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The antibody detects endogenous levels of total Persephin protein.
Persephin is a disulfide-linked, homodimeric, neurotrophic factor structurally related to GDNF, artemin, and neurturin. These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. Persephin signals through a multicomponent receptor system, composed of RET and one of four GFR alpha (alpha1-alpha4) receptors. The GFRalpha4 was first identified in chicken, and was later shown to be the preferential binding subunit for persephin. Persephin promotes the survival of ventral midbrain dopaminergic neurons and motor neurons after sciatic nerve oxotomy, and, like GDNF, promotes ureteric bud branching. However, in contrast to GDNF and neurturin, persephin does not support the survival of peripheral neurons.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Persephin; PSP
基因别名: PSP; PSPN
UniProt ID: (Human) O60542
Entrez Gene ID: (Human) 5623
分子生物学功能: neurotrophic factor