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Invitrogen
PTPRG Polyclonal Antibody
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PTPRG Antibody (PA5-19458) in WB
Western blot analysis of PTP RG using Product # PA5-19458, PTP gamma primary antibody at a dilution of 1 µg/mL (lane 1). Staining of PTP RG at a dilution of 1 µg/mL (lane 2). Blot treated with a secondary HRP-conjugated Goat polyclonal anti-Rabbit antibody was used at a dilution of 1:3000.
产品信息
PA5-19458
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide derived from residues 1000 - 1100 of Human PTP gamma.
偶联物
形式
Liquid
浓度
0.2 mg/mL
保存条件
-20°C or -80°C if preferred
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
PA5-19458 targets PTP gamma in WB applications and shows reactivity with Human samples.
The PA5-19458 immunogen is synthetic peptide derived from residues 1000 - 1100 of Human PTP gamma.
PA5-19458 detects PTP gamma which has a predicted molecular weight of approximately 50-70 kDa.
靶标信息
RPTP gamma, also known as Receptor-type tyrosine-protein phosphatase gamma, R-PTP-gamma or PTPRG is a protein tyrosine phosphatase (PTP) is a candidate tumor suppressor gene since it is located on human chromosome 3p14.2-p21, a region frequently deleted in certain types of renal and lung carcinomas. In situ hybridization analysis reveals that RPTP gamma mRNA is expressed in specific regions of the brain and that the localization of RPTP gamma changes during brain development. RPTP gamma is composed of a putative extracellular domain, a single transmembrane domain, and a cytoplasmic portion with two tandem catalytic tyrosine phosphatase domains. The extracellular domain contains a stretch of 266 amino acids with striking homology to the zinc-containing enzyme carbonic anhydrase (CAH), indicating that RPTP gamma and RPTP beta (HPTP zeta) represent a subfamily of receptor tyrosine phosphatases. RPTP gamma may have a function other than catalysis of hydration of metabolic CO2.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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