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Invitrogen
PTTG2 Polyclonal Antibody
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PTTG2 Antibody (PA5-30881) in ICC/IF
PTTG2 Polyclonal Antibody detects PTTG2 protein at nucleus by immunofluorescent analysis. Sample: NT2D1 cells were fixed in 4% paraformaldehyde at RT for 15 min. Green: PTTG2 protein stained by PTTG2 Polyclonal Antibody (Product # PA5-30881) diluted at 1:1,000. Blue: Hoechst 33342 staining.
产品信息
PA5-30881
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein encompassing a sequence within the center region of human PTTG2. The exact sequence is proprietary.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7, with 1% BSA, 20% glycerol
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Recommended positive controls: NT2D1, IMR32, U87-MG.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
The PTTG2 (Pituitary Tumor-Transforming Gene 2) gene is part of a family of securin proteins involved in regulating sister chromatid separation during cell division. Located on chromosome 8q13, PTTG2 acts as a securin, inhibiting separase to prevent premature separation of sister chromatids until proper chromosome alignment is achieved during mitosis. PTTG2 is expressed in various tissues and has been implicated in tumorigenesis due to its role in cell cycle regulation and its potential to induce genetic instability when dysregulated. Overexpression of PTTG2 has been observed in several cancers, including pituitary adenomas, and is associated with increased cell proliferation, invasion, and metastasis. Due to its involvement in mitotic regulation and tumor development, PTTG2 is considered a potential biomarker for cancer diagnosis and prognosis, as well as a target for therapeutic intervention. Understanding the molecular mechanisms regulated by PTTG2 could aid in the development of novel cancer treatments.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Pituitary tumor-transforming gene 2 protein; Securin-2
基因别名: PTTG2
UniProt ID: (Human) Q9NZH5
Entrez Gene ID: (Human) 10744
