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Invitrogen
PSMB7 Polyclonal Antibody
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产品信息
PA1-979
产品规格
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic Peptide: C E(263) I E V L E E T V Q T M D T S(NH2)(277)
偶联物
形式
Liquid
浓度
1 mg/mL
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
产品详细信息
PA1-979 detects proteasome 20S Z (also known as the beta 2 subunit) from purified bovine and human 26S proteasome samples.
PA1-979 has been successfully used in Western blot procedures. By Western blot, this antibody detects an ~29 kDa protein representing proteasome 20S Z from purified human 26S proteasome.
The PA1-979 immunizing peptides correspond to amino acid residues 263-277 from human proteasome 20S Z protein. This sequence is completely conserved in mouse and 97% conserved in rat protein. PA1-979 immunizing peptide (Cat. # PEP-175) is available for use in neutralization and control procedures.
靶标信息
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit in the proteasome. Expression of this catalytic subunit is downregulated by gamma interferon and proteolytic processing is required to generate a mature subunit. This subunit is not present in the immunoproteasome and is replaced by catalytic subunit 2i (proteasome beta 10 subunit).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
