse S,Ballard C,Thomas AJ,O'Brien JT,Aarsland D,Francis PT
MA1-045 was used in western blot to investigate the relationship between ZnT3 and PSD95, cognition and pathology
Mon Dec 01 00:00:00 UTC 2014
N-cadherin regulates molecular organization of excitatory and inhibitory synaptic circuits in adult hippocampus in vivo.
Hippocampus
Nikitczuk JS,Patil SB,Matikainen-Ankney BA,Scarpa J,Shapiro ML,Benson DL,Huntley GW
MA1-045 was used in western blot to study the organization of adult hippocampal excitatory and inhibitory circuits and the role played by the N-cadherin/beta-catenin complex
Fri Aug 01 00:00:00 UTC 2014
Pathological reorganization of NMDA receptors subunits and postsynaptic protein PSD-95 distribution in Alzheimer's disease.
Current Alzheimer research
Leuba G,Vernay A,Kraftsik R,Tardif E,Riederer BM,Savioz A
MA1-045 was used in immunohistochemistry to study changes in the expression of PSD-95 and the NMDA receptor in Alzheimer's disease brain
Wed Jan 01 00:00:00 UTC 2014
Early postnatal expression and localization of matrix metalloproteinases-2 and -9 during establishment of rat hippocampal synaptic circuitry.
The Journal of comparative neurology
Aujla PK,Huntley GW
MA1-045 was used in immunocytochemistry to study the expression of MMP-2 and MMP-9 in early post-natal and adult rat hippocampus and their potential role in developing synaptic circuits within the hippocampus
Tue Apr 15 00:00:00 UTC 2014
Single-cell axotomy of cultured hippocampal neurons integrated in neuronal circuits.
Nature protocols
Gomis-Rüth S,Stiess M,Wierenga CJ,Meyn L,Bradke F
MA1-045 was used in immunocytochemistry to describe a methodology for the single-cell axotomy of hippocampal neurons in culture that contain synapses
Thu May 01 00:00:00 UTC 2014
Elfn1 recruits presynaptic mGluR7 in trans and its loss results in seizures.
Nature communications
Tomioka NH,Yasuda H,Miyamoto H,Hatayama M,Morimura N,Matsumoto Y,Suzuki T,Odagawa M,Odaka YS,Iwayama Y,Won Um J,Ko J,Inoue Y,Kaneko S,Hirose S,Yamada K,Yoshikawa T,Yamakawa K,Aruga J
MA1-045 was used in Immunocytochemistry to reveal a novel mechanism for interneuron subtype-specific neural circuit establishment and define a common basis bridging neurological disorders.
Tue Jul 22 00:00:00 UTC 2014
Elfn1 recruits presynaptic mGluR7 in trans and its loss results in seizures.
Nature communications
Tomioka NH,Yasuda H,Miyamoto H,Hatayama M,Morimura N,Matsumoto Y,Suzuki T,Odagawa M,Odaka YS,Iwayama Y,Won Um J,Ko J,Inoue Y,Kaneko S,Hirose S,Yamada K,Yoshikawa T,Yamakawa K,Aruga J
MA1-045 was used in Immunocytochemistry to reveal a novel mechanism for interneuron subtype-specific neural circuit establishment and define a common basis bridging neurological disorders.
Tue Jul 22 00:00:00 UTC 2014
Proteomic analysis of glycine receptor β subunit (GlyRβ)-interacting proteins: evidence for syndapin I regulating synaptic glycine receptors.
The Journal of biological chemistry
Del Pino I,Koch D,Schemm R,Qualmann B,Betz H,Paarmann I
MA1-045 was used in immunohistochemistry to use a proteomic approach to identify proteins that interact with GluR-beta and study the potential regulatory role of syndapin I
Fri Apr 18 00:00:00 UTC 2014
Astrocyte response to motor neuron injury promotes structural synaptic plasticity via STAT3-regulated TSP-1 expression.
Nature communications
Tyzack GE,Sitnikov S,Barson D,Adams-Carr KL,Lau NK,Kwok JC,Zhao C,Franklin RJ,Karadottir RT,Fawcett JW,Lakatos A
MA1-045 was used in immunohistochemistry - frozen section to study the effect of astrocyte reactivity on neuronal integrity and synapse recovery following extracranial facial nerve transection
Fri Jul 11 00:00:00 UTC 2014
Progressive brain damage, synaptic reorganization and NMDA activation in a model of epileptogenic cortical dysplasia.
PloS one
Colciaghi F,Finardi A,Nobili P,Locatelli D,Spigolon G,Battaglia GS
MA1-045 was used in western blot to study neocortical and hippocampal changes in a rat model of epileptogenic cortical dysplasia
Wed Oct 29 00:00:00 UTC 2014
Presynaptic neurexin-3 alternative splicing trans-synaptically controls postsynaptic AMPA receptor trafficking.
Cell
Aoto J,Martinelli DC,Malenka RC,Tabuchi K,Südhof TC
MA1-045 was used in immunocytochemistry to study the modulation of post-synaptic trafficking of the AMPA receptor by a pre-synaptic splice variant of neurexin-3
Wed Jul 03 00:00:00 UTC 2013
Long-duration epilepsy affects cell morphology and glutamatergic synapses in type IIB focal cortical dysplasia.
Acta neuropathologica
Finardi A,Colciaghi F,Castana L,Locatelli D,Marras CE,Nobili P,Fratelli M,Bramerio MA,Lorusso G,Battaglia GS
MA1-045 was used in western blot to evaluate surgical samples from patients with type IIB focal cortical dysplasia in respect of cell morphology and glutamatergic synaptic signaling and the significance for epilepsy
Thu Aug 01 00:00:00 UTC 2013
Impairment of synaptic plasticity by the stress mediator CRH involves selective destruction of thin dendritic spines via RhoA signaling.
Molecular psychiatry
Chen Y,Kramár EA,Chen LY,Babayan AH,Andres AL,Gall CM,Lynch G,Baram TZ
MA1-045 was used in immunocytochemistry to study the role of RhoA signaling in the mechanism by which corticotropin-releasing hormone reduces synaptic plasticity
Mon Apr 01 00:00:00 UTC 2013
Interaction between autism-linked MDGAs and neuroligins suppresses inhibitory synapse development.
The Journal of cell biology
Pettem KL,Yokomaku D,Takahashi H,Ge Y,Craig AM
MA1-045 was used in immunohistochemistry to study the suppressive effect of MDGA-neuroligin interactions on the formation of inhibitory synapses and the significance for neurodevelopmental disorders
Mon Feb 04 00:00:00 UTC 2013
Astroglial IFITM3 mediates neuronal impairments following neonatal immune challenge in mice.
Glia
Ibi D,Nagai T,Nakajima A,Mizoguchi H,Kawase T,Tsuboi D,Kano S,Sato Y,Hayakawa M,Lange UC,Adams DJ,Surani MA,Satoh T,Sawa A,Kaibuchi K,Nabeshima T,Yamada K
MA1-045 was used in immunocytochemistry to study murine neuronal impairment induced by neonatal polyI:C immune challenge and the role played by astroglial IFITM3
Wed May 01 00:00:00 UTC 2013
Synaptic abnormalities in the infralimbic cortex of a model of congenital depression.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Seese RR,Chen LY,Cox CD,Schulz D,Babayan AH,Bunney WE,Henn FA,Gall CM,Lynch G
MA1-045 was used in immunohistochemistry to characterize the involovement of excitatory synapses in the infralimbic cortex in congenital depression
Wed Aug 14 00:00:00 UTC 2013
NMDA receptor activation and calpain contribute to disruption of dendritic spines by the stress neuropeptide CRH.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Andres AL,Regev L,Phi L,Seese RR,Chen Y,Gall CM,Baram TZ
MA1-045 was used in immunocytochemistry to study the destruction of dendritic spines by the CRH stress neuropeptide and the roles played by calpain and the NMDA receptor
Wed Oct 23 00:00:00 UTC 2013
Loss of Ahi1 affects early development by impairing BM88/Cend1-mediated neuronal differentiation.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Weng L,Lin YF,Li AL,Wang CE,Yan S,Sun M,Gaertig MA,Mitha N,Kosaka J,Wakabayashi T,Xu X,Tang B,Li S,Li XJ
MA1-045 was used in western blot to study the interaction between Ahi and Cend1 and their mechanistic role in the differentiation of neurons
Wed May 08 00:00:00 UTC 2013
Development and plasticity of outer retinal circuitry following genetic removal of horizontal cells.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Keeley PW,Luna G,Fariss RN,Skyles KA,Madsen NR,Raven MA,Poché RA,Swindell EC,Jamrich M,Oh EC,Swaroop A,Fisher SK,Reese BE
MA1-045 was used in Immunocytochemistry-immunoflourescence to demonstrate that horizontal cells do not play a critical role in directing the initial stratification of photoreceptor and bipolar processes within the outer plexiform layer.
Wed Nov 06 00:00:00 UTC 2013
Distinct roles for μ-calpain and m-calpain in synaptic NMDAR-mediated neuroprotection and extrasynaptic NMDAR-mediated neurodegeneration.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Wang Y,Briz V,Chishti A,Bi X,Baudry M
MA1-045 was used in western blot to study the distinct roles of different calpain isoforms in synaptic neuroprotection and extrasynaptic neurodegeneration mediated by the NMDA receptor
Wed Nov 27 00:00:00 UTC 2013
Endogenous cannabinoid receptor CB1 activation promotes vascular smooth-muscle cell proliferation and neointima formation.
Journal of lipid research
Molica F,Burger F,Thomas A,Staub C,Tailleux A,Staels B,Pelli G,Zimmer A,Cravatt B,Matter CM,Pacher P,Steffens S
MA1-045 was used in immunohistochemistry to study the role of CB1 receptor activation by endogenous cannabinoids in the proliferation of smooth muscle cells and neointima formation
Wed May 01 00:00:00 UTC 2013
Zinc, magnesium and NMDA receptor alterations in the hippocampus of suicide victims.
Journal of affective disorders
Sowa-Kućma M,Szewczyk B,Sadlik K,Piekoszewski W,Trela F,Opoka W,Poleszak E,Pilc A,Nowak G
MA1-045 was used in western blot to study zinc and magnesium levels and NMDA receptor subunit composition and function in hippocampal tissue from suicide victims
Sun Dec 01 00:00:00 UTC 2013
Activation of α7-containing nicotinic receptors on astrocytes triggers AMPA receptor recruitment to glutamatergic synapses.
Journal of neurochemistry
Wang X,Lippi G,Carlson DM,Berg DK
MA1-045 was used in immunohistochemistry to study AMPAR recriutment to glutamic synapses in response to activation of alpha-7-containing nicotinic acetylcholine receptors on astrocytes
Sun Dec 01 00:00:00 UTC 2013
Activity-dependent synaptic localization of processing bodies and their role in dendritic structural plasticity.
Journal of cell science
Oh JY,Kwon A,Jo A,Kim H,Goo YS,Lee JA,Kim HK
MA1-045 was used in immunohistochemistry to study processing body redistribution in response to neuronal activation and the significance for dendrite structural plasticity
Wed May 01 00:00:00 UTC 2013
Activity-dependent secretion of progranulin from synapses.
Journal of cell science
Petoukhov E,Fernando S,Mills F,Shivji F,Hunter D,Krieger C,Silverman MA,Bamji SX
MA1-045 was used in immunohistochemistry to study the role of activity-dependent synaptic secretion of progranulin in modulating the number of synapses
Sun Dec 01 00:00:00 UTC 2013
Alzheimer brain-derived amyloid β-protein impairs synaptic remodeling and memory consolidation.
Neurobiology of aging
Borlikova GG,Trejo M,Mably AJ,Mc Donald JM,Sala Frigerio C,Regan CM,Murphy KJ,Masliah E,Walsh DM
MA1-045 was used in western blot to study the effect of water-soluble beta-amyloid extracts from Alzheimer's disease brains on synaptic remodeling and memory in recipient rats
Wed May 01 00:00:00 UTC 2013
Vangl2, the planar cell polarity protein, is complexed with postsynaptic density protein PSD-95 [corrected].
FEBS letters
Yoshioka T,Hagiwara A,Hida Y,Ohtsuka T
MA1-045 was used in immunoprecipitation and western blot to study the presence of Vangl2-PSD-95 complexes in adult rat neurons
Tue May 21 00:00:00 UTC 2013
Phosphorylation of collapsin response mediator protein-2 regulates its localization and association with hippocampal cholinergic neurostimulating peptide precursor in the hippocampus.
Neuroscience letters
Mizuno M,Kato D,Kanamori T,Toyoda T,Suzuki T,Ojika K,Matsukawa N
MA1-045 was used in western blot to study the role of CRMP-2 phosphorylation in modulating its hippocampal localization and interaction with precursor-HCNP
Fri Feb 22 00:00:00 UTC 2013
Neuropeptide orphanin FQ inhibits dendritic morphogenesis through activation of RhoA.
Developmental neurobiology
Alder J,Kallman S,Palmieri A,Khadim F,Ayer JJ,Kumar S,Tsung K,Grinberg I,Thakker-Varia S
MA1-045 was used in immunocytochemistry to study the role of RhoA in the mechanism by which the neuropeptide orphanin FQ blocks dendrite morphogenesis
Tue Oct 01 00:00:00 UTC 2013
Calcium channel-dependent molecular maturation of photoreceptor synapses.
PloS one
Zabouri N,Haverkamp S
MA1-045 was used in immunohistochemistry to study the involvement of CaV1.4 calcium channels in photoreceptor synapse maturation in a murine knockout model
Mon Dec 09 00:00:00 UTC 2013
Distinct and atypical intrinsic and extrinsic cell death pathways between photoreceptor cell types upon specific ablation of Ranbp2 in cone photoreceptors.
PLoS genetics
Cho KI,Haque M,Wang J,Yu M,Hao Y,Qiu S,Pillai IC,Peachey NS,Ferreira PA
MA1-045 was used in immunohistochemistry to study the effects of Ranbp2 conditional knockout in cone photoreceptors on the activation of cell death pathways
Sat Jun 01 00:00:00 UTC 2013
Inverse synaptic tagging of inactive synapses via dynamic interaction of Arc/Arg3.1 with CaMKIIβ.
Cell
Okuno H,Akashi K,Ishii Y,Yagishita-Kyo N,Suzuki K,Nonaka M,Kawashima T,Fujii H,Takemoto-Kimura S,Abe M,Natsume R,Chowdhury S,Sakimura K,Worley PF,Bito H
MA1-045 was used in immunocytochemistry to study the role of Arc/Arg3.1 and CaMKIIbeta in the process of inverse synaptic tagging
Fri May 11 00:00:00 UTC 2012
Selective control of inhibitory synapse development by Slitrk3-PTPδ trans-synaptic interaction.
Nature neuroscience
Takahashi H,Katayama K,Sohya K,Miyamoto H,Prasad T,Matsumoto Y,Ota M,Yasuda H,Tsumoto T,Aruga J,Craig AM
MA1-045 was used in immunocytochemistry to identify Slitrk3-PTPdelta as an inhibitory-specific trans-synaptic organizing complex that is required for normal functional GABAergic synapse development
Sun Jan 29 00:00:00 UTC 2012
Involvement of the γ-secretase-mediated EphA4 signaling pathway in synaptic pathogenesis of Alzheimer's disease.
Brain pathology (Zurich, Switzerland)
Matsui C,Inoue E,Kakita A,Arita K,Deguchi-Tawarada M,Togawa A,Yamada A,Takai Y,Takahashi H
MA1-045 was used in western blot to study the role of gamma secretase-mediated EphA4 signaling in synaptic loss in Alzheimer's disease
Thu Nov 01 00:00:00 UTC 2012
Mitigation of augmented extrasynaptic NMDAR signaling and apoptosis in cortico-striatal co-cultures from Huntington's disease mice.
Neurobiology of disease
Milnerwood AJ,Kaufman AM,Sepers MD,Gladding CM,Zhang L,Wang L,Fan J,Coquinco A,Qiao JY,Lee H,Wang YT,Cynader M,Raymond LA
MA1-045 was used in immunocytochemistry to study changes in NMDAR signaling and apoptosis in cortico-striatal co-cultures from Huntington's disease mice
Mon Oct 01 00:00:00 UTC 2012
Retinal dysfunction, photoreceptor protein dysregulation and neuronal remodelling in the R6/1 mouse model of Huntington's disease.
Neurobiology of disease
Batcha AH,Greferath U,Jobling AI,Vessey KA,Ward MM,Nithianantharajah J,Hannan AJ,Kalloniatis M,Fletcher EL
MA1-045 was used in immunocytochemistry to investigate the changes in retinal structure and function in the R6/1 mouse model of Huntington disease
Thu Mar 01 00:00:00 UTC 2012
Glucocorticoid suppresses dendritic spine development mediated by down-regulation of caldesmon expression.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Tanokashira D,Morita T,Hayashi K,Mayanagi T,Fukumoto K,Kubota Y,Yamashita T,Sobue K
MA1-045 was used in western blot to study the role of reduced caldesmon expression in the mechanism by which glucocorticoids inhibit dendritic spine development
Wed Oct 17 00:00:00 UTC 2012
Time-dependent cross talk between spinal serotonin 5-HT2A receptor and mGluR1 subserves spinal hyperexcitability and neuropathic pain after nerve injury.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Aira Z,Buesa I,Gallego M,García del Caño G,Mendiable N,Mingo J,Rada D,Bilbao J,Zimmermann M,Azkue JJ
MA1-045 was used in immunocytochemistry to study the role of mGluR1 in 5-HTT2A-mediated spinal hyperexcitability and neuropathic pain in a rat model of nerve injury
Wed Sep 26 00:00:00 UTC 2012
Independent vesicle pools underlie different modes of release during neuronal development.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Andreae LC,Fredj NB,Burrone J
MA1-045 was used in immunocytochemistry to investigate vesicle cycling during neuronal development
Wed Feb 01 00:00:00 UTC 2012
Glutamatergic synapse formation is promoted by α7-containing nicotinic acetylcholine receptors.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Lozada AF,Wang X,Gounko NV,Massey KA,Duan J,Liu Z,Berg DK
MA1-045 was used in immunohistochemistry to study the role of nicotinic acetylcholine recptors containing the alpha-7 subunit in the formation of glutamatergic synapses
Wed May 30 00:00:00 UTC 2012
Integrin dynamics produce a delayed stage of long-term potentiation and memory consolidation.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Babayan AH,Kramár EA,Barrett RM,Jafari M,Häettig J,Chen LY,Rex CS,Lauterborn JC,Wood MA,Gall CM,Lynch G
MA1-045 was used in immunocytochemistry to study the role of beta1 integrin in long-term potentiation and the consolidation of memory
Wed Sep 12 00:00:00 UTC 2012
Formation of Golgi-derived active zone precursor vesicles.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Maas C,Torres VI,Altrock WD,Leal-Ortiz S,Wagh D,Terry-Lorenzo RT,Fejtova A,Gundelfinger ED,Ziv NE,Garner CC
MA1-045 was used in immunocytochemistry to study the cellular mechanisms underlying the generation of active zone precursor vesicles in the Golgi
Wed Aug 08 00:00:00 UTC 2012
Perisynaptic chondroitin sulfate proteoglycans restrict structural plasticity in an integrin-dependent manner.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Orlando C,Ster J,Gerber U,Fawcett JW,Raineteau O
MA1-045 was used in Immunocytochemistry-immunoflourescence to assess the effect of chondroitinase ABC-mediated digestion of chondroitin sulphate proteoglycans on dendritic spine dynamics.
Wed Dec 12 00:00:00 UTC 2012
Short-term field stimulation mimics synaptic maturation of hippocampal synapses.
The Journal of physiology
Bagley EE,Westbrook GL
MA1-045 was used in immunohistochemistry to study the role of synaptic activity in the maturation of hippocampal synapses
Sun Apr 01 00:00:00 UTC 2012
Age-dependent decline of motor neocortex but not hippocampal performance in heterozygous BDNF mice correlates with a decrease of cortical PSD-95 but an increase of hippocampal TrkB levels.
Experimental neurology
Carretón O,Giralt A,Torres-Peraza JF,Brito V,Lucas JJ,Ginés S,Canals JM,Alberch J
MA1-045 was used in immunohistochemistry and western blot to study the differential effects of the BDNF (+/-) genotype on motor neocortical and hippocampal performance in mice
Mon Oct 01 00:00:00 UTC 2012
Allopregnanolone prevents dieldrin-induced NMDA receptor internalization and neurotoxicity by preserving GABA(A) receptor function.
Endocrinology
Briz V,Parkash J,Sánchez-Redondo S,Prevot V,Suñol C
MA1-045 was used in immunoprecipitation to study the mechanism for the effect of allopregnanolone on NMDA receptor internalization and neurotoxicity
Wed Feb 01 00:00:00 UTC 2012
Actin dynamics in development of behavioral sensitization after withdrawal from long-term ethanol administration to mice.
Alcoholism, clinical and experimental research
Shibasaki M,Kurokawa K,Mizuno K,Suzuki T,Ohkuma S
MA1-045 was used in western blot to study the role of actin depolymerizing factor in actin dynamics and behavioural sensitization in mice following withdrawal from continuous ethanol
Wed Aug 01 00:00:00 UTC 2012
Co-localization of hippocampal cholinergic neurostimulating peptide precursor with collapsin response mediator protein-2 at presynaptic terminals in hippocampus.
Neuroscience letters
Kato D,Mitake S,Mizuno M,Kanamori T,Suzuki T,Ojika K,Matsukawa N
MA1-045 was used in western blot to study the interaction between HCNP and CRMP-2 at hippocampal presynaptic terminals
Thu May 31 00:00:00 UTC 2012
Determinants of synaptic strength vary across an axon arbor.
Journal of neurophysiology
Peng X,Parsons TD,Balice-Gordon RJ
MA1-045 was used in immunocytochemistry to identify the factors important in synaptic strength an axon arbor
Tue May 01 00:00:00 UTC 2012
Immunolocalization of NR1, NR2A, and PSD-95 in rat hippocampal subregions during postnatal development.
Acta histochemica
Ling W,Chang L,Song Y,Lu T,Jiang Y,Li Y,Wu Y
MA1-045 was used in immunohistochemistry to study the immunofluorescent localization of NR1, NR2A and PSD-95 during post-natal development of the rat hippocampus
Tue May 01 00:00:00 UTC 2012
Deletion of glutamate delta-1 receptor in mouse leads to aberrant emotional and social behaviors.
PloS one
Yadav R,Gupta SC,Hillman BG,Bhatt JM,Stairs DJ,Dravid SM
MA1-045 was used in western blot to study the effect of glutamate delta-1 receptor deletion on emotional and social behaviors in mice
Thu Aug 02 00:00:00 UTC 2012
Transgenic strategy for identifying synaptic connections in mice by fluorescence complementation (GRASP).
Frontiers in molecular neuroscience
Yamagata M,Sanes JR
MA1-045 was used in immunohistochemistry to use a fluorescence complementation methodology to study murine synaptic connections
Tue Oct 02 00:00:00 UTC 2012
NeuroD2 regulates the development of hippocampal mossy fiber synapses.
Neural development
Wilke SA,Hall BJ,Antonios JK,Denardo LA,Otto S,Yuan B,Chen F,Robbins EM,Tiglio K,Williams ME,Qiu Z,Biederer T,Ghosh A
MA1-045 was used in western blot to study the development of hippocampal mossy fibre synapses and the role played by the NeuroD2 transcription factor
Mon Feb 27 00:00:00 UTC 2012
Glutamate binding to the GluN2B subunit controls surface trafficking of N-methyl-D-aspartate (NMDA) receptors.
The Journal of biological chemistry
She K,Ferreira JS,Carvalho AL,Craig AM
MA1-045 was used in immunocytochemistry to study the control of NMDA receptor surface trafficking by the binding of glutamate to GluN2B subunits
Fri Aug 10 00:00:00 UTC 2012
Regulation of synaptic stability by AMPA receptor reverse signaling.
Proceedings of the National Academy of Sciences of the United States of America
Ripley B,Otto S,Tiglio K,Williams ME,Ghosh A
MA1-045 was used in immunocytochemistry to study the role of AMPA receptor reverse signaling in synaptic formation and stability
Tue Jan 04 00:00:00 UTC 2011
PSD-95 alters microtubule dynamics via an association with EB3.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Sweet ES,Previtera ML,Fernández JR,Charych EI,Tseng CY,Kwon M,Starovoytov V,Zheng JQ,Firestein BL
MA1-045 was used in immunocytochemistry to investigate the mechanism for cytoskeleton changes mediated by PSD95
Wed Jan 19 00:00:00 UTC 2011
Aberrant calcium/calmodulin-dependent protein kinase II (CaMKII) activity is associated with abnormal dendritic spine morphology in the ATRX mutant mouse brain.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Shioda N,Beppu H,Fukuda T,Li E,Kitajima I,Fukunaga K
MA1-045 was used in western blot to show the involvement of CaMKII activity in dendritic spine morphology and cognitive development
Wed Jan 05 00:00:00 UTC 2011
Morphine- and CaMKII-dependent enhancement of GIRK channel signaling in hippocampal neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Nassirpour R,Bahima L,Lalive AL,Lüscher C,Luján R,Slesinger PA
MA1-045 was used in immunocytochemistry to investigate the effect of morphine on neuronal GIRK signaling
Wed Oct 06 00:00:00 UTC 2010
LRRTMs and neuroligins bind neurexins with a differential code to cooperate in glutamate synapse development.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Siddiqui TJ,Pancaroglu R,Kang Y,Rooyakkers A,Craig AM
MA1-045 was used in immunocytochemistry to characterize the role of neurexins in synaptic differentiation and development
Wed Jun 02 00:00:00 UTC 2010
Ca2+-dependent facilitation of Cav1.3 Ca2+ channels by densin and Ca2+/calmodulin-dependent protein kinase II.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Jenkins MA,Christel CJ,Jiao Y,Abiria S,Kim KY,Usachev YM,Obermair GJ,Colbran RJ,Lee A
MA1-045 was used in immunocytochemistry to investigate the involvement of densin in CaMKII-mediated Cav1.3 modulation
Wed Apr 14 00:00:00 UTC 2010
Physiological activation of synaptic Rac>PAK (p-21 activated kinase) signaling is defective in a mouse model of fragile X syndrome.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Chen LY,Rex CS,Babayan AH,Kramár EA,Lynch G,Gall CM,Lauterborn JC
MA1-045 was used in immunohistochemistry to investigate the Rac>PAK signaling pathway in a Fmr1-knockout mouse model
Wed Aug 18 00:00:00 UTC 2010
In vivo composition of NMDA receptor signaling complexes differs between membrane subdomains and is modulated by PSD-95 and PSD-93.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Delint-Ramirez I,Fernández E,Bayés A,Kicsi E,Komiyama NH,Grant SG
MA1-045 was used in western blot to investigate the composition of NMDAR-PSD-95 complexes in lipid rafts
Wed Jun 16 00:00:00 UTC 2010
Apolipoprotein E mRNA is transported to dendrites and may have a role in synaptic structural plasticity.
Journal of neurochemistry
Oh JY,Nam YJ,Jo A,Cheon HS,Rhee SM,Park JK,Lee JA,Kim HK
MA1-045 was used in immunocytochemistry to investigate the effect of neuronal ApoE on lipid rafts and synaptic structural plasticity
Sun Aug 01 00:00:00 UTC 2010
Phosphorylation of N-methyl-D-aspartic acid receptor-associated neuronal nitric oxide synthase depends on estrogens and modulates hypothalamic nitric oxide production during the ovarian cycle.
Endocrinology
Parkash J,d'Anglemont de Tassigny X,Bellefontaine N,Campagne C,Mazure D,Buée-Scherrer V,Prevot V
MA1-045 was used in immunoprecipitation to investigate the regulation of NOS Ser1412 phosphorylation by estrogen
Tue Jun 01 00:00:00 UTC 2010
Neuroserpin regulates the density of dendritic protrusions and dendritic spine shape in cultured hippocampal neurons.
Journal of neuroscience research
Borges VM,Lee TW,Christie DL,Birch NP
MA1-045 was used in immunocytochemistry to study the role of neuroserpin in neuronal structural plasticity
Wed Sep 01 00:00:00 UTC 2010
Hippocampal N-methyl-D-aspartate receptor subunit expression profiles in a mouse model of prenatal alcohol exposure.
Alcoholism, clinical and experimental research
Samudio-Ruiz SL,Allan AM,Sheema S,Caldwell KK
MA1-045 was used in immunoprecipitation to investigate the effect of prenatal alcohol exposure on the expression of hippocampal NMDA receptor
Mon Feb 01 00:00:00 UTC 2010
Proteomics analysis reveals overlapping functions of clustered protocadherins.
Molecular & cellular proteomics : MCP
Han MH,Lin C,Meng S,Wang X
MA1-045 was used in western blot to delineate the composition of PCDH-gamma complexes and its role in neural development
Fri Jan 01 00:00:00 UTC 2010
Rab3-interacting molecule gamma isoforms lacking the Rab3-binding domain induce long lasting currents but block neurotransmitter vesicle anchoring in voltage-dependent P/Q-type Ca2+ channels.
The Journal of biological chemistry
Uriu Y,Kiyonaka S,Miki T,Yagi M,Akiyama S,Mori E,Nakao A,Beedle AM,Campbell KP,Wakamori M,Mori Y
MA1-045 was used in western blot to investigate the role of the Rab3-binding domain of Rab3-interacting molecule gamma isoforms for long lasting currents and neurotransmitter vesicle anchoring in voltage-dependent P/Q-type calcium channels
Fri Jul 09 00:00:00 UTC 2010
An unbiased expression screen for synaptogenic proteins identifies the LRRTM protein family as synaptic organizers.
Neuron
Linhoff MW,Laurén J,Cassidy RM,Dobie FA,Takahashi H,Nygaard HB,Airaksinen MS,Strittmatter SM,Craig AM
MA1-045 was used in immunocytochemistry to study the role of LRRTM family proteins identified in an expression screen as synaptic organizers
Thu Mar 12 00:00:00 UTC 2009
Coordinated changes in dendritic arborization and synaptic strength during neural circuit development.
Neuron
Peng YR,He S,Marie H,Zeng SY,Ma J,Tan ZJ,Lee SY,Malenka RC,Yu X
MA1-045 was used in immunohistochemistry to study dendritic morphological changes and its functional significance during neural circuit development
Thu Jan 15 00:00:00 UTC 2009
Interaction of postsynaptic density protein-95 with NMDA receptors influences excitotoxicity in the yeast artificial chromosome mouse model of Huntington's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Fan J,Cowan CM,Zhang LY,Hayden MR,Raymond LA
MA1-045 was used in western blot to study the roles of NMDA-type glutamate receptors in the degeneration of striatal medium-sized spiny neurons in Huntington's disease.
Wed Sep 02 00:00:00 UTC 2009
Synaptic scaling requires the GluR2 subunit of the AMPA receptor.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Gainey MA,Hurvitz-Wolff JR,Lambo ME,Turrigiano GG
MA1-045 was used in immunohistochemistry to investigate the roles of the GluR2 subunit on the expression of synaptic scaling
Wed May 20 00:00:00 UTC 2009
Estradiol induces physical association of neuronal nitric oxide synthase with NMDA receptor and promotes nitric oxide formation via estrogen receptor activation in primary neuronal cultures.
Journal of neurochemistry
d'Anglemont de Tassigny X,Campagne C,Steculorum S,Prevot V
MA1-045 was used in ChIP assay to investigate the effect of estradiol on the nNOS/PSD-95/NMDA receptor complex assembly and its mechanism
Wed Apr 01 00:00:00 UTC 2009
Synaptogenesis in purified cortical subplate neurons.
Cerebral cortex (New York, N.Y. : 1991)
McKellar CE,Shatz CJ
MA1-045 was used in immunocytochemistry to develop a culture system for studying synaptogenesis in purified cortical subplate neurons
Sat Aug 01 00:00:00 UTC 2009
Environmental enrichment induces synaptic structural modification after transient focal cerebral ischemia in rats.
Experimental biology and medicine (Maywood, N.J.)
Xu X,Ye L,Ruan Q
MA1-045 was used in western blot to study the effects of environmental enrichment on spatial memory and synaptic junctions in rats following transient focal cerebral ischemia
Sun Mar 01 00:00:00 UTC 2009
Ampakines cause sustained increases in brain-derived neurotrophic factor signaling at excitatory synapses without changes in AMPA receptor subunit expression.
Neuroscience
Lauterborn JC,Pineda E,Chen LY,Ramirez EA,Lynch G,Gall CM
MA1-045 was used in immunohistochemistry to study the enhanced BDNF signaling at excitatory synapses by ampakine treatment without affecting AMPAR protein levels
Tue Mar 03 00:00:00 UTC 2009
Subunit-selective palmitoylation regulates the intracellular trafficking of AMPA receptor.
The European journal of neuroscience
Yang G,Xiong W,Kojic L,Cynader MS
MA1-045 was used in immunoprecipitation to study the role of protein palmitoylation in the intracellular trafficking of the AMPA receptor
Wed Jul 01 00:00:00 UTC 2009
Diagnostic utility of expression of claudins in non-small cell lung cancer: different expression profiles in squamous cell carcinomas and adenocarcinomas.
Pathology, research and practice
Jung JH,Jung CK,Choi HJ,Jun KH,Yoo J,Kang SJ,Lee KY
MA1-045 was used in immunohistochemistry to study the diagnostic value of claudin expression in non-small cell lung cancer
Tue Aug 18 00:00:00 UTC 2009
Molecular dissociation of the role of PSD-95 in regulating synaptic strength and LTD.
Neuron
Xu W,Schlüter OM,Steiner P,Czervionke BL,Sabatini B,Malenka RC
MA1-045 was used in western blot to study whether it is possible to dissociate the effects of PSD-95 on AMPAR-mediated synaptic responses and LTD
Thu Jan 24 00:00:00 UTC 2008
Synaptic signaling by all-trans retinoic acid in homeostatic synaptic plasticity.
Neuron
Aoto J,Nam CI,Poon MM,Ting P,Chen L
MA1-045 was used in western blot to study the role of synaptic signaling by all-trans retinoic acid in regulating synaptic plasticity
Thu Oct 23 00:00:00 UTC 2008
Importin-mediated retrograde transport of CREB2 from distal processes to the nucleus in neurons.
Proceedings of the National Academy of Sciences of the United States of America
Lai KO,Zhao Y,Ch'ng TH,Martin KC
MA1-045 was used in immunocytochemistry to investigate the role of importin in the retrograde transport of CREB2 in neurons
Tue Nov 04 00:00:00 UTC 2008
Extracellular proteolysis by matrix metalloproteinase-9 drives dendritic spine enlargement and long-term potentiation coordinately.
Proceedings of the National Academy of Sciences of the United States of America
Wang XB,Bozdagi O,Nikitczuk JS,Zhai ZW,Zhou Q,Huntley GW
MA1-045 was used in immunocytochemistry to investigate the role of matrix metalloproteinase-9 in spine enlargement and synaptic potentiation .
Tue Dec 09 00:00:00 UTC 2008
Differential changes in synaptic proteins in the Alzheimer frontal cortex with marked increase in PSD-95 postsynaptic protein.
Journal of Alzheimer's disease : JAD
Leuba G,Savioz A,Vernay A,Carnal B,Kraftsik R,Tardif E,Riederer I,Riederer BM
MA1-045 was used in immunohistochemistry to study the changes in synaptic proteins in the Alzheimer frontal cortex
Mon Sep 01 00:00:00 UTC 2008
Projections from basal forebrain to prefrontal cortex comprise cholinergic, GABAergic and glutamatergic inputs to pyramidal cells or interneurons.
The European journal of neuroscience
Henny P,Jones BE
MA1-045 was used in immunohistochemistry to study the presynaptic and postsynaptic components of the basal forebrain projection to the prefrontal cortex in the rat
Fri Feb 01 00:00:00 UTC 2008
Preservation of long-term memory and synaptic plasticity despite short-term impairments in the Tc1 mouse model of Down syndrome.
Learning & memory (Cold Spring Harbor, N.Y.)
Morice E,Andreae LC,Cooke SF,Vanes L,Fisher EM,Tybulewicz VL,Bliss TV
MA1-045 was used in western blot to study long-term memory and synaptic plasticity in a mouse model of Down syndrome
Tue Jul 01 00:00:00 UTC 2008
Regulation of CNS synapses by neuronal MHC class I.
Proceedings of the National Academy of Sciences of the United States of America
Goddard CA,Butts DA,Shatz CJ
MA1-045 was used in immunocytochemistry to study the role of postsynaptically localized MHCl in synaptic development and function.
Tue Apr 17 00:00:00 UTC 2007
Abeta oligomer-induced aberrations in synapse composition, shape, and density provide a molecular basis for loss of connectivity in Alzheimer's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Lacor PN,Buniel MC,Furlow PW,Clemente AS,Velasco PT,Wood M,Viola KL,Klein WL
MA1-045 was used in immunoprecipitation to investigate the ability of soluble Abeta-derived oligomers to affect synaptic composition and function.
Wed Jan 24 00:00:00 UTC 2007
Changes in synaptic morphology accompany actin signaling during LTP.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Chen LY,Rex CS,Casale MS,Gall CM,Lynch G
MA1-045 was used in immunocytochemistry to investigate the role of actin regulatory pathway in synaptic morphology during long-term potentiation.
Wed May 16 00:00:00 UTC 2007
SynCAMs organize synapses through heterophilic adhesion.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Fogel AI,Akins MR,Krupp AJ,Stagi M,Stein V,Biederer T
MA1-045 was used in blocking/activating experiments to investigate the expression and localization of SynCAM 1 and 2 in developing neurons .
Wed Nov 14 00:00:00 UTC 2007
Distinct structural and ionotropic roles of NMDA receptors in controlling spine and synapse stability.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Alvarez VA,Ridenour DA,Sabatini BL
MA1-045 was used in immunocytochemistry to demonstrate the effect of NMDA-type glutamate receptors on dendritic spines and active synapses.
Wed Jul 11 00:00:00 UTC 2007
Evidence that long-term potentiation occurs within individual hippocampal synapses during learning.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Fedulov V,Rex CS,Simmons DA,Palmer L,Gall CM,Lynch G
MA1-045 was used in immunocytochemistry to investigate the mechanism for long-term potentiation during learning.
Wed Jul 25 00:00:00 UTC 2007
Differential expression of PSD proteins in age-related spatial learning impairments.
Neurobiology of aging
Nyffeler M,Zhang WN,Feldon J,Knuesel I
MA1-045 was used in immunohistochemistry to study age-induced changes in postsynaptic density protein expression in spatial learning impairments
Mon Jan 01 00:00:00 UTC 2007
Sex differences in neurotransmission parameters in response to repeated mild restraint stress exposures in intact male, female and ovariectomised female rats.
Journal of neuroendocrinology
Khurana RC,Devaud LL
MA1-045 was used in western blot to study gender differences in the neuronal response to repeated mild restraint stress exposures in rats
Sun Jul 01 00:00:00 UTC 2007
Co-expression of myosin II regulatory light chain and the NMDAR1 subunit in neonatal and adult mouse brain.
Brain research bulletin
Kioussi C,Appu M,Löhr CV,Fischer KA,Bajaj G,Leid M,Ishmael JE
MA1-045 was used in western blot to study the expression of myosin II regulatory light chain and NMDAR1 in neonatal and adult mouse brain
Thu Nov 01 00:00:00 UTC 2007
The TRPM7 ion channel functions in cholinergic synaptic vesicles and affects transmitter release.
Neuron
Krapivinsky G,Mochida S,Krapivinsky L,Cibulsky SM,Clapham DE
MA1-045 was used in western blot to study the role of synaptic vesicle TRPM7 in neurotransmitter release by sympathetic neurones
Thu Nov 09 00:00:00 UTC 2006
Alternative N-terminal domains of PSD-95 and SAP97 govern activity-dependent regulation of synaptic AMPA receptor function.
Neuron
Schlüter OM,Xu W,Malenka RC
MA1-045 was used in western blot to study the role of alternative N-terminal domains of PSD-95 and SAP97 in controling the function of the synaptic AMPA receptor
Thu Jul 06 00:00:00 UTC 2006
A preformed complex of postsynaptic proteins is involved in excitatory synapse development.
Neuron
Gerrow K,Romorini S,Nabi SM,Colicos MA,Sala C,El-Husseini A
MA1-045 was used in immunocytochemistry to study the role of preformed complexes of postsynaptic proteins in the formation of excitatory synapses
Thu Feb 16 00:00:00 UTC 2006
The role of protein interaction motifs in regulating the polarity and clustering of the metabotropic glutamate receptor mGluR1a.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Das SS,Banker GA
MA1-045 was used in immunocytochemistry to investigate the regulation of dendritic agglomeration of the metabotropic glutamate receptor mGluR1a by protein interaction motifs.
Wed Aug 02 00:00:00 UTC 2006
The stop signal revised: immature cerebellar granule neurons in the external germinal layer arrest pontine mossy fiber growth.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Manzini MC,Ward MS,Zhang Q,Lieberman MD,Mason CA
MA1-045 was used in immunocytochemistry to study the role of immature cerebellar granule neurons in the external germinal layer in arresting pontine mossy fiber growth
Wed May 31 00:00:00 UTC 2006
Matrix metalloproteinase-7 disrupts dendritic spines in hippocampal neurons through NMDA receptor activation.
Journal of neurochemistry
Bilousova TV,Rusakov DA,Ethell DW,Ethell IM
MA1-045 was used in immunocytochemistry to study the role of NMDA receptor activation in the MMP-7-mediated disruption of dendritic spines in hippocampal neurons
Sat Apr 01 00:00:00 UTC 2006
Novel putative targets of N-ethylmaleimide sensitive fusion protein (NSF) and alpha/beta soluble NSF attachment proteins (SNAPs) include the Pak-binding nucleotide exchange factor betaPIX.
Journal of cellular biochemistry
Martin HG,Henley JM,Meyer G
MA1-045 was used in immunocytochemistry to to identify novel targets of the NSF-SNAP complex
Wed Nov 01 00:00:00 UTC 2006
Enhanced activation of Ca2+/calmodulin-dependent protein kinase II upon downregulation of cyclin-dependent kinase 5-p35.
Journal of neuroscience research
Hosokawa T,Saito T,Asada A,Ohshima T,Itakura M,Takahashi M,Fukunaga K,Hisanaga S
MA1-045 was used in immunocytochemistry and western blot to study the role of Cdk5-p35 downregulation in enhanced CaMKII activation
Fri Sep 01 00:00:00 UTC 2006
Role of the synprint site in presynaptic targeting of the calcium channel CaV2.2 in hippocampal neurons.
The European journal of neuroscience
Szabo Z,Obermair GJ,Cooper CB,Zamponi GW,Flucher BE
MA1-045 was used in immunocytochemistry to study the role of the synprint site in presynaptic targeting in cultured hippocampal neurons
Tue Aug 01 00:00:00 UTC 2006
Semaphorin3A regulates synaptic function of differentiated hippocampal neurons.
The European journal of neuroscience
Bouzioukh F,Daoudal G,Falk J,Debanne D,Rougon G,Castellani V
MA1-045 was used in western blot to study the role of semaphorin3A in regulating synaptic function in the adult brain
Mon May 01 00:00:00 UTC 2006
BRAG1, a Sec7 domain-containing protein, is a component of the postsynaptic density of excitatory synapses.
Brain research
Murphy JA,Jensen ON,Walikonis RS
MA1-045 was used in immunocytochemistry to study the occurrence and role of BRAG1 in the postsynaptic density of excitatory synapses
Mon Nov 20 00:00:00 UTC 2006
NMDA receptor composition differs among anatomically diverse malformations of cortical development.
Journal of neuropathology and experimental neurology
Finardi A,Gardoni F,Bassanini S,Lasio G,Cossu M,Tassi L,Caccia C,Taroni F,LoRusso G,Di Luca M,Battaglia G
MA1-045 was used in western blot to study the molecular composition of the NMDA receptor in anatomically diverse malformations of cortical development
Fri Sep 01 00:00:00 UTC 2006
Vesicular glutamate (VGlut), GABA (VGAT), and acetylcholine (VACht) transporters in basal forebrain axon terminals innervating the lateral hypothalamus.
The Journal of comparative neurology
Henny P,Jones BE
MA1-045 was used in immunohistochemistry to study the relationship between chemically specific basal forebrain neurons and innervation to the lateral hypothalamus
Thu Jun 01 00:00:00 UTC 2006
Innervation of orexin/hypocretin neurons by GABAergic, glutamatergic or cholinergic basal forebrain terminals evidenced by immunostaining for presynaptic vesicular transporter and postsynaptic scaffolding proteins.
The Journal of comparative neurology
Henny P,Jones BE
MA1-045 was used in immunohistochemistry to study the relationship between orexin/hypocretin neurons and GABAergic, glutamatergic or cholinergic basal forebrain neurons
Fri Dec 01 00:00:00 UTC 2006
Differential regulation of neuregulin 1 expression by progesterone in astrocytes and neurons.
Neuron glia biology
Lacroix-Fralish ML,Tawfik VL,Nutile-McMenemy N,Harris BT,Deleo JA
MA1-045 was used in immunocytochemistry to study how NRG1 is regulated by gonadal hormones, progesterone and 17beta-estradiol in astrocytes and neurons in vitro
Wed Nov 01 00:00:00 UTC 2006
Thrombospondins are astrocyte-secreted proteins that promote CNS synaptogenesis.
Cell
Christopherson KS,Ullian EM,Stokes CC,Mullowney CE,Hell JW,Agah A,Lawler J,Mosher DF,Bornstein P,Barres BA
MA1-045 was used in immunohistochemistry to study the role of thrombospondins secreted by immature astrocytes in promoting CNS synaptogenesis
Fri Feb 11 00:00:00 UTC 2005
mPins modulates PSD-95 and SAP102 trafficking and influences NMDA receptor surface expression.
Nature cell biology
Sans N,Wang PY,Du Q,Petralia RS,Wang YX,Nakka S,Blumer JB,Macara IG,Wenthold RJ
MA1-045 was used in immunocytochemistry to study the mechanism of mPins mediated regulation of the number and morphology of dendritic spines
Thu Dec 01 00:00:00 UTC 2005
A GIT1/PIX/Rac/PAK signaling module regulates spine morphogenesis and synapse formation through MLC.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Zhang H,Webb DJ,Asmussen H,Niu S,Horwitz AF
MA1-045 was used in immunocytochemistry to investigate the role of the signaling complex GIT1, PIX, Rac, and PAK in the regulation of spine morphogenesis and synapse formation.
Wed Mar 30 00:00:00 UTC 2005
NMDA receptor activation mediates copper homeostasis in hippocampal neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Schlief ML,Craig AM,Gitlin JD
MA1-045 was used in immunocytochemistry to study the mechanisms for copper homeostasis in hippocampal neurons.
Wed Jan 05 00:00:00 UTC 2005
NMDA receptor-dependent synaptic translocation of insulin receptor substrate p53 via protein kinase C signaling.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Hori K,Yasuda H,Konno D,Maruoka H,Tsumoto T,Sobue K
MA1-045 was used in immunocytochemistry to investigate the involvement of insulin receptor substrate p53 in NMDA receptor-linked synaptic plasticity.
Wed Mar 09 00:00:00 UTC 2005
Glycine taken up through GLYT1 and GLYT2 heterotransporters into glutamatergic axon terminals of mouse spinal cord elicits release of glutamate by homotransporter reversal and through anion channels.
Biochemical pharmacology
Raiteri L,Stigliani S,Siri A,Passalacqua M,Melloni E,Raiteri M,Bonanno G
MA1-045 was used in western blot to study the mechanisms by which glycine uptake into glutamatergic axon terminals of mouse spinal cord via GLYT1 and GLYT2 promotes glutamate release
Sat Jan 01 00:00:00 UTC 2005
Differential adaptations in GABAergic and glutamatergic systems during ethanol withdrawal in male and female rats.
Alcoholism, clinical and experimental research
Alele PE,Devaud LL
MA1-045 was used in western blot to study gender differences in the GABAergic and glutamatergic systems during ethanol withdrawal in rats
Wed Jun 01 00:00:00 UTC 2005
Association of an A-kinase-anchoring protein signaling scaffold with cadherin adhesion molecules in neurons and epithelial cells.
Molecular biology of the cell
Gorski JA,Gomez LL,Scott JD,Dell'Acqua ML
MA1-045 was used in immunocytochemistry to study the interaction of AKAP basic domains with cadherin adhesion molecules at neuronal synapses and epithelial adherens junctions.
Mon Aug 01 00:00:00 UTC 2005
Exercise affects glutamate receptors in postsynaptic densities from cortical mice brain.
Brain research
Dietrich MO,Mantese CE,Porciuncula LO,Ghisleni G,Vinade L,Souza DO,Portela LV
MA1-045 was used in western blot to study whether voluntary exercise in mice can affect glutamatergic synapses in the postsynaptic density
Wed Dec 14 00:00:00 UTC 2005
Synapse composition and organization following chronic activity blockade in cultured hippocampal neurons.
The Journal of comparative neurology
Harms KJ,Craig AM
MA1-045 was used in immunocytochemistry to study the effect of activity on synapse composition and organization in central nerve system
Mon Sep 12 00:00:00 UTC 2005
Molecular and functional characterization of the electroneutral Na/HCO3 cotransporter NBCn1 in rat hippocampal neurons.
The Journal of biological chemistry
Cooper DS,Saxena NC,Yang HS,Lee HJ,Moring AG,Lee A,Choi I
MA1-045 was used in immunocytochemistry to study properties of the electroneutral Na/HCO3 cotransporter NBCn1 present in rat hippocampal neurons
Fri May 06 00:00:00 UTC 2005
Deletion of the neuron-specific protein delta-catenin leads to severe cognitive and synaptic dysfunction.
Current biology : CB
Israely I,Costa RM,Xie CW,Silva AJ,Kosik KS,Liu X
MA1-045 was used in western blot to study the effect of neuron-specific delta-catenin deletion on cognitive and synaptic function in knockout mice
Tue Sep 21 00:00:00 UTC 2004
Synaptic targeting by Alzheimer's-related amyloid beta oligomers.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Lacor PN,Buniel MC,Chang L,Fernandez SJ,Gong Y,Viola KL,Lambert MP,Velasco PT,Bigio EH,Finch CE,Krafft GA,Klein WL
MA1-045 was used in immunocytochemistry to demonstrate the effect of amyloid beta oligomers on memory function in early Alzheimer disease.
Wed Nov 10 00:00:00 UTC 2004
BDNF regulates the translation of a select group of mRNAs by a mammalian target of rapamycin-phosphatidylinositol 3-kinase-dependent pathway during neuronal development.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Schratt GM,Nigh EA,Chen WG,Hu L,Greenberg ME
MA1-045 was used in immunocytochemistry to study BDNF-regulated translation of mRNAs during neuronal development
Wed Aug 18 00:00:00 UTC 2004
Molecular determinants of synapsin targeting to presynaptic terminals.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Gitler D,Xu Y,Kao HT,Lin D,Lim S,Feng J,Greengard P,Augustine GJ
MA1-045 was used in immunohistochemistry to study the targeting of synapsin to presynaptic terminals.
Wed Apr 07 00:00:00 UTC 2004
Gene expression analysis of the critical period in the visual cortex.
Molecular and cellular neurosciences
Ossipow V,Pellissier F,Schaad O,Ballivet M
MA1-045 was used in western blot to study gene expression during the critical period in the visual cortex
Wed Sep 01 00:00:00 UTC 2004
Ubiquitination regulates PSD-95 degradation and AMPA receptor surface expression.
Neuron
Colledge M,Snyder EM,Crozier RA,Soderling JA,Jin Y,Langeberg LK,Lu H,Bear MF,Scott JD
MA1-045 was used in immunocytochemistry to investigate the role of ubiquitination for PSD-95 degradation and AMPA receptor surface expression
Thu Oct 30 00:00:00 UTC 2003
Synapse formation is regulated by the signaling adaptor GIT1.
The Journal of cell biology
Zhang H,Webb DJ,Asmussen H,Horwitz AF
MA1-045 was used in immunocytochemistry to investigate the regulation of synapse formation by the signaling adaptor GIT1.
Mon Apr 14 00:00:00 UTC 2003
The small conductance Ca2+-activated K+ channel SK3 is localized in nerve terminals of excitatory synapses of cultured mouse hippocampal neurons.
The European journal of neuroscience
Obermair GJ,Kaufmann WA,Knaus HG,Flucher BE
MA1-045 was used in immunocytochemistry to study the localization of the small conductance SK3 channel in nerve terminals of excitatory synapses of cultured mouse hippocampal neurons
Sat Feb 01 00:00:00 UTC 2003
The NMDA receptor complex is altered in an animal model of human cerebral heterotopia.
Journal of neuropathology and experimental neurology
Gardoni F,Pagliardini S,Setola V,Bassanini S,Cattabeni F,Battaglia G,Di Luca M
MA1-045 was used in immunoprecipitation to study changes in the molecular organization of the NMDA receptor complex in an animal model of human cerebral heterotopia
Sun Jun 01 00:00:00 UTC 2003
Rapid synaptic remodeling by protein kinase C: reciprocal translocation of NMDA receptors and calcium/calmodulin-dependent kinase II.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Fong DK,Rao A,Crump FT,Craig AM
MA1-045 was used in immunocytochemistry to show that PKC activation induced no change in the synaptic scaffolding protein PSD-95
Fri Mar 15 00:00:00 UTC 2002
The postsynaptic density and dendritic raft localization of PSD-Zip70, which contains an N-myristoylation sequence and leucine-zipper motifs.
Journal of cell science
Konno D,Ko JA,Usui S,Hori K,Maruoka H,Inui M,Fujikado T,Tano Y,Suzuki T,Tohyama K,Sobue K
MA1-045 was used in immunocytochemistry to study the expression and localization of PSD-Zip70.
Sun Dec 01 00:00:00 UTC 2002
Synbindin, A novel syndecan-2-binding protein in neuronal dendritic spines.
The Journal of cell biology
Ethell IM,Hagihara K,Miura Y,Irie F,Yamaguchi Y
MA1-045 was used in immunoprecipitation to investigate the role of PSD-95 during the formation of spine induced by syndecan-2.
Mon Oct 02 00:00:00 UTC 2000
Postsynaptic scaffolds of excitatory and inhibitory synapses in hippocampal neurons: maintenance of core components independent of actin filaments and microtubules.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Allison DW,Chervin AS,Gelfand VI,Craig AM
MA1-045 was used in immunocytochemistry to study the structural scaffolding of excitatory and inhibitory synapses in hippocampal neurons and the cytoskeletal involvement.
Thu Jun 15 00:00:00 UTC 2000
Mismatched appositions of presynaptic and postsynaptic components in isolated hippocampal neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Rao A,Cha EM,Craig AM
MA1-045 was used in immunocytochemistry to investigate the role for glutamate and GABA receptors in regulating mismatching of presynaptic and postsynaptic components in isolated hippocampal neurons.
Wed Nov 15 00:00:00 UTC 2000
Interaction of the postsynaptic density-95/guanylate kinase domain-associated protein complex with a light chain of myosin-V and dynein.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Naisbitt S,Valtschanoff J,Allison DW,Sala C,Kim E,Craig AM,Weinberg RJ,Sheng M
MA1-045 was used in immunocytochemistry to demonstrate that the GKAP/DLC interaction is involved in the postsynaptic trafficking of GKAP.
Thu Jun 15 00:00:00 UTC 2000
Cell surface heparan sulfate proteoglycan syndecan-2 induces the maturation of dendritic spines in rat hippocampal neurons.
The Journal of cell biology
Ethell IM,Yamaguchi Y
MA1-045 was used in immunocytochemistry to investigate the role of the cell surface heparan sulfate proteoglycan syndecan-2 during the maturation of dendritic spines
Mon Feb 08 00:00:00 UTC 1999
Citron binds to PSD-95 at glutamatergic synapses on inhibitory neurons in the hippocampus.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Zhang W,Vazquez L,Apperson M,Kennedy MB
MA1-045 was used in immunocytochemistry to investigate the interaction between citron and PSD-95 at synapses
Fri Jan 01 00:00:00 UTC 1999
PSD-95 assembles a ternary complex with the N-methyl-D-aspartic acid receptor and a bivalent neuronal NO synthase PDZ domain.
The Journal of biological chemistry
Christopherson KS,Hillier BJ,Lim WA,Bredt DS
MA1-045 was used in western blot to study the formation of a postsynaptic protein complex containning PSD-95, nNOS and NMDA receptors
Fri Sep 24 00:00:00 UTC 1999
PDZ proteins bind, cluster, and synaptically colocalize with Eph receptors and their ephrin ligands.
Neuron
Torres R,Firestein BL,Dong H,Staudinger J,Olson EN,Huganir RL,Bredt DS,Gale NW,Yancopoulos GD
MA1-045 was used in western blot to investigate the association of PDZ proteins with Eph receptors and their ephrin ligands
Tue Dec 01 00:00:00 UTC 1998
Immunocytochemical localization of the postsynaptic density protein PSD-95 in the mammalian retina.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Koulen P,Fletcher EL,Craven SE,Bredt DS,Wässle H
MA1-045 was used in immunocytochemistry to locate the postsynaptic density protein PSD-95 in the mammalian retina
Tue Dec 01 00:00:00 UTC 1998
Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95.
Science (New York, N.Y.)
Kornau HC,Schenker LT,Kennedy MB,Seeburg PH
MA1-045 was used in immunocytochemistry to investigate the interaction between NMDA and PSD-95
Fri Sep 22 00:00:00 UTC 1995
