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Abnova
PUF60 Monoclonal Antibody (1C1)
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产品信息
H00022827-M20
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1, kappa
分类
Monoclonal
类型
Antibody
克隆号
1C1
抗原
PUF60 (AAH11979, 1 a.a. approximately 516 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Western Blot (Transfected lysate).
Immunogen sequence: MENGQSTAAK LGLPPLTPEQ QEALQKAKKY AMEQSIKSVL VKQTIAHQQQ QLTNLQMAAV TMGFGDPLSP LQSMAAQRQR ALAIMCRVYV GSIYYELGED TIRQAFAPFG PIKSIDMSWD SVTMKHKGFA FVEYEVPEAA QLALEQMNSV MLGGRNIKVG RPSNIGQAQP IIDQLAEEAR AFNRIYVASV HQDLSDDDIK SVFEAFGKIK SCTLARDPTT GKHKGYGFIE YEKAQSSQDA VSSMNLFDLG GQYLRVGKAV TPPMPLLTPA TPGGLPPAAA VAAAAATAKI TAQEAVAGAA VLGTLGTPGL VSPALTLAQP LGTLPQAVMA AQAPGVITGV TPARPPIPVT IPSVGVVNPI LASPPTLGLL EPKKEKEEEE LFPESERPEM LSEQEHMSIS GSSARHMVMQ KLLRKQESTV MVLRNMVDPK DIDDDLEGEV TEECGKFGAV NRVIIYQEKQ GEEEDAEIIV KIFVEFSIAS ETHKAIQALN GRWFAGRKVV AEVYDQERFD NSDLSA
靶标信息
PUF60 encodes a protein that is a Ro RNP-binding protein. It interacts with Ro RNPs and their interaction is thought to represent a gain of function for Ro RNPs. This protein also forms a ternary complex with far upstream element (FUSE) and FUSE-binding protein. It can repress a c-myc reporter via the FUSE. It is also known to target transcription factor IIH and inhibit activated transcription. This gene is implicated in the xeroderma pigmentosum disorder. There are two alternatively spliced transcript variants of this gene encoding different isoforms. There seems to be evidence of multiple polyadenylation sites for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 60 kDa poly(U)-binding-splicing factor; FBP interacting repressor; FBP-interacting repressor; FLJ31379; FUSE-binding protein-interacting repressor; poly(U) binding splicing factor 60KDa; Poly(U)-binding-splicing factor PUF60; poly-U binding splicing factor 60KDa; pyrimidine tract binding splicing factor; Ro ribonucleoprotein-binding protein 1; Ro-binding protein 1; RoBP1; Siah binding protein 1; Siah-binding protein 1; Siah-BP1
基因别名: FIR; PUF60; ROBPI; SIAHBP1; VRJS
UniProt ID: (Human) Q9UHX1
Entrez Gene ID: (Human) 22827
