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Invitrogen
PTGES2 Polyclonal Antibody
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产品信息
PA5-120215
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 88-377 of human PTGES2 (NP_079348.1).
偶联物
形式
Liquid
浓度
2.72 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Positive test controls include: 293T, HeLa, BT-474, HL-60, Rat brain. The target is usually found in the following locations: Cytoplasm, Golgi apparatus membrane, Single-pass membrane protein, perinuclear region.
Immunogen sequence: ERSAAQLSLS SRLQLTLYQY KTCPFCSKVR AFLDFHALPY QVVEVNPVRR AEIKFSSYRK VPILVAQEGE SSQQLNDSSV IISALKTYLV SGQPLEEIIT YYPAMKAVNE QGKEVTEFGN KYWLMLNEKE AQQVYGGKEA RTEEMKWRQW ADDWLVHLIS PNVYRTPTEA LASFDYIVRE GKFGAVEGAV AKYMGAAAMY LISKRLKSRH RLQDNVREDL YEAADKWVAA VGKDRPFMGG QKPNLADLAV YGVLRVMEGL DAFDDLMQHT HIQPWYLRVE RAITEASPAH
靶标信息
The PTGES2 gene encodes for the enzyme prostaglandin E synthase 2 (PTGES2), which is crucial for the biosynthesis of prostaglandin E2 (PGE2) from arachidonic acid. This enzyme operates downstream of the cyclooxygenase (COX) pathway, particularly interacting with COX-1 and COX-2 enzymes. PTGES2 is involved in various physiological and pathological processes by generating PGE2, which functions in inflammation, fever generation, and pain. Notably, PTGES2 is a membrane-associated protein and is distinct in its role compared to other prostaglandin synthases due to its specific functional and regulatory properties. Its activity is essential in fine-tuning the levels of PGE2 in tissues, impacting numerous signaling cascades, including those involved in immune responses and vascular functions.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: FLJ14038; gamma-interferon-activated transcriptional element-binding factor 1; GATE-binding factor 1; GBF-1; membrane-associated prostaglandin E synthase 2; Membrane-associated prostaglandin E synthase-2; MGC11289; Microsomal prostaglandin E synthase 2; microsomal prostaglandin E synthase-2; mPGE synthase-2; mPGES-2; Prostaglandin E synthase 2; Prostaglandin-H(2) E-isomerase; RP11-395P17.2
基因别名: 0610038H10Rik; C79137; C9orf15; GBF-1; GBF1; mPGES-2; Mpges2; PGES2; PTGES2
UniProt ID: (Human) Q9H7Z7, (Mouse) Q8BWM0
Entrez Gene ID: (Human) 80142, (Rat) 311865, (Mouse) 96979
