Proteintech

PTP1B Polyclonal Antibody

40 篇参考文献
查看其他31个PTP1B抗体

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}

说明书
实验方案
问题与答案
技术支持
说明书
实验方案
问题与答案
技术支持
说明书
实验方案
问题与答案
技术支持
PTP1B Polyclonal Antibody

产品信息

11334-1-AP

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:2,000-1:10,000
查看25篇已发表文章 25篇已发表文章

免疫组化 (IHC)

-
查看7篇已发表文章 7篇已发表文章

免疫组化（石蜡） (IHC (P))

1:20-1:200
-

免疫细胞化学 (ICC/IF)

1:10-1:100
查看4篇已发表文章 4篇已发表文章

免疫沉淀 (IP)

0.5-4.0 µg
查看4篇已发表文章 4篇已发表文章
产品规格

种属反应

Human, Mouse, Rat

已发表种属

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

PTP1B Fusion Protein Ag1878 (1-435 aa encoded by BC015660)
查看免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.35 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice (domestic); Dry ice (international)

产品详细信息

Immunogen sequence: MEMEKEFEQ IDKSGSWAAI YQDIRHEASD FPCRVAKLPK NKNRNRYRDV SPFDHSRIKL HQEDNDYINA SLIKMEEAQR SYILTQGPLP NTCGHFWEMV WEQKSRGVVM LNRVMEKGSL KCAQYWPQKE EKEMIFEDTN LKLTLISEDI KSYYTVRQLE LENLTTQETR EILHFHYTTW PDFGVPESPA SFLNFLFKVR ESGSLSPEHG PVVVHCSAGI GRSGTFCLAD TCLLLMDKRK DPSSVDIKKV LLEMRKFRMG LIQTADQLRF SYLAVIEGAK FIMGDSSVQD QWKELSHEDL EPPPEHIPPP PRPPKRILEP HNGKCREFFP NHQWVKEETQ EDKDCPIKEE KGSPLNAAPY GIESMSQDTE VRSRVVGGSL RGAQAASPAK GEPSLPEKDE DHALSYWKPF LVNMCVATVL TAGAYLCYRF LFNSNT (1-435 aa encoded by B C015660)

靶标信息

PTP1B (PTPN1) is a tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. It mediates dephosphorylation of EIF2AK3/PERK and in turn inactivates the protein kinase activity of EIF2AK3/PERK. PTP1B also plays a role in CKII- and p60c-src-induced signal transduction cascades. It regulates the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. PTP1B also regulates the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

生物信息学

蛋白别名: CPTP1; EC 3.1.3.48; hgnc9642; KIAA0283; protein tyrosine phosphatase, placental; protein-protein-tyrosine phosphatase HA2; Protein-tyrosine phosphatase 1B; Protein-tyrosine phosphatase HA2; PTN1; PTP-1B; PTP-HA2; RP5-1121H13.2; RPTPrho; tyrosine phosphatase 1b; tyrosine-phosphatase; Tyrosine-protein phosphatase non-receptor type 1

查看更多 收起

基因别名: Ptp; PTP-1B; PTP-HA2; PTP1B; PTPN1

查看更多 收起

UniProt ID: (Human) P18031, (Rat) P20417, (Mouse) P35821

查看更多 收起

Entrez Gene ID: (Human) 5770, (Rat) 24697, (Mouse) 19246

查看更多 收起

功能
protein tyrosine phosphatase activity insulin receptor binding protein binding zinc ion binding enzyme binding protein kinase binding receptor tyrosine kinase binding poly(A) RNA binding ephrin receptor binding protein phosphatase 2A binding cadherin binding involved in cell-cell adhesion phosphoprotein phosphatase activity hydrolase activity phosphatase activity protein phosphatase
参与通路
protein dephosphorylation activation of signaling protein activity involved in unfolded protein response activation of JUN kinase activity insulin receptor signaling pathway regulation of signal transduction negative regulation of signal transduction regulation of endocytosis negative regulation of vascular endothelial growth factor receptor signaling pathway endoplasmic reticulum unfolded protein response actin cytoskeleton reorganization regulation of intracellular protein transport peptidyl-tyrosine dephosphorylation platelet-derived growth factor receptor-beta signaling pathway IRE1-mediated unfolded protein response negative regulation of MAP kinase activity negative regulation of insulin receptor signaling pathway regulation of type I interferon-mediated signaling pathway JAK-STAT cascade involved in growth hormone signaling pathway positive regulation of protein tyrosine kinase activity negative regulation of ERK1 and ERK2 cascade cell-cell adhesion regulation of hepatocyte growth factor receptor signaling pathway negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway positive regulation of IRE1-mediated unfolded protein response negative regulation of PERK-mediated unfolded protein response peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity positive regulation of receptor catabolic process regulation of insulin receptor signaling pathway dephosphorylation response to endoplasmic reticulum stress
guarantee_icon

性能保障

只要您发现Invitrogen抗体在实验中的表现与网站或说明书的所述内容不符，您即可享受免费退换货服务。*

了解更多
help_icon

随时为您服务

获取常见问题的专家解答，或者直接联系我们的技术专家，咨询应用、设备、常规产品使用问题。

联系技术支持