Search Thermo Fisher Scientific
图: 1 / 5
Immunogen sequence: MSSIGTGYDL SASTFSPDGR VFQVEYAMKA VENSSTAIGI RCKDGVVFGV EKLVLSKLYE EGSNKRLFNV DRHVGMAVAG LLADARSLAD IAREEASNFR SNFGYNIPLK HLADRVAMYV HAYTLYSAVR PFGCSFMLGS YSVNDGAQLY MIDPSGVSYG YWGCAIGKAR QAAKTEIEKL QMKEMTCRDI VKEVAKIIYI VHDEVKDKAF ELELSWVGEL TNGRHEIVPK DIREEAEKYA KESLKEEDES DDDNM; Positive Samples: MCF-7, DU145, HL-60, PC-3, Mouse liver, Mouse spleen; Cellular Location: Cytoplasm, Nucleus
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Two alternative transcripts encoding different isoforms have been identified.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Macropain subunit C8; Multicatalytic endopeptidase complex subunit C8; multicatalytic proteinase subunit K; proteasome (prosome, macropain) subunit, alpha type, 3; Proteasome component C8; Proteasome subunit alpha type-3; proteasome subunit C8; Proteasome subunit K; PSA3; testicular secretory protein Li 43
基因别名: HC8; Lmpc8; PSC3; PSC8; PSMA3; Psma3l
UniProt ID: (Human) P25788, (Mouse) O70435, (Rat) P18422
Entrez Gene ID: (Human) 5684, (Mouse) 19167, (Rat) 29670
分子生物学功能:
protease