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PA1-9532 detects Thymosin in human, mouse, pig and rat samples.
PA1-9532 has been successfully used in ELISA procedures.
PA1-9532 immunogen is a synthetic peptide based on human thymosin protein.
The thymus gland produces several hormones or hormone-like substances which are derived from a polypeptide precursor containing (in the rat) 113 amino acids and known as prothymosin-alpha. A peptide containing 28 amino acid residues, named thymosin-alpha-1, was originally isolated from calf thymosin fraction 5 and shown to restore various aspects of immune function in several in vitro and invivo test systems. Thymosin-alpha-1 was subsequently isolated from a similar fraction from human thymosin and reported to have the same amino acid sequence as bovine thymosin-alpha-1. In 2003, Jiang et al. identified a pathway that regulates mitochondria-initiated caspase activity. In this pathway, putative human HLA class II-associated protein (PHAP) promoted caspase-9 activation after apoptosome formation, whereas prothymosin-alpha-1 negatively regulated caspase-9 activation by inhibiting apoptosome formation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: alpha-prothymosin; gene sequence 28; Prothymosin alpha; prothymosin alpha protein; prothymosin-alpha; thymosin; TMSB4; TMSB4X
基因别名: PTMA; Thym; TMSA
UniProt ID: (Human) P06454, (Mouse) P26350, (Rat) P06302
Entrez Gene ID: (Human) 5757, (Pig) 100294684, (Mouse) 19231, (Rat) 29222