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Invitrogen
PTGER4 Polyclonal Antibody
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PTGER4 Antibody (PA5-35259) in IHC (P)
Immunohistochemistry analysis of PTGER4 in paraffin-embedded human brain section. Samples were incubated with PTGER4 polyclonal antibody (Product # PA5-35259) using a dilution of 1:25 followed by an undiluted biotinylated goat polyvalent antibody was used as the secondary, followed by DAB staining.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-35259
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
KLH conjugated synthetic peptide between 242-269 amino acids from the central region of human PTGER4
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.3 mg/mL
规格
120 µg
纯化类型
Protein A, Antigen affinity chromatography
保存液
PBS, pH 7.4
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
This antibody is predicted to react with bovine, rat and rabbit based on sequence homology.
靶标信息
The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2. This receptor can activate T-cell factor signaling. It has been shown to mediate PGE2 induced expression of early growth response 1, regulate the level and stability of cyclooxygenase-2 mRNA, and lead to the phosphorylation of glycogen synthase kinase-3. Knockout studies in mice suggest that this receptor may be involved in the neonatal adaptation of circulatory system, osteoporosis, as well as initiation of skin immune responses.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: EP1; MGC126583; PGE receptor EP4 subtype; PGE2 receptor EP4 subtype; Prostaglandin E2 receptor EP4 subtype; Prostanoid EP4 receptor
基因别名: EP4; PTGER2; PTGER4; Ptgerep4
UniProt ID: (Mouse) P32240
Entrez Gene ID: (Mouse) 19219
signal transduction
G-protein coupled receptor signaling pathway
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
adenylate cyclase-activating G-protein coupled receptor signaling pathway
JNK cascade
intestine smooth muscle contraction
positive regulation of smooth muscle cell migration
regulation of ossification
positive regulation of cAMP biosynthetic process
response to lipopolysaccharide
positive regulation of interleukin-8 production
negative regulation of integrin activation
positive regulation of urine volume
positive regulation of renal sodium excretion
T-helper cell differentiation
positive regulation of bone resorption
negative regulation of cytokine secretion
positive regulation of cytokine secretion
negative regulation of inflammatory response
positive regulation of inflammatory response
negative regulation of oxidoreductase activity
regulation of stress fiber assembly
bone development
positive regulation of mucus secretion
ERK1 and ERK2 cascade
ductus arteriosus closure
positive regulation of hyaluronan biosynthetic process
positive regulation of ovarian follicle development
positive regulation of antral ovarian follicle growth
positive regulation of neutrophil extravasation
negative regulation of eosinophil extravasation
negative regulation of peroxidase activity
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