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Abnova
PTTG2 Polyclonal Antibody, MaxPab™
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产品信息
H00010744-D01P
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
PTTG2 (NP_006598.1, 1 a.a. approximately 191 a.a) full-length human protein.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MATLIYVDKE IGEPGTRVAA KDVLKLESRP SIKALDGISQ VLTPRFGKTY DAPSALPKAT RKALGTVNRA TEKSVKTNGP RKQKQPSFSA KKMTEKTVKT KSSVPASDDA YPEIEKFFPF NLLDFESFDL PEERQIAHLP LSGVPLMILD EEGELEKLFQ LGPPSPVKMP SPPWECNLFA VSFKHSVDPG C
靶标信息
The PTTG2 (Pituitary Tumor-Transforming Gene 2) gene is part of a family of securin proteins involved in regulating sister chromatid separation during cell division. Located on chromosome 8q13, PTTG2 acts as a securin, inhibiting separase to prevent premature separation of sister chromatids until proper chromosome alignment is achieved during mitosis. PTTG2 is expressed in various tissues and has been implicated in tumorigenesis due to its role in cell cycle regulation and its potential to induce genetic instability when dysregulated. Overexpression of PTTG2 has been observed in several cancers, including pituitary adenomas, and is associated with increased cell proliferation, invasion, and metastasis. Due to its involvement in mitotic regulation and tumor development, PTTG2 is considered a potential biomarker for cancer diagnosis and prognosis, as well as a target for therapeutic intervention. Understanding the molecular mechanisms regulated by PTTG2 could aid in the development of novel cancer treatments.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Pituitary tumor-transforming gene 2 protein; Securin-2
基因别名: PTTG2
UniProt ID: (Human) Q9NZH5
Entrez Gene ID: (Human) 10744
