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Invitrogen
PSD93 Recombinant Rabbit Monoclonal Antibody (7H7L3)
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PSD93 Antibody (701999) in ICC/IF
Immunofluorescence analysis was performed on fixed and permeabilized SH-SY5Y cells for detection of endogenous Chapsyn-110 using Anti-Chapsyn-110 Recombinant Rabbit Monoclonal Antibody (Product # 701999, 2 µg/mL) and labeled with Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ Secondary Antibody, Alexa Fluor® 488 conjugate (Product # A27034, 1:2000). Panel a) shows representative cells that were stained for detection and localization of Chapsyn-110 protein (green), Panel b) is stained for nuclei (blue) using SlowFade® Gold Antifade Mountan... View More
产品信息
701999
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
Expi293
分类
Recombinant Monoclonal
类型
Antibody
克隆号
7H7L3
抗原
Protein corresponding to Human DLG2 (aa 250-430)
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.2
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
产品详细信息
This antibody is predicted to react with Rat, Mouse, Monkey and Chicken.
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
靶标信息
PSD-93, also known as chapsyn-110, is one of a family of plasma membrane-associated proteins found in synaptic junctions. PSD-93 is unique among family members in its expression in Purkinje neuron cell bodies and dendrites. PSD-93 has three ~90 amino acid repeats called PDZ domains, a single interior SH3 domain, and a carboxyl-terminal guanylate kinase homology (GuK) domain that is enzymatically inactive. It is hypothesized that PDZ-domain interactions play a role in receptor and channel clustering which contributes to neuronal plasticiyt. PSD-93 is believed to participate in the clustering of certain proteins, including NMDA receptors and shaker-type potassium channels at the synaptic membrane. There are two principal modes of interaction between PSD-93 and other proteins. NMDA receptors and shaker-type potassium channels both share C-terminal sequence homology consisting of a threonine/serine-X-valine-COOH (T/SXV) motif. Other neuronal proteins that share this motif may interact with PSD-93 by binding to its PDZ domains. Neuronal nitric oxide synthase (nNOS), which lacks the T/SXV motif but which has its own PDZ domain, has been shown to associate with PSD-93 in vitro through a pseudo-homotypic PDZ-PDZ interaction.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Channel-associated protein of synapse-110; channel-associated protein of synapses, 110kDa; Chapsyn-1; Chapsyn-110; discs large 2; discs large homolog 2; discs, large homolog 2; discs, large homolog 2, chapsyn-110; Disks large homolog 2; Postsynaptic density protein PSD-93; protein phosphatase 1, regulatory subunit 58; synaptic density protein PSD-93
基因别名: A330103J02Rik; B230218P12Rik; B330007M19Rik; chapsyn-110; DLG2; Dlgh2; Gm1197; PPP1R58; PSD-93; PSD93
UniProt ID: (Human) Q15700, (Mouse) Q91XM9, (Rat) Q63622
Entrez Gene ID: (Human) 1740, (Mouse) 23859, (Rat) 64053
chemical synaptic transmission
nervous system development
negative regulation of phosphatase activity
sensory perception of pain
receptor clustering
establishment or maintenance of epithelial cell apical/basal polarity
GMP metabolic process
GDP metabolic process
receptor localization to synapse
neuronal ion channel clustering
nucleotide phosphorylation
